Abstract Background Hidradenitis suppurativa (HS) is a chronic inflammatory disease that significantly affects the patient's quality of life. Multiple studies have shown strong association between HS and bowel (IBD). Our primary goal was to explore in‐hospital burden on patients with IBD. secondary establish unique baseline characteristics comorbidities IBD HS. Methods This retrospective cohort study using National Inpatient Sample (NIS) database for years 2004 through 2014. All ICD‐9 CM...

Abstract Obese children are at higher risk of developing psoriasis, and obesity severity is correlated with psoriasis severity. The relationship between pediatric was explored in a well‐defined population. Obesity coexist diagnosis, but it likely that commonly precedes children.

Junctional epidermolysis bullosa (JEB) is a rare autosomal recessive genodermatosis with broad spectrum of phenotypes. Current genotype-phenotype paradigms are insufficient to accurately predict JEB subtype and characteristics from genotype, particularly for splice site mutations, which account over fifth disease-causing mutations in JEB. This study evaluated genetic clinical findings cohort, investigating correlations through bioinformatic analyses comparison previously reported...

Objective/Background: Toxic erythema of chemotherapy (TEC) is a well-recognized adverse cutaneous reaction to chemotherapy. Similar many skin diseases, the clinical presentations may vary. Our objective expand on typical and atypical histopathological TEC. Methods: Forty patients with diagnosis TEC were included from 500 who had undergone an allogeneic hematopoietic stem cell transplant. Relevant information demonstrative photos pathology selected. Results: Classic hand foot dysesthesias;...

Abstract Background/Objectives Specific maternal risk factors have recently been identified in the development of infantile hemangiomas (IH), including gestational diabetes (GDM), antihypertensive medication use or hypertension (GHTN), progesterone use, and artificial reproductive technologies (ART). We sought to explore change incidence these over time determine their association with increased 35 years, as previously reported. Methods The charts 869 mother infant pairs (infants diagnosed...

The COVID-19 pandemic catapulted dermatology services into a digital era, with the rapid introduction of teleconsultations. UK National Health Service operational planning guidance recommends ≥ 25% consultations are delivered remotely. There is lack data regarding acceptability and effectiveness paediatric We surveyed healthcare professionals (HCPs) to explore their experiences teleconsultations in dermatology, focus on follow-up for eczema (PE), inform future clinical trial. were 119...

Abstract Background The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting capillary leak syndrome (CLS) is quite rare. Our objective was to identify type skin associated with CLS. Methods Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, medical records reviewed for a dermatology consultation occurring concomitantly Results Five two diagnosis toxic erythema chemotherapy (TEC) three others epidermal...

Narrowband ultraviolet B phototherapy (nbUVB) is a well-established, well-tolerated and efficacious treatment for eczema. There distinct lack of literature surrounding the therapeutic use nbUVB in eczema children especially with higher skin phototypes (III to VI).We undertook retrospective review aged 18 years under who had undergone our department between 1 January 2011 31 December 2017. Abstracted data included sex, age, phototype, severity as graded by paediatric dermatologist, cumulative...

Our study demonstrates that severity scores do not correlate well with the impact localized epidermolysis bullosa simplex (EBS) has on quality of life. There is a paucity literature exploring correlations between disease and patient-reported outcome measures in EB. Both Birmingham EB Severity (BEBS) score Disease Activity Index (EBDASI) consist weighted factors including body surface area, scalp, mucous membrane, nail systemic involvement, as complications longstanding such cutaneous...

Abstract We report a case of 21-year-old man who was referred from the community with concern about persistent swollen and inflamed eyelids together possible facial acne. He known to have hypertrophic osteoarthropathy under care rheumatology for which he on regular infliximab infusions. had previously been treated methotrexate (intolerant) azathioprine adalimumab (lack efficacy). also long-standing history inflammatory bowel disease associated complications: iron-deficiency anaemia, previous...

Abstract Paediatric dermatology teleconsultations have become familiar territory since the Covid-19 pandemic. There is a continued drive to provide teleconsultations, with efficiency and cost-saving cited as benefits. Yet, this not supported by recent UK-wide survey of health professionals.1 We evaluated practice across two paediatric centres, assess time required for teleconsultations. Data were collected prospectively from outpatient consultations patients <16 years over 2 weeks in...

Abstract Providing teleconsultations for appropriate patients is a priority outpatient service transformation, yet little evidence exists on their effectiveness and acceptability in paediatric eczema. We conducted UK-wide online patient parent survey to explore experiences of eczema teleconsultations. Further objectives included determining preferences costs incurred with different appointments. Young people (13-16 years) parents children (0-16 eczema, who had follow-up teleconsultation...

Abstract Sikh boys and girls, traditionally, keep their hair long tend to tie it up in a knot over the vertex of scalp; this is colloquially referred as ‘jura’. The repeated traction on coupled with weight often leads distinct loss pattern that can be concerning distressing for patients parents alike. We describe two cases alopecia young boys, who presented our tertiary paediatric service. first case 14-year-old boy reduced density follicles recession frontotemporal hairline. Similarly,...

Abstract The COVID-19 pandemic sparked a digital transformation within the National Health Service (NHS), changing how we deliver care and accelerating use of teleconsultations paediatric dermatology (McCusker S, King Stokes N, Hunjan M et al. Paediatric teleconsultations: survey healthcare professionals in UK. Clin Exp Dermatol 2023: 48: 785–9). Provision remains priority for outpatient service achieving NHS’s commitment to net zero carbon emissions by 2040. This qualitative interview study...

Abstract Surveys are a valuable research method in dermatology. They have multitude of applications, particularly understanding the impacts skin disease, treatments and services on patients. Increasingly researchers utilizing online surveys using social media to advertise. We describe our experience conducting an survey explore experiences parents adolescents having teleconsultations for eczema UK. The was distributed through Jisc platform advertised via platforms including Facebook,...

Epidermolysis bullosa (EB) is a devastating genetic condition caused by mutations in genes that give rise to aberrant proteins. There are 16 different such proteins implicated EB important maintaining the integrity of dermoepidermal junction. It classified into four major subtypes: (i) simplex; (ii) junctional (JEB); (iii) dystrophic (DEB); and (iv) Kindler EB. Renal disease recognized complication aetiology complex. We describe our experience managing five patients with IgA nephropathy....

Abstract Over one-fifth of disease-causing mutations in junctional epidermolysis bullosa (JEB) are splice site variants. These affect pre-mRNA splicing through the activation cryptic sites and/or exon skipping, resulting altered mRNA and translated proteins. Prediction precise location activated is vital, as these can potentially alter reading frame transcript. Out-of-frame transcripts contain premature termination complexes (PTCs), which generally result nonfunctional protein often...