A5090909903- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Tuberculosis Research and Epidemiology
- Transplantation: Methods and Outcomes
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Respiratory viral infections research
- Infectious Diseases and Mycology
- Organ Transplantation Techniques and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Quinazolinone synthesis and applications
- Microwave-Assisted Synthesis and Applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Organ and Tissue Transplantation Research
- Helicobacter pylori-related gastroenterology studies
- Child Nutrition and Water Access
- Inhalation and Respiratory Drug Delivery
- Folate and B Vitamins Research
- Immunodeficiency and Autoimmune Disorders
The University of Texas Health Science Center at Tyler
2020-2025
The University of Texas at Tyler
2021-2024
Parks Victoria
2023
Nephrologisches Zentrum Goettingen
2023
RELX Group (United States)
2023
Hamilton Health Sciences
2023
Footscray Hospital
2023
Dialyse Centrum Groningen
2023
Cooperative Trials Group for Neuro-Oncology
2023
Saskatoon Medical Imaging
2023
In bronchiectasis, neutrophilic inflammation is associated with an increased risk of exacerbations and disease progression. Brensocatib, oral, reversible inhibitor dipeptidyl peptidase 1 (DPP-1), targets neutrophil serine proteases, key mediators inflammation. a phase 3, double-blind trial, we randomly assigned patients bronchiectasis (in 1:1:1 ratio for adults 2:2:1 adolescents) to receive brensocatib (10 mg or 25 once per day) placebo. The primary end point was the annualized rate...
Formerly regarded as a rare disease, bronchiectasis is increasingly recognised. A renewed interest in this disease has led to significant progress research. Randomised clinical trials (RCTs) have demonstrated the benefits of airway clearance techniques, inhaled antibiotics and long-term macrolide therapy patients. However, heterogeneity remains one most challenging aspects management. Phenotypes endotypes been identified help find “treatable traits” partially overcome complexity. The goals...
Nontuberculous mycobacteria (NTM) are prevalent among patients with bronchiectasis. However, the long-term natural history of NTM and bronchiectasis is not well described.
Bronchiectasis is characterised by uncontrolled neutrophil serine protease (NSP) activity. Cathepsin C (CatC; dipeptidyl peptidase 1) activates NSPs during maturation. CatC inhibitors can potentially reduce neutrophil-mediated lung damage. This Phase II, randomised, double-blind, placebo-controlled trial (AIRLEAF®; NCT05238675 ) evaluated efficacy, safety and optimal dosing of BI 1291583, a novel, reversible inhibitor, in adults with bronchiectasis. In total, 322 participants were randomised...
New therapies are needed to prevent exacerbations, improve quality of life and slow disease progression in bronchiectasis. Inhibition cathepsin C (CatC) activity has the potential decrease activation neutrophil-derived serine proteases patients with bronchiectasis, thereby reducing airway inflammation, improving symptoms, exacerbations preventing further damage. Here we present design a phase 2 trial (Airleaf™; NCT05238675 ) assessing efficacy safety novel CatC inhibitor, BI 1291583, adult...
Alveolar epithelial beta-adrenergic receptor (betaAR) activation accelerates active Na+ transport in lung cells vitro and speeds alveolar edema resolution human tissue normal injured animal lungs. Whether these receptors are essential for fluid clearance (AFC) or if other mechanisms sufficient to regulate is unknown. In this study, we report that mice with no beta1- beta2-adrenergic (beta1AR-/-/beta2AR-/-) have reduced distal Na,K-ATPase function diminished basal amiloride-sensitive AFC....
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