A5070731455- Insect Utilization and Effects
- Dermatology and Skin Diseases
- Hormonal and reproductive studies
- Urinary Bladder and Prostate Research
- Bee Products Chemical Analysis
- Protein Hydrolysis and Bioactive Peptides
- Phytochemicals and Antioxidant Activities
- Plant Toxicity and Pharmacological Properties
- Additive Manufacturing and 3D Printing Technologies
- Diet, Metabolism, and Disease
- Neurobiology and Insect Physiology Research
- Natural Antidiabetic Agents Studies
- Nanocomposite Films for Food Packaging
- Olfactory and Sensory Function Studies
- Food Industry and Aquatic Biology
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- biodegradable polymer synthesis and properties
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Meat and Animal Product Quality
- Allergic Rhinitis and Sensitization
- Antimicrobial agents and applications
- Phytochemicals and Medicinal Plants
- Bioactive Compounds in Plants
Hebei University of Science and Technology
2024-2025
Konkuk University
2018-2024
Konkuk University Medical Center
2023
Dong-A University
2023
Dongguan University of Technology
2020
This review summarizes the potential use of citrus peels in food industry. The present work is an overview different compounds extracted from various species peel and functional properties compounds, along with their applications as valuable ingredients food-based products. Citrus a natural source diverse bioactive including polyphenols, pectins, proteins, pigments, dietary fibers, essential oils. These exhibit many biological activities, antioxidant, antimicrobial, anticancer,...
Atopic dermatitis (AD) is a chronic inflammatory skin disease caused mainly by immune dysregulation. This study explored the anti-inflammatory and immunomodulatory effects of Centellaasiatica ethanol extract (CA) on an AD-like dermal disorder. Treatment with CA inhibited expression interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) in dose-dependent manner stimulated HaCaT cells interferon-γ (IFN-γ) TNF-α-triggered inflammation. Eight-week-old BALB/c mice treated 2,4-dinitrochlorobenzene...
Tiger nuts were enzymatically hydrolyzed by Alcalase and then separated purified ultrafiltration classification Sephadex G-15 fractionation to obtain tiger nut peptides. Their chemical antioxidant activities cytoprotective functions on HepG2 Caco-2 cells systematically evaluated in this study. The peptides (TNP) found perform excellent activity supported their cell behaviors, amino acid composition, morphological observation. Higher 1,1-diphenyl-2-picrylhydrazyl radical scavenging (DPPH•...
We investigated the therapeutic potential of polymerized anthocyanin (PA) on a nonalcoholic fatty liver disease (NAFLD) model in mice. C57BL/6 mice were fed high-fat diet (HFD) for 8 weeks to establish NAFLD mouse and randomly divided into four groups: control (con), treated with saline (NAFLD), PA (PA), orlistat (Orlistat) weeks. Mice euthanized at end Total cholesterol (TC) triglyceride (TG) levels estimated, pathological changes liver, white adipose tissue, signaling pathways related...
The study determined the effect of incorporating Momordica charantia leaf powder (MCLP) into corn-starch 3D food-printing ink as a functional ingredient. effects particle size (75, 131, and 200 μm) quantity MCLP on printing performance, structural, textural, rheological properties corn starch gel were evaluated with different concentrations (5, 10, 15 % (w/w)) starch. viscoelastic food inks considering their behavior during extrusion self-recovery after printing. Scanning electron microscope...
Benign prostatic hyperplasia (BPH) is a common chronic disease of the urinary system among elderly men. Especially, metabolic imbalance androgen in men one leading causes BPH. Dihydrotestosterone (DHT) and converted testosterone by 5-α reductase type 2 (5AR2), binding with receptor (AR), affect prostate proliferation growth. In BPH, levels signaling-related protein expression are shown highly. Androgen signaling induces overexpression prostate-specific antigen (PSA) cell factor such as...
To explore the inhibitory mechanism of heat-killed
The present study determines whether antler extract (AE) possesses inhibitory effects in a prostate cancer (PC) xenograft model and explores the underlying mechanism. After therapeutic intervention for two weeks, AE significantly inhibited tumor growth by 65.08%, prostate-specific antigen (PSA) serum dihydrotestosterone (DHT) levels. However, increased testosterone level compared to vehicle control group. Furthermore, our investigation of on angiogenesis epithelial-to-mesenchymal transition...
Dry eye disease is a chronic, progressive ocular characterised by discomfort and one of the most common ophthalmological disorders that affects people's lives.This study investigated clinical efficacy anthocyanin oligomers (grape skin extract) for treatment dry eye. One hundred eight patients with were randomly divided into placebo groups, each 54 cases. The group received maltodextrin (800 mg/day) mg/day). Clinical efficacy, indices, occurrence adverse reactions compared between two...
: Benign prostatic hyperplasia (BPH) is one of the major public health concerns, which has a high prevalence rate and causes significant decline in men's quality life. BPH highly related to sexual hormone metabolism aging. In particular, dihydrotestosterone (DHT), testosterone modified by 5α-reductase (5AR), effect on development. DHT binds an androgen receptor (AR) steroid coactivator 1 (SRC-1); then, it induces proliferation prostate cell expression specific antigen (PSA). Paecilomyces...
This study investigated the effects of Momordica charantia (M. charantia) extract in obesity and abnormal lipid metabolism mice fed high fat diet (HFD). Fruit, root, stem, leaf extracts M. were obtained using distilled water, 70% ethanol 95% hexane. water (MCLW) showed highest antioxidant activity both 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging tests reducing power. Metabolite profiles analyzed for identification bioactive compounds. HFD-fed treated with MCLW (oral dose 200...
Abstract Considering the emergence of bacterial resistance and low proteolytic stability antimicrobial peptides (AMPs), herein we developed a series ultra-short triazine based amphipathic polymers (TZP) that are connected with ethylene diamine linkers instead protease sensitive amide bond. The most potent oligomers, TZP3 TZP5 not only displayed antibacterial action on various drug-resistant pathogens but also exhibited strong synergic activity in combination chloramphenicol against...
In this study, we investigated the anti-obesity properties of novel peptide Ala-Gly-Leu-Gln-Phe-Pro-Val-Gly-Arg (AGL9), isolated from enzymatic hydrolysate Allomyrinadichotoma larvae. To investigate preventive effects AGL9 against hepatic steatosis and its possible mechanisms action, established an nonalcoholic fatty liver disease (NAFLD) model by feeding C57BL/6 mice a high-fat diet. NAFLD were administered 100 mg/kg 60 orlistat via gavage (10 mL/kg) for 5 weeks, followed collection blood...
The aim of this study was to identify an anti-obesity peptide from Allomyrina dichotoma and investigate the lipid metabolic mechanism. Enzymatically hydrolyzed A. larvae were further separated using tangential flow filtration consecutive chromatographic processes. Finally, that showed highest inhibitory effect on accumulation obtained, sequence Glu-Ile-Ala-Gln-Asp-Phe-Lys-Thr-Asp-Leu (EIA10). EIA10 decreased aggregation in vitro significantly reduced body weight gain, liver weight, adipose...
Atopic dermatitis (AD) is a widely researched chronic inflammatory skin disease with complex etiology. The increased prevalence of AD necessitates exploration natural sources as potential therapeutic agents limited side effects. In the current study, 1-chloro-2,4-dinitrobenzene (DNCB)-induced mouse model was used to examine anti-AD effects Tenebrio molitor trypsin hydrolysate (TMTH) and its underlying molecular mechanism. DNCB-treated mice were treated TMTH (1 10 mg/kg), prednisolone (3...
We evaluated the effect of isoquercetin (quercetin-O-3-glucoside-quercetin, IQ) as a functional component <em>Abeliophyllum disistichum</em> Nakai ethanol extract (ADLE) on prostate cell proliferation and apoptosis its effects IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia (BPH). Metabolites ADLE were analyzed using UHPLC-qTOF-MS HPLC. IQ was orally administered (1 or 10 mg/kg) to testosterone propionate-induced BPH rat model, weight evaluated. The androgen receptor (AR)...
This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and mechanisms underlying these effects. To this end, actions two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) N-trans-coumaroyltyramine (NCPA), were determined AD by orally administering them mice. Oral administration ameliorated increase in epidermal dermal thickness as well mast cell infiltration. Cinnamamides suppressed serum immunoglobulin (Ig) levels expression T-helper (Th)1/Th2...
Centella asiatica (L.) Urban (C. asiatica) is a traditional herbal medicine that has been used for wound healing and anti-inflammation since ancient times. Various biological effects of C. ethanolic extract (CAE) were previously reported. However, in our previous study, aqueous (CAA) exhibited higher inhibitory activity on benign prostatic hyperplasia (BPH) than CAE. Therefore, the aim this study was to investigate effect CAA BPH, elucidate mechanism through vitro vivo experiments as well...
Atopic dermatitis (AD) is a long-lasting inflammatory skin disease that contributes to the global health burden and impacts 10–20% of world’s population. In this study, we determined anti-AD effect by-product silkworm (Bombyx mori) larval powder, strain Yeonnokjam (SLPY), as sustainable, natural source for development therapeutic agents AD. HaCaT cells were used assess in vitro anti-inflammatory activity SLPY, 1-chloro-2,4-dinitrobenzene (DNCB)-induced mouse model was study vivo effects....
We investigated the metabolite changes of Morus roots (MRs) according to different cultivar families (Simheung, Daesim, Cheong-il, Sangchon, Daeseong, Suhong, Suwon, and Igsu) using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) understand relationship between cultivars changes. Data were analyzed by partial least squares discriminant analysis (PLS-DA), samples successfully separated in PLS-DA scores. Eight metabolites electrospray...