A5007011488- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Dermatological and Skeletal Disorders
- Nail Diseases and Treatments
- Glutathione Transferases and Polymorphisms
- Drug-Induced Adverse Reactions
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Contact Dermatitis and Allergies
- Plant Reproductive Biology
- Skin Protection and Aging
- melanin and skin pigmentation
- Nonmelanoma Skin Cancer Studies
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Wound Healing and Treatments
- Parvovirus B19 Infection Studies
- Dermatologic Treatments and Research
- Eosinophilic Disorders and Syndromes
- Hair Growth and Disorders
- Systemic Lupus Erythematosus Research
- Genomics, phytochemicals, and oxidative stress
- Laser Applications in Dentistry and Medicine
- Autoimmune and Inflammatory Disorders
- Silk-based biomaterials and applications
University Hospitals Birmingham NHS Foundation Trust
2021-2025
University of Birmingham
2020-2025
NIHR Surgical Reconstruction and Microbiology Research Centre
2024
Solihull Hospital
2001-2023
National Health Service
2023
Heart of England NHS Foundation Trust
2008-2020
Queen Elizabeth Hospital Birmingham
2020
University of Warwick
2017
University of London
2015
Universidad de Londres
2015
LH 7:2 is a monoclonal antibody that was raised against an extract of human epidermal cells and identifies epitope within the lamina densa basement membrane stratified squamous epithelia. Using indirect immunofluorescence we found intense labelling with at (EBM) normal skin, in skin samples from patients simplex, junctional, dominantly inherited dystrophic acquired forms epidermolysis bullosa (EB), as well bullous pemphigoid. Staining absent or only very faint generalized recessive EB...
Basal cell carcinoma (BCC) is the commonest malignant neoplasm in white people. We present a large UK case-control study which conditional logistic regression analysis of age-matched and gender-matched data sets was used to compare, first, cases with controls (n=403) second, patients having multiple BCC those single (n=278). Eye/hair colour, occupation, skin type, social class, tumour site at presentation smoking history were assessed. Social class 1/2, type 1, red/blonde hair blue/green...
The genetic factors that mediate the pathogenesis of multiple primary cutaneous basal cell carcinomas (BCC) are largely unclear. Thus, some patients suffer many BCC (>30) and/or rapid accrual (number tumours/year from first presentation) further lesions. We have studied, in 827 English Caucasians, influence polymorphism carcinogen-metabolizing enzymes on susceptibility to this cancer. Accordingly, we describe, first, a cross-sectional analysis GSTM1, GSTT1, CYP2D6 and CYP1A1 genotypes tumour...
AA3 is a novel antibody raised against human amnion, which reacts with the basement membrane of various epithelia ectodermal origin. We use to examine epidermal zone in normal skin and different genetically determined types epidermolysis bullosa (EB), by indirect immunofluorescence. staining was dystrophic simplex EB, but markedly reduced lesional non‐blistered severe forms junctional EB. In non‐lethal intensity variable appeared be inversely associated disease severity, did not correlate...
The National Health Service (NHS) epidermolysis bullosa (EB) service, established in 2002, offers comprehensive, free care to all patients England and Wales.To quantify prevalence, incidence mortality of EB Wales.Demographic data for Wales were collected on a secure electronic database, prospectively from January 2002 April 2021 retrospectively cases prior 2002. Vital status was verified using central NHS data.By March 2021, 2594 individuals registered, whom 2361 living, which yielded...
Journal Article Rapid prenatal diagnosis of epidermolysis bullosa letalis using GB3 monoclonal antibody Get access A.H.M. HEAGERTY, HEAGERTY Department Electron Microscopy and Cell Pathology, The Institute Dermatology, United Medical Dental Schools, St. Thomas' Hospital, London Search for other works by this author on: Oxford Academic Google Scholar R.A.J. EADY, EADY Dr Eady, Lambeth Palace Road, SE17EH, U.K. A.R. KENNEDY, KENNEDY K.H. NICOLALADES, NICOLALADES Harris Birthright Research...
<title>Abstract</title> Ablative fractional carbon dioxide (AFCO2) laser therapy is widely used for treating pathological scarring, with promising clinical results. However, mechanisms underlying reduction hypertrophic scarring are poorly understood. We investigated the cellular of AFCO2 by performing single-cell RNA sequencing (scRNA-seq) on skin biopsies from burn survivors scars before and after therapy. Those a good response (GR) to therapy, assessed objectively subjectively, generally...
Introduction The cutaneous microbiome plays an essential role in guarding against invasive pathogens and maintaining healthy skin homeostasis. Several studies have demonstrated the importance of a through its alteration several diseases. Differing characteristics across body (temperature, pH, humidity) create distinct ecological niches inhabited by diverse microbial communities. study microbiota is further complicated numerous variables at all stages investigation, including design, sampling...