A5048592741- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Insect behavior and control techniques
- Neurobiology and Insect Physiology Research
- CRISPR and Genetic Engineering
- Gastroesophageal reflux and treatments
- Viral gastroenteritis research and epidemiology
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Animal Genetics and Reproduction
- Congenital heart defects research
- Monoclonal and Polyclonal Antibodies Research
- Advanced MRI Techniques and Applications
- Dysphagia Assessment and Management
- Hemispheric Asymmetry in Neuroscience
- Pharmacological Effects of Natural Compounds
- Congenital Heart Disease Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Coronary Artery Anomalies
Vanderbilt University Medical Center
2020-2025
Vanderbilt University
2020
University of Dayton
2017-2018
Cross-sectional studies suggest that hippocampal volume declines across stages of psychosis. In contrast, longitudinal indicate is stable in the critical period following illness onset. How can these seemingly disparate sets findings be resolved? present study, we examine two previously unexplored reasons for this discrepancy. First, only specific subregions hippocampus may change during early stage Second, there diagnostic heterogeneity psychosis and cross-sectional analysis does not permit...
Hippocampal volume is smaller in schizophrenia, but it unclear when the illness changes appear and whether specific regions (anterior, posterior) subfields (CA1, CA2/3, dentate gyrus, subiculum) are affected. Here, we used a high-resolution T2-weighted sequence specialized for imaging hippocampal to test hypothesis that anterior CA1 lower early psychosis. We measured subfield volumes across group of 90 individuals stage non-affective psychotic disorder 70 demographically similar healthy...
Gene expression evolution through gene regulatory network (GRN) changes has gained appreciation as a driver of morphological evolution. However, understanding how GRNs evolve is hampered by finding relevant cis-regulatory element (CRE) mutations, and interpreting the protein-DNA interactions they alter. We investigated evolutionary in duplicated Bric-à-brac (Bab) transcription factors key Bab target GRN underlying novel dimorphic pigmentation D. melanogaster its relatives. It remained...
The massa intermedia (MI) is a midline structure connecting the left and right thalamus that typically develops during 2 nd trimester of pregnancy. Missing smaller MI has been linked to neurodevelopmental disorders, including schizophrenia (SZ), subtle deficits in cognition. However, findings are inconsistent association between other anatomical variants atypical brain development SZ, incomplete hippocampal inversion (IHI), unclear. Presence/absence morphology were ascertained on structural...
The hippocampus is smaller and functionally disrupted in individuals with 22q11.2 deletion syndrome (22q11DS), though the cause remains unclear. During gestational weeks 20-30 an inversion dentate gyrus cornu ammonis occurs. This process can go awry resulting incomplete hippocampal (IHI). In general population, IHI more common left hemisphere than right; yet its prevalence, severity, functional impact 22q11DS remain unexplored. Investigating could uncover morphological abnormalities linked...
Highlights•Developed a task to interrogate allocating attention with conflicting inputs•People schizophrenia are more susceptible inputs•Right MD-dlPFC functional connectivity as readout for conflict-related executive deficitSummaryExecutive dysfunction is prominent feature of and may drive core symptoms. Dorsolateral prefrontal cortex (dlPFC) deficits have been linked dysfunction, but mechanistic details critical treatment development remain unclear. Here, capitalizing on recent animal...
Abstract Gene expression evolution through gene regulatory network (GRN) changes has gained appreciation as a driver of morphological evolution. However, understanding how GRNs evolve is hampered by finding relevant cis -regulatory element (CRE) mutations, and interpreting the protein-DNA interactions they alter. We investigated evolutionary in duplicated Bric-à-brac (Bab) transcription factors key Bab target GRN underlying novel dimorphic pigmentation D. melanogaster its relatives. It...