A5040519506- Chemotherapy-induced organ toxicity mitigation
- Histone Deacetylase Inhibitors Research
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Reactions
- Phytochemistry and Biological Activities
- Genomics, phytochemicals, and oxidative stress
- Synthesis of Indole Derivatives
- Cancer Treatment and Pharmacology
- Sexual function and dysfunction studies
- Flavonoids in Medical Research
- Berberine and alkaloids research
- Pharmacological Effects and Toxicity Studies
Atatürk University
2017-2023
Abstract Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases. Naringin (4′,5,7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has wide range of biological and pharmacological activities, including antioxidant anti‐inflammatory potentials. This research aimed to investigate NRG activity OXL‐induced hepatorenal toxicity. Accordingly, OXL (4 mg/kg b.w.) 5% glucose was injected intraperitoneally on first, second, fifth, sixth days, (50 100 given orally 30 min...
The bismuth nitrate-promoted disproportionative condensation of indoles with cyclohexanone in one pot, to yield C3-cyclohexyl substituted and 1,3-di(1<italic>H</italic>-indol-3-yl)benzene derivatives is reported for the first time.
Valproic acid (VALP) is a drug used for many psychiatric diseases such as epilepsy. However, the use of VALP has potential side effects on various tissues, including testicles. Rutin (RUT) flavonoid with protective against oxidative stress-induced and lipid peroxidation. In this study, RUT testicular damage caused by were investigated. For purpose, 35 male Spraque-Dawley rats weighing 220-250 g in study. The randomly divided into 5 groups Control (physiological saline), (100 mg/kg/bw), VALP,...
Aim: Cancer is a disease that on the rise worldwide. Paclitaxel (PTX) one of most common chemotherapeutic agents used in treatment many cancers. PTX causes toxic effects by increasing oxidative stress tissues. Naringin powerful antioxidant found naturally plants, especially citrus fruits. The aim this study was to determine protective NRG PTX-induced sciatic nerve injury.
 Methods: Thirty-five male rats were randomly divided into five groups: control, PTX, NRG, PTX+NRG-50, PTX+NRG-100....
In this study, the protective effects of pentoxifylline (PTX), vitamin C and E on carboplatin toxicity were comparatively investigated in different organs tissues rats. Thirty adult rats divided into 5 groups (n=6), each comprising six animals treated daily for five days, by i.p. injections 0, 2 mL saline (Group I), 25 mg/kg II), + 150mg/kg III), 50 IV) V). At end treatment, blood samples collected direct cardiac puncture serum was used assay rnarker enzymes, alanine aminotransferase (ALT),...