A5068126379- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Plant Virus Research Studies
- Plant Disease Resistance and Genetics
- Genetic Mapping and Diversity in Plants and Animals
- Adipose Tissue and Metabolism
- Plant responses to elevated CO2
- RNA Research and Splicing
- High Altitude and Hypoxia
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Pesticide and Herbicide Environmental Studies
- RNA and protein synthesis mechanisms
- Plant Pathogenic Bacteria Studies
- Lipid metabolism and biosynthesis
- Genetic diversity and population structure
- Plant Disease Management Techniques
- Lipid metabolism and disorders
- Chromosomal and Genetic Variations
- Plant nutrient uptake and metabolism
- Plant and Fungal Interactions Research
- Soil Carbon and Nitrogen Dynamics
Shanxi Academy of Medical Sciences
2025
Shanxi Medical University
2025
China Agricultural University
2010-2024
Dalian Medical University
2023
Ministry of Agriculture and Rural Affairs
2020
Henan Academy of Agricultural Sciences
2015-2016
Rural Development Institute
2016
Understanding the genetic mechanisms of phenotypic variation in hybrids between domestic animals and their wild relatives may aid germplasm innovation. Here, we report high-quality genome assemblies a male Pamir argali ( O . ammon polii , 2 n = 56), female Tibetan sheep aries 54), hybrid sheep, high-throughput sequencing 425 ovine animals, including sheep. We detected genomic synteny Chromosome two acrocentric chromosomes argali. revealed consistent satellite repeats around chromosome...
The fat tail of sheep is an important organ that has evolved to adapt extreme environments. However, the genetic mechanisms underlying phenotype remain poorly understood. Here, we characterize transcriptome and lipidome profiles morphological changes in 250 adipose tissues from two thin-tailed three fat-tailed populations summer winter. We implement whole-genome selective sweep tests identify variants related fat-tails. a set functional genes show differential expression These are...
Abstract High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we use sheep as an animal model for low-to-high altitude translocation. We generate multi-omics data including whole-genome sequences, time-resolved bulk RNA-Seq, ATAC-Seq and single-cell RNA-Seq from multiple tissues well phenotypic 20 bio-indicators. characterize transcriptional changes of all genes each...
Abstract Background Ketosis is a common metabolic disease during the transition period in dairy cattle, resulting long-term economic loss to industry worldwide. While genetic selection of resistance ketosis has been adopted by many countries, and biological basis underlying poorly understood. Results We collected total 24 blood samples from 12 Holstein cows, including 4 healthy 8 ketosis-diagnosed ones, before (2 weeks) after (5 days) calving, respectively. then generated RNA-Sequencing...
Abstract Background Cross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited model organisms with relatively small sample sizes. Results Here, we systematically analyze compare 10,830 4866 publicly available RNA-seq samples in humans cattle, respectively, representing 20 common tissues. Focusing on 17,315 orthologous genes, demonstrate...
Abstract Characterization of genetic regulatory variants acting on the transcriptome livestock is essential for interpreting molecular mechanisms underlying traits economic value and increasing rate gain through artificial selection. Here, we build a cattle Genotype-Tissue Expression atlas (cattle GTEx, http://cgtex.roslin.ed.ac.uk/ ) as part pilot phase Farm animal GTEx (FarmGTEx) project research community based publicly available 11,642 RNA-Seq datasets. We describe landscape across over...
The influence of various concentrations imazapic residues (0-800 μg kg-1) on the growth, chlorophyll content, and photosynthetic characteristics maize seedlings was studied in a greenhouse pot experiment. Plant height, root length, shoot dry mass, total mass declined with increase residue concentrations. root/shoot ratio initially decreased then increased presence imazapic, which indicated that effects plant height length might differ seedlings. Lowered content net rate were observed leaves...
The influence of various concentrations imazapic residues (0-800 μg kg-1) on the growth, chlorophyll content, and photosynthetic characteristics maize seedlings was studied in a greenhouse pot experiment. Plant height, root length, shoot dry mass, total mass declined with increase residue concentrations. root/shoot ratio initially decreased then increased presence imazapic, which indicated that effects plant height length might differ seedlings. Lowered content net rate were observed leaves...
Abstract High-altitude hypoxia acclimatization requires whole-body physiological regulation in highland immigrants, but the underlying genetic mechanism has not been clarified. Here we used sheep as an animal model for plain-to-plateau transplantation. We generated multi-omics data including time-resolved bulk RNA-Seq, ATAC-Seq and single-cell RNA-Seq from multiple tissues well phenotypic 20 bio-indicators. characterized transcriptional changes of all genes each tissue, examined multi-tissue...
Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome diversity. Aberrant regulation alternative produces with different structures can lead altered protein function, inactivation, or deleterious variants, which have severe effects on normal cellular leading many diseases, including cancer. abnormalities are often found in so highly correlated diseases treatment. According relevant statistics, breast cancer an important factor that threatens...