- Supramolecular Self-Assembly in Materials
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Curcumin's Biomedical Applications
- Alzheimer's disease research and treatments
- Advanced Sensor and Energy Harvesting Materials
- Fluoride Effects and Removal
- RNA Research and Splicing
- Shoulder and Clavicle Injuries
- RNA and protein synthesis mechanisms
- Toxic Organic Pollutants Impact
- Orthopedic Surgery and Rehabilitation
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- Glycosylation and Glycoproteins Research
- Shoulder Injury and Treatment
- Protein Structure and Dynamics
- Per- and polyfluoroalkyl substances research
- Crystallography and molecular interactions
- Enzyme Structure and Function
- Machine Learning in Bioinformatics
Texas A&M University
2018-2021
The aggregation of amyloid-β (Aβ) peptides into senile plaques is a hallmark Alzheimer's disease (AD) and hypothesized to be the primary cause AD related neurodegeneration. Previous studies have shown ability curcumin both inhibit Aβ oligomers or fibrils reduce amyloids in vivo. Despite promise its derivatives serve as diagnostic, preventative, potentially therapeutic molecules, mechanism by which bind fibrils' formation remains elusive. Here, we investigated set complex with hexamer peptide...
The oxidation of RNA has been implicated in the development many diseases. Among four ribonucleotides, guanosine is most susceptible to oxidation, resulting formation 8-oxo-7,8-dihydroguanosine (8-oxoG). Despite limited knowledge about how cells regulate detrimental effects oxidized RNA, cellular factors involved its regulation have begun be identified. One these polynucleotide phosphorylase (PNPase), a multifunctional enzyme turnover. In present study, we examined interaction PNPase with...
An amino acid complexes with metal ions in a manner similar to EDTA, showing significant catalytic and piezoelectric properties. The results suggest that metabolic molecules can be developed as EDTA-mimic bio-chelators for various applications.
Functional amyloid materials can combine the self-assembly of peptide scaffolds into fibrils with binding capacities for ions or compounds pharmaceutical interest, endowed by mutable non-β-sheet-forming residues at termini. Herein, we report first to our knowledge materials, encompassing a GAIIG amyloidogenic core, which bind Alzheimer's disease (AD) drugs, mimicking mechanism same AD drugs enzymes according experimentally resolved structures, including target enzyme acetylcholinesterase...
ADVERTISEMENT RETURN TO ISSUEPREVErratumNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Interactions between Curcumin Derivatives and Amyloid-β Fibrils: Insights from Molecular Dynamics Simulations"Joseph M. JakubowskiJoseph JakubowskiMore by Joseph Jakubowski, Asuka A. OrrAsuka OrrMore Orr, Doan LeDoan LeMore Le, Phanourios Tamamis*Phanourios TamamisMore Tamamishttp://orcid.org/0000-0002-3342-2651Cite this: J. Chem. Inf. Model. 2020, 60, 8, 4108Publication Date (Web):July 23,...