A5025228053- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Breast Cancer Treatment Studies
- Endoplasmic Reticulum Stress and Disease
- Gene expression and cancer classification
- Hematopoietic Stem Cell Transplantation
- Muscle Physiology and Disorders
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Nanoplatforms for cancer theranostics
- Galectins and Cancer Biology
- Cardiac Valve Diseases and Treatments
- Signaling Pathways in Disease
- Pharmacology and Obesity Treatment
- Cytomegalovirus and herpesvirus research
- Chemokine receptors and signaling
- Growth Hormone and Insulin-like Growth Factors
- Elasticity and Material Modeling
- Glycosylation and Glycoproteins Research
- Lipid metabolism and disorders
- Immune cells in cancer
- Metastasis and carcinoma case studies
- Oral health in cancer treatment
Yamaguchi University
2021-2024
Massachusetts Institute of Technology
2018-2021
Tokyo Medical University
2018
The University of Tokyo
2015
Japan Society for the Promotion of Science
2015
National Cancer Research Institute
2013
Osaka University
1986-2012
Kyorin University
1997
Osaka International Cancer Institute
1991-1993
Saba University School of Medicine
1986
Breast cancer patients often develop metastatic disease years after resection of the primary tumor. The are asymptomatic because disseminated cells appear to become dormant and undetectable. Because proliferation these is slowed, unresponsive traditional chemotherapies that exploit rapid cell cycling most cells. We generated a bone marrow-metastatic human breast line (BM2) by tracking isolating fluorescent-labeled MDA-MB-231 marrow in mice. Coculturing BM2 with mesenchymal stem (BM-MSCs)...
Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain the migration cells through blood-brain barrier (BBB). However, molecular mechanism behind passage this natural remains unclear. Here we show that cancer-derived extracellular vesicles (EVs), mediators cell-cell communication via delivery proteins and microRNAs (miRNAs), trigger breakdown BBB. Importantly, miR-181c promotes destruction BBB abnormal localization actin downregulation its...
Metastasis is the main cause of cancer mortality for many types cancer; however, difficulties remain in effectively preventing metastasis. It has been recently and widely reported that cancer-derived extracellular vesicles (EVs) contribute to Thus, therapeutic strategies targeting EVs hold great promise because possibility driving microenvironment toward Here, we provide a novel strategy antibody treatment target inhibit metastasis breast mouse model, establishing rationale further clinical...
The tetraspanin CD63 is a highly N-glycosylated protein that known to regulate cancer malignancy. However, the contribution of glycosylation malignancy remains unclear. Previously, we reported ribophorin II (RPN2), which part an N-oligosaccharyle transferase complex, responsible for drug resistance in breast cells. In this study, demonstrate associated with regulated by RPN2. Inhibition RPN2 expression led reduction glycosylation. addition, localization was deregulated knockdown...
ABSTRACT Extracellular vesicles (EVs) from cancer are delivered both proximal and distal organs. EVs highly glycosylated at the surface where interact with cells therefore has an impact on their properties biological functions. Aberrant glycosylation in is associated progression metastasis. However, function of EV uncovered. We first demonstrated differential profiles originated cells, distinct a brain‐metastatic subline BMD2a its parental human breast cell line, MDA‐MB‐231‐luc‐D3H2LN by...
BACKGROUND. Sequential administration of paclitaxel plus combined fluorouracil, epirubicin, and cyclophosphamide (P-FEC) is 1 the most common neoadjuvant chemotherapies for patients with primary breast cancer produces pathologic complete response (pCR) rates 20% to 30%. However, a predictor pCR this chemotherapy has yet be developed. The authors developed such by using proprietary DNA microarray gene expression analysis tumor tissues. METHODS. Tumor samples were obtained from 84 core-needle...
Abstract BACKGROUND: The aim of the present study was to investigate prognostic value genomic grade index for lymph node‐negative and estrogen receptor (ER)‐positive breast cancers Japanese women treated with adjuvant hormonal therapy alone, as well relation between pathological complete response (CR) neoadjuvant chemotherapy. METHODS: Genomic determined by DNA microarray (U133plus2.0; Affymetrix, Santa Clara, Calif) in tumor tissues obtained from ER‐positive (n = 105) alone or biopsy...
Dysferlinopathies are muscular dystrophies caused by recessive loss-of-function mutations in dysferlin (
The prophylactic effect of acyclovir (ACV) on varicella-zoster virus (VZV) infection in leukaemia patients who have undergone bone marrow transplantation (BMT) was reviewed. benefits the use laminar air flow (LAF) room prevention nosocomial VZV infections haematological ward are also discussed. Since 1986 ACV has been administered to BMT prevent herpes simplex (HSV) infections. Of 98 with underwent BMT, 73 received (200 mg five times daily) and 25 were not given ACV. In untreated group, 9...
Abstract The clinical diagnosis of major depressive disorder (MDD), a heterogeneous disorder, still depends on subjective information in terms various symptoms regarding mood. Detecting extracellular vesicles (EVs) blood may result finding diagnostic biomarker that reflects the stage patients with MDD. Here, we report results glycosylation pattern enriched plasma EVs from MDD and age-matched healthy subjects. In this cohort, levels Triticum vulgaris (wheat germ) agglutinin (WGA), N -acetyl...
The clinical diagnosis of major depressive disorder (MDD) still depends on subjective information in terms various symptoms regarding mood. Detecting the characterization extracellular vesicles (EVs) blood may result finding a diagnostic biomarker that reflects stage patients with MDD. Here, we report results glycosylation pattern enriched plasma EVs from We compared patterns by lectin blotting expressed isolated both MDD and age-matched healthy control participants (HCs) using...
Sodium selenate (selenate), as well insulin, increased the lipoprotein lipase (LPL) activity in isolated rat fat pads a time- and dose-dependent manner. The increase effect of was not additive to that insulin. action insulin decreased by amiloride disappeared when Ca2+ omitted from incubation medium. Loading chelator intracellular also greatly inhibited selenate. maximal inositol 1,4,5-trisphosphate (IP3) content observed with 30-s Dibutyryl cyclic AMP, 3-isobutyl-1-methylxanthine, carbonyl...
The purpose of this study was to analyze the role homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 (Herpud1) gene in development cardiomyocyte hypertrophy. In order examine effect suppressing Herpud1 expression, small interfering RNA (siRNA) introduced into H9C2 cells, which are cell lines derived from rat myocardium, and degree protein expression hypertrophy siRNA-transfected group control compared by immunostaining 48 h after Herrpud1 siRNA...