A5028429546- Wound Healing and Treatments
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Diabetic Foot Ulcer Assessment and Management
- Bee Products Chemical Analysis
- Click Chemistry and Applications
- Plasma Applications and Diagnostics
- Immune cells in cancer
- Peptidase Inhibition and Analysis
- Periodontal Regeneration and Treatments
- Rabies epidemiology and control
- Histone Deacetylase Inhibitors Research
- Antimicrobial agents and applications
- Fungal Biology and Applications
- Molecular Biology Techniques and Applications
- Burn Injury Management and Outcomes
- Laser Applications in Dentistry and Medicine
- Thermoregulation and physiological responses
- Surgical Sutures and Adhesives
- Pressure Ulcer Prevention and Management
- Silk-based biomaterials and applications
Witten/Herdecke University
2017-2024
University Hospital Münster
2021-2023
Universität Hamburg
2020
University Medical Center Hamburg-Eppendorf
2020
Wound healing is a complex and dynamic process with different distinct overlapping phases from homeostasis, inflammation proliferation to remodelling. Monitoring the response of injured tissue high importance for basic research clinical practice. In traditional application, biological markers characterize normal abnormal wound healing. Understanding functional relationships these processes essential developing new treatment strategies. However, most present techniques (in vitro or in vivo)...
Despite of medical advances, the number patients suffering on non-healing chronic wounds is still increasing. This fact attended by physical and emotional distress an economic load. The majority are infected harmful microbials in a protecting extracellular matrix. These biofilms inhibit wound healing. Biofilm-growing bacteria developed unique survival properties, which challenge appropriate therapy. present in-vitro biofilm models not suitable for translational research. By means novel...
Biofilms pose a relevant factor for wound healing impairment in chronic wounds. With 78% of all wounds being affected by biofilms, research this area is high priority, especially since data evidence-based selection appropriate antimicrobials and antiseptics scarce. Therefore, the objective study was to evaluate anti-biofilm efficacy commercially available hypochlorous irrigation solutions compared established antimicrobials. Using an innovative complex in-vitro human plasma biofilm model...
Abstract The increasing incidence of non-healing wounds constitutes a pivotal socio-economic burden. 60–80% chronic are colonized by pathogenic microorganisms within protective extracellular polymeric substance, bearing great challenge in wound management. Human plasma was used to prepare the biofilm model (hpBIOM), adding pathogens and forming Coagula-like discs with integrated were produced. antiseptics Octenisept Lavasorb tested regarding their antibacterial properties on clinically...
The number of patients who has a daily intake antihypertensive drugs is rising, due to an also rising prevalence lifestyle diseases. Interestingly, knowledge about effects these in terms wound healing low.Based on few differing studies, the idea arose that antihypertensives may have side healing.Five from different substance classes (metoprolol, amlodipine, ramipril, hydrochlorothiazide, candesartan) were investigated, possible impacts cell metabolism and migration human skin fibroblasts...
Wound biofilms are one of the greatest challenges in therapy hard-to-heal (chronic) wounds, as potent antimicrobial substances fail to eradicate bacteria within short incubation periods. Preclinical investigations using novel model systems that closely mimic human wound environment and biofilm required identify new effective therapeutic options. This study aims bacterial colonisation patterns relevant for diagnosis therapy.In this study, a recently established plasma (hpBIOM) was...
The treatment of chronic wounds still represents a major challenge in wound management. Recent estimates suggest that 60–80% are colonized by pathogenic microorganisms, which strongly considered to have inhibiting influence on the healing process. By means an innovative biofilm model based human plasma, time-dependent behavior various bacterial strains under wound-milieu-like conditions were investigated, and growth habits different cocci species compared. Undescribed fusion events between...
If a wound progressively heals or the healing process is impaired basically influenced by surrounding milieu. This reflected fluid. Its specific composition triggers migration, proliferation and differentiation of dermal epidermal cells which so far was not sufficiently examined in 2D cell culture models. The influence different entities analyzed on newly implemented three dimensional in-vitro model, improved transferability to in-vivo situation. pooled fluids from patients suffering acute...
There is compelling evidence suggesting a pivotal role played by macrophages in orchestrating intestinal wound healing. Since display significant plasticity and heterogeneity, exhibiting an either classically activated (M1-like) or alternatively (M2-like) phenotype, they can aggravate attenuate Growing also demonstrates causal link between impaired mucosal healing inflammatory bowel disease (IBD) defects the polarization of pro-resolving macrophages. By targeting switch from M1 to M2...
Farnesyltransferase inhibitors (FTIs) are focus for the treatment of several diseases, particularly in field cancer therapy. Their potential, however, goes even further, as a number studies have evaluated FTIs infectious diseases such malaria, African sleeping sickness, leishmaniosis, and hepatitis D virus infection. Little is known about protein prenylation mechanisms human pathogens. However, disruption IspA, gene encoding geranyltranstransferase Staphylococcus aureus (S. aureus) leads to...
<title>Abstract</title> Background Biofilms pose a relevant factor for wound healing impairment in chronic wounds. With 78% of all wounds being affected by biofilms, research this area is high priority, especially since data evidence-based selection appropriate antimicrobials and antiseptics scarce. Therefore, the objective study was to evaluate anti-biofilm efficacy commercially available hypochlorous irrigation solutions compared established antiseptics. Methods Using an innovative complex...