A5045575883- Biomedical Text Mining and Ontologies
- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Particle Dynamics in Fluid Flows
- Nuclear and radioactivity studies
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Radioactive contamination and transfer
- Microbial Community Ecology and Physiology
- Infection Control and Ventilation
- Computational Drug Discovery Methods
- Biosensors and Analytical Detection
- Bioinformatics and Genomic Networks
- Marine and coastal ecosystems
- Genomics and Rare Diseases
- Parasitic Diseases Research and Treatment
- Marine Biology and Ecology Research
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- Combustion and Detonation Processes
- Parasites and Host Interactions
- Bacterial Infections and Vaccines
- Cancer Genomics and Diagnostics
- COVID-19 epidemiological studies
- Genomic variations and chromosomal abnormalities
Texas A&M University
2022-2025
Harbin Medical University
2024-2025
Gram-negative bacteria pose an increased threat to public health because of their ability evade the effects many antimicrobials with growing antibiotic resistance globally. One key component gram-negative is functionality and cells' repair outer membrane (OM) which acts as a barrier for cell external environment. The biosynthesis lipids, particularly lipopolysaccharides, or lipooligosaccharides (LPS/LOS) essential OM repair. Here we show phenotypic genotypic changes Escherichia coli MG1655...
Disease Ontology (DO) has been widely studied in biomedical research and clinical practice to describe the roles of genes. DO enrichment analysis is an effective means discover associations between genes diseases. Compared hundreds Gene (GO)-based methods, however, DO-based methods are relatively scarce, most current approaches term-for-term thus unable solve over-enrichment problems caused by "true-path" rule. Here, we a novel double-weighted model, EnrichDO, which leverages latest...
Abstract Biomedical ontologies, such as Gene Ontology (GO), Disease (DO), and the Human Phenotype (HPO), have been extensively applied to characterize molecular roles their semantic relationships in biomedical research clinical practice. Although numerous algorithms developed quantify between ontology terms or explore functions, absence of a comprehensive tool integrate these has limited effective applications. To address this, we OntoTiger, platform Ontology-based application Tools for...
Abstract The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), sparked an international debate on effective ways to prevent and treat the virus. Specifically, there were many varying opinions use of ivermectin (IVM) throughout world, with minimal research support either side. IVM is FDA-approved antiparasitic drug that was discovered in 1970s found show antiviral activity. objective this study examine binding behavior rates association dissociation...
Abstract A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of COVID-19 pandemic that originated in China December 2019. Although extensive research has been performed on SARS-CoV-2, binding behavior spike (S) protein and receptor domain (RBD) SARS-CoV-2 at different environmental conditions have yet to be studied. The objective this study is investigate effect temperature, fatty acids, ions, concentration rates association...
To understand how SARS-CoV-2 spreads indoors, in this study bovine coronavirus was aerosolized as simulant into a plexiglass chamber with coupons of metal, wood and plastic surfaces. After aerosolization, coupon surfaces were swiped to quantify the virus concentrations using quantitative polymerase chain reaction (qPCR). Bio-layer interferometry showed stronger association on metal surfaces, however, higher dissociation from 80% relative humidity. Virus aerosols collected 100 L/min wetted...
Structural variations (SVs) contribute to a large extent genomic diversity and are highly relevant for various human genetic diseases. The sensitivity specificity of SV identification have significantly improved with the development widespread application high-throughput sequencing, making clinical diagnosis treatment more accurate. Therefore, SV4GD (Structural Variation Genetic Diseases, https://bio-computing.hrbmu.edu.cn/SV4GD/), manually curated database, was constructed provide...
Wastewater-based surveillance (WBS) on SARS-CoV-2 has been proved to be an effective approach estimate the prevalence of COVID-19 in communities and cities. However, its application was overlooked at smaller scale, such as a single facility. Meat processing plants are hotspots for outbreaks due their unique environment that favorable survival persistence SARS-CoV-2. This is first known WBS study meat plants. The goal understand temporal variation levels wastewater from plant Canada during...