A5057397472- Tuberculosis Research and Epidemiology
- Bone Tissue Engineering Materials
- Biochemical and Molecular Research
- Tissue Engineering and Regenerative Medicine
- Mycobacterium research and diagnosis
- 3D Printing in Biomedical Research
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Silk-based biomaterials and applications
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Acupuncture Treatment Research Studies
- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Genetic and phenotypic traits in livestock
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Wound Healing and Treatments
- High Altitude and Hypoxia
- Immune Response and Inflammation
- Chromatin Remodeling and Cancer
Shanghai Jiao Tong University
2019-2024
Shanghai Ninth People's Hospital
2019-2024
Stomatology Hospital
2022-2024
Shandong Provincial Hospital
2019-2024
Shandong First Medical University
2020-2024
Shanghai Stomatological Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
National Clinical Research Center for Digestive Diseases
2022-2023
National Clinical Research
2023
Sichuan Academy Of Social Sciences
2021
Abstract The redevelopment/regeneration pattern of amputated limbs from a blastema in salamander suggests that enhanced regeneration might be achieved by mimicking the developmental microenvironment. Inspired discovery expression magnesium transporter‐1 (MagT1), selective (Mg) transporter, is significantly upregulated endochondral ossification region mouse embryos, Mg‐enriched 3D culture system proposed to provide an embryonic‐like environment for stem cells. First, optimum concentration Mg...
Type II diabetes mellitus (TIIDM) remains a challenging clinical issue for both dentists and orthopedists. By virtue of persistent hyperglycemia altered host metabolism, the pathologic diabetic micromilieu with chronic inflammation, advanced glycation end products accumulation, attenuated biomineralization severely impairs bone regeneration efficiency. Aiming to "remodel" micromilieu, we 3D-printed bioscaffolds composed Sr-containing mesoporous bioactive glass nanoparticles (Sr-MBGNs)...
The healing process of critical-sized bone defects urges for a suitable biomineralization environment. However, the unsatisfying repair outcome usually results from disturbed intricate milieu and lack in situ mineralization resources. In this work, we have developed composite hydrogel that mimics natural processes serves as seedbed regeneration. oxidized silk fibroin fibrin are incorporated rigid geogrids, amorphous calcium phosphate (ACP) platelet-rich plasma serve fertilizers loam,...
Protein lysine succinylation, an emerging protein post-translational modification widespread among eukaryotic and prokaryotic cells, represents important regulator of cellular processes. However, the extent function succinylation in Mycobacterium tuberculosis, especially extensively drug-resistant strain, remain elusive. Combining protein/peptide prefractionation, immunoaffinity enrichment, LC-MS/MS analysis, a total 686 succinylated proteins 1739 sites M. tuberculosis were identified,...
Periodontitis is a prevalent dental disease marked by progressive destruction of tooth-supporting tissues, and the recovery bone defects after periodontitis remains challenging. Although stem cell-based therapy promising treatment for periodontal tissue regeneration, function mesenchymal cells constantly impaired inflammatory microenvironment, leading to compromised outcomes. Herein, calcitonin gene-related peptide (CGRP)-loaded porous microspheres (PMs) are prepared protect marrow (BMSCs)...
The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired discovery that endoplasmic reticulum (ER) a state excessive stress and dysfunction under hyperglycemia, leading to osteogenic disorder, novel engineered exosome proposed modulate ER homeostasis for restoring function mesenchymal stem cells (MSCs). results indicate constructed exosomes efficiently regulate dramatically facilitate MSCs...
Abstract Senile wound healing risks a variety of health complications and makes both economic psychological burdens on patients greatly. Poor activity aged dermal fibroblasts (A‐FBs) local disordered immunoreaction in the deep dermis contribute to delayed healing. Therefore, locally complex microenvironment requires additional processing. Herein, novel double‐layer hyaluronic acid methacrylate (HAMA)/polyvinyl alcohol (PVA) microneedle patch (MNP) coated by young fibroblast‐derived exosomes...
Abstract High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we use sheep as an animal model for low-to-high altitude translocation. We generate multi-omics data including whole-genome sequences, time-resolved bulk RNA-Seq, ATAC-Seq and single-cell RNA-Seq from multiple tissues well phenotypic 20 bio-indicators. characterize transcriptional changes of all genes each...
Small cell lung cancer (SCLC) is a rapidly progressing, incurable that frequently spreads to bone. New insights are needed identify therapeutic targets prevent or retard SCLC metastatic progression. Human SBC-5 cells in mouse xenograft models home skeletal and nonskeletal sites, whereas human SBC-3 only pervade sites. Because microRNAs (miRNA) often act as tumor regulators, we investigated their role preclinical of SCLC. miRNA expression profiling revealed selective reduced (miR)-335 miR-29a...
Bromodomain-containing protein 9 (BRD9), a component of non-canonical BAF chromatin remodeling complex, has been identified as critical therapeutic target in hematological diseases. Despite the hematopoietic origin osteoclasts, role BRD9 osteoclastogenesis and bone diseases remains unresolved. Here, we show Brd9 deficiency myeloid lineage enhances osteoclast commitment resorption through downregulating interferon-beta (IFN-β) signaling with released constraint on osteoclastogenesis. Notably,...
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue sarcomas accounting for 3%–10% of all sarcomas. Neurofibromatosis type 1 (NF1) is the most important known risk factor. MPNSTs often diagnosed at an advanced stage when distant metastases have developed. Although surgical resection remains main treatment MPNSTs, complete rarely possible. The prognosis patients with poor. There urgent need improved therapies. To this end, we investigated whether microRNA...
Abstract M. tuberculosis is intrinsically tolerant to many antibiotics largely due the imperviousness of its unusual mycolic acid-containing cell wall most antimicrobials. The emergence and increasingly widespread multidrug-resistant (MDR-TB) extensively drug-resistant (XDR-TB) revitalized keen interest in phage-inspired therapy. SWU1gp39 a novel gene from mycobacteriophage SWU1 with unknown function. expressed smegmatis conferred host increased susceptibility multiple antibiotics, including...
Abstract Wound healing impairment in diabetes mellitus is associated with an excessive inflammatory response and defective regeneration capability suppressed Hedgehog (Hh) signaling. The bromodomain protein BRD9, a subunit of the non‐canonical BAF chromatin‐remodeling complex, critical for macrophage response. However, whether epigenetic drug BRD9 degrader can attenuate sustained state wounds remains unclear. Without bona fide immune microenvironment, Hh signaling activation fails to...
Liver metastasis is one of the leading causes death in colorectal cancer (CRC) patients. The present study aimed to evaluate value eIF4E as a prognostic marker liver (CLM) and identify functional role CRC metastasis.The expression level tissues was analyzed by immunohistochemical staining Western blot. Expression cell lines evaluated reverse transcription quantitative polymerase chain reaction (RT-qPCR) Cell Counting Kit-8 (CCK-8) Transwell assays were performed assess effects on...
AIM:To investigate semaphorin 4D (Sema4D) and hypoxia-inducible factor-1α (HIF-1α) expression in colorectal carcinoma evaluate their clinicopathological prognostic significance.
The immune escape of colon cancer and its role in the response to immunotherapies such as PD-1/PD-L1 checkpoint inhibitors have long been great interest. positive outcomes immunotherapy are limited by immunosuppressive nature tumor microenvironment. Integrin αvβ6, which can regulate progression cancer, was recently reported be involved suppression cancer. In present study, we explored correlation between αvβ6 PD-L1 expression immunohistochemistry tissues. Then, regulation signaling cells...