A5028445962- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Multimodal Machine Learning Applications
- Cell Adhesion Molecules Research
- Heterotopic Ossification and Related Conditions
- NF-κB Signaling Pathways
- interferon and immune responses
- Inflammatory mediators and NSAID effects
- Angiogenesis and VEGF in Cancer
- Salivary Gland Disorders and Functions
- Pain Mechanisms and Treatments
- Domain Adaptation and Few-Shot Learning
- Kruppel-like factors research
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic Syndromes and Imprinting
- Bone and Dental Protein Studies
- Growth Hormone and Insulin-like Growth Factors
- Fibroblast Growth Factor Research
- Mesenchymal stem cell research
Osaka University
2015-2024
ORCID
2021
Princeton University
2019-2020
Stanford University
2016-2017
Okayama University
2012
Matsumoto Dental University
2012
The University of Texas Health Science Center at San Antonio
2012
Maine Medical Center Research Institute
2012
Tokyo Metropolitan University
2012
Doshisha Women's College of Liberal Arts
2011
Despite progress in perceptual tasks such as image classification, computers still perform poorly on cognitive description and question answering. Cognition is core to that involve not just recognizing, but reasoning about our visual world. However, models used tackle the rich content images for are being trained using same datasets designed tasks. To achieve success at tasks, need understand interactions relationships between objects an image. When asked "What vehicle person riding?", will...
Most natural videos contain numerous events. For example, in a video of "man playing piano", the might also "another man dancing" or "a crowd clapping". We introduce task dense-captioning events, which involves both detecting and describing events video. propose new model that is able to identify all single pass while simultaneously detected with language. Our introduces variant an existing proposal module designed capture short as well long span minutes. To dependencies between video, our...
Osterix/Sp7, a member of the Sp1 transcription factor family, plays an essential role in bone formation and osteoblastogenesis. Although Osterix has been shown to be induced by BMP2 mesenchymal cell line, molecular basis regulation, expression function during osteoblast differentiation, is not fully understood. Thus we examined signaling regulation using lines C3H10T1/2 C2C12. overexpression alkaline phosphatase activity osteocalcin C2C12 cells stimulated calcification murine primary...
Receptor activator of NF-kappaB ligand (RANKL) plays an essential role in osteoclast formation and bone resorption. Although genetic biochemical studies indicate that RANKL regulates differentiation by activating receptor associated signaling molecules, the molecular mechanisms RANKL-regulated have not yet been fully established. We investigated transcription factor c-Jun, which is activated RANKL, osteoclastogenesis using transgenic mice expressing dominant-negative c-Jun specifically...
Receptor activator of NF-κB ligand (RANKL) plays an essential role in osteoclast formation and bone resorption. Although genetic biochemical studies indicate that RANKL regulates differentiation by activating receptor associated signaling molecules, the molecular mechanisms RANKL-regulated have not yet been fully established. We investigated transcription factor c-Jun, which is activated RANKL, osteoclastogenesis using transgenic mice expressing dominant-negative c-Jun specifically lineage....
Despite progress in perceptual tasks such as image classification, computers still perform poorly on cognitive description and question answering. Cognition is core to that involve not just recognizing, but reasoning about our visual world. However, models used tackle the rich content images for are being trained using same datasets designed tasks. To achieve success at tasks, need understand interactions relationships between objects an image. When asked "What vehicle person riding?", will...
Computer vision models learn to perform a task by capturing relevant statistics from training data. It has been shown that spurious age, gender, and race correlations when trained for seemingly unrelated tasks like activity recognition or image captioning. Various mitigation techniques have presented prevent utilizing learning such biases. However, there little systematic comparison between these techniques. We design simple but surprisingly effective visual benchmark studying bias...
The microtubule-associated protein Tau is a major component of the neurofibrillary tangles that serve as neuropathological hallmark Alzheimer's disease. substrate for phosphorylation at multiple sites and occurs in hyperphosphorylated state. However, physiological functions or how it may contribute mechanistically to pathophysiology are not completely understood. Here, we examined function human three sites, Ser199, Ser202, Thr205, which together comprise AT8 mark abnormal Overexpression...
Bone morphogenetic protein 2 (BMP2) promotes the differentiation of undifferentiated mesenchymal cells into adipocytes. To investigate molecular mechanisms that regulate this process, we studied relationship between BMP2 signaling and peroxisome proliferator-activating receptor γ (PPARγ) during adipogenesis by using pluripotent cell line C3H10T1/2. In C3H10T1/2 cells, induced expression PPARγ along with adipogenesis. Overexpression Smad6, a natural antagonist for Smad1, blocked adipocytic...
Mice deficient in the Msx2 gene manifest defects skull ossification and a marked reduction bone formation associated with decreases osteoblast numbers, thus suggesting that is involved formation. However, precise role of during differentiation not fully understood. In present study, we investigated regulation multipotent mesenchymal cell lines C3H10T1/2 C2C12 murine primary osteoblasts. Introduction induced alkaline phosphatase activity cells promoted calcification This effect was also...
Genetic and cell biological studies have indicated that Indian hedgehog (Ihh) plays an important role in bone development osteoblast differentiation. However, the molecular mechanism by which Ihh regulates differentiation is complex remains to be fully elucidated. In this study, we investigated of signaling using mesenchymal cells primary osteoblasts. We observed stimulated alkaline phosphatase (ALP) activity, osteocalcin expression, calcification. Overexpression Gli2- but not Gli3-induced...
The ventromedial hypothalamus (VMH) is a distinct morphological nucleus involved in feeding, fear, thermoregulation, and sexual activity. It essentially unknown how VMH circuits underlying these innate responses develop, part because the remains poorly defined at cellular molecular level. Specifically, there paucity of cell-type-specific genetic markers with which to identify neuronal subgroups manipulate development signaling vivo . Using gene profiling, we now ∼200 genes highly enriched...
Accumulating evidence indicates that the acidic microenvironments critically influence malignant behaviors of cancer including invasiveness, metastasis, and chemoresistance. Because vacuolar-type H(+)-ATPase (V-ATPase) has been shown to cause extracellular acidification by pumping protons, we studied role V-ATPase in distant metastasis. Real-time PCR analysis revealed high-metastatic B16-F10 melanoma cells strongly expressed a3 isoform compared low-metastatic B16 parental cells. Consistent...
Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating process organogenesis. These processes strictly regulated morphogen signalling and transcriptional networks. However, precise transcription factors involved organogenesis exocrine glands, including salivary remain unknown. Here, we identify a specific combination two (Sox9 Foxc1) responsible for differentiation mouse embryonic cell-derived oral ectoderm into...
Metabolic reprogramming is a malignant phenotype of cancer. Cancer cells utilize glycolysis to fuel rapid proliferation even in the presence oxygen, and elevated coupled lactate fermentation cancer microenvironment. Although has been recognized as metabolic waste product, it become evident that functions not only an energy source but signaling molecule through receptor G-protein-coupled 81 (GPR81) under physiological conditions. However, pathological role GPR81 remains unclear. Here, we show...
RANKL is known to be important not only for differentiation and activation of osteoclasts but also their survival. Experimentally, apoptosis rapidly induced by the deprivation RANKL. activates Elk-related tyrosine kinase (ERK), p38, c-Jun N-terminal (JNK), NF-kappaB pathways through TRAF6 in precursor cells. It has been shown that ERK critical regulation osteoclast However, an involvement other signaling such as JNK survival fully understood yet.Osteoclasts derived from primary mouse bone...
Increased production of calcitonin gene-related peptide (CGRP) in sensory neurons is implicated inflammatory pain. The site acidic due to proton release from infiltrating cells. Acid activation peripheral nociceptors relays pain signals the CNS. Here, we examined whether acid activated transient receptor potential vanilloid subtype 1 (Trpv1), a widely recognized acid-sensing nociceptor and subsequently increased CGRP expression. Chemically induced inflammation was associated with thermal...
Abstract The continuous release of bone-stored growth factors after bone resorption promotes the colonization circulating cancer cells. However, precise role each various remains unclear. In this study, we investigated bone-derived insulin-like factor (IGF) in development metastases an animal model breast cancer. We found that local stimulation calvarial before cell inoculation stimulated subsequent to site vivo, although inhibition inhibited metastases. Anchorage-independent cells was by...