A5025069565- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Plant Parasitism and Resistance
- Mycorrhizal Fungi and Plant Interactions
- Pluripotent Stem Cells Research
- Hippo pathway signaling and YAP/TAZ
- Plant tissue culture and regeneration
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Acute Kidney Injury Research
- Metabolism, Diabetes, and Cancer
- Plant nutrient uptake and metabolism
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Insect-Plant Interactions and Control
- Plant Molecular Biology Research
- DNA Repair Mechanisms
- Electrolyte and hormonal disorders
- Growth Hormone and Insulin-like Growth Factors
- Neuroscience and Neural Engineering
- Epigenetics and DNA Methylation
- Heat shock proteins research
- Plant and animal studies
- TGF-β signaling in diseases
Northern Jiangsu People's Hospital
2025
University of Illinois Urbana-Champaign
2014-2024
Anhui Academy of Agricultural Sciences
2020-2024
Tea Research Institute
2020-2024
Center for Life Sciences
2012
Tsinghua University
2012
ABSTRACT Nuclear speckles are self-assembled organelles composed of RNAs and proteins. They proposed to act as structural domains that control distinct steps in gene expression, including transcription, splicing mRNA export. Earlier studies identified differential localization a few components within the speckles. It was speculated spatial organization speckle might contribute directly order operations coordinate processes. Here, by performing multi-color structured illumination microscopy,...
Long noncoding RNAs (lncRNAs) are often associated with polysomes, indicating coding potential. However, only a handful of endogenous proteins encoded by putative lncRNAs have been identified and assigned function. Here, we report the discovery gastrointestinal-tract-specific lncRNA ( LINC00675 ) that is regulated pioneer transcription factor FOXA1 encodes conserved small protein 79 amino acids which termed FORCP FO XA1- R egulated C onserved Small P rotein). transcript undetectable in most...
Long non-coding RNAs (lncRNAs) regulate vital biological processes, including cell proliferation, differentiation and development. A subclass of lncRNAs is synthesized from microRNA (miRNA) host genes (MIRHGs) due to pre-miRNA processing, are categorized as miRNA-host gene (lnc-miRHGs). Presently, the cellular function most lnc-miRHGs not well understood. We demonstrate a miRNA-independent role for nuclear-enriched lnc-miRHG in cycle progression. MIR100HG produces spliced stable that display...
Tea has been gaining increasing popularity all over the world in recent years, and its yield quality depend on growth development of tea plants [
Cell cycle is a cellular process that subject to stringent control. In contrast the wealth of knowledge proteins controlling cell cycle, very little known about molecular role lncRNAs (long noncoding RNAs) in cell-cycle progression. By performing genome-wide transcriptome analyses cell-cycle-synchronized cells, we observed phase-specific induction >2000 lncRNAs. Further, demonstrate an S-phase-upregulated lncRNA, SUNO1 , facilitates progression by promoting YAP1-mediated gene expression....
BEN domain-containing proteins are emerging rapidly as an important class of factors involved in modulating gene expression, yet the molecular basis how they regulate chromatin function and transcription remains to be established. BEND3 is a quadruple protein that associates with heterochromatin functions transcriptional repressor. We find highly expressed pluripotent cells, induction differentiation results down-regulation BEND3. The removal from cells exhibiting upregulation...
Adventitious root (AR) formation is the key step for successful cutting propagation of tea plants (Camellia sinensis L.). Studies showed that arbuscular mycorrhizal fungus (AMF) can promote rooting ability, and auxin pathway in basal stem cuttings was involved this process. However, abscisic acid (another important regulator on AR formation) other parts at different stages responding to AMF inoculation are not well studied. Therefore, paper, contents, enzymes genes related these two plant...
Arbuscular mycorrhizal fungus (AMF), forming symbiosis with most terrestrial plants, strongly modulates root system architecture (RSA), which is the main characteristic of in soil, to improve plant growth and development. So far, studies AMF on tea seedlings are few relevant molecular mechanism not deciphered. In this study, 6-month-old cutting cultivar "Wancha No.4" were inoculated an isolate, Rhizophagus intraradices BGC JX04B harvested after 6 months growth. The indexes RSA sugar contents...
Triple-negative breast cancer (TNBC) is one of the most aggressive (BC) subtypes with a poor prognosis and high recurrence rate. Recent studies have identified vital roles played by several lncRNAs (long noncoding RNAs) in BC pathobiology. Cell type-specific expression their potential role regulating oncogenic tumor suppressor genes made them promising drug targets. By performing transcriptome screen an isogenic TNBC/basal subtype progression cell line model, we recently reported ∼1800 that...
Cellular quiescence and cell cycle reentry regulate vital biological processes such as cellular development tissue homeostasis are controlled by precise regulation of gene expression. The roles long noncoding RNAs (lncRNAs) during these remain to be elucidated. By performing genome-wide transcriptome analyses, we identify differential expression several hundreds lncRNAs, including a significant number the less-characterized class microRNA-host-gene ( MIRHG ) lncRNAs or lnc- MIRHGs , in human...
Introduction Adventitious root (AR) development, affected by various biotic and abiotic factors, is the most important procedure in tea plant ( Camellia sinensis L.) cutting propagation. Establishing symbiotic relationships with terrestrial plants, AMF (Arbuscular mycorrhizal fungus) can mediate AR formation of several herbaceous woody plants previous studies. Methods In this paper, effects combined application exogenous auxin on cuttings from different varieties (‘Pingyangtezao’, ‘Longjing...
Abstract Hypoxia-induced alternative splicing (AS) regulates tumor progression and metastasis. Little is known about how such AS controlled whether higher-order genome nuclear domain (ND) organizations dictate these processes. We observe that hypoxia-responsive alternatively spliced genes position near speckle (NS), the ND enhances efficiency. NS-resident MALAT1 long noncoding RNA, induced in response to hypoxia, AS. achieves this by organizing SR-family of factor, SRSF1, NS regulating...
Telomeres are maintained by telomerase or in a subset of cancer cells homologous recombination (HR)-based mechanism, Alternative Lengthening (ALT). The mechanisms regulating telomere-homeostasis ALT remain unclear. We report that replication initiator protein, Origin Recognition Complex-Associated (ORCA/LRWD1), localizing at the ALT-telomeres, modulates HR activity. ORCA's localization to ALT-telomeres is facilitated its interaction SUMOylated shelterin components. loss ORCA ALT-positive...
Being one of the most disastrous pierce-sucking pests tea plants [Camellia sinensis (L.) O. Kuntze], green leafhopper (Empoasca onukii Matsuda) greatly affects yield and quality. In this paper, correlations among leaf structure, biochemical components occurrence in cultivars with larger planting area were deeply analyzed, aiming to find key factor impacting host selectivity leafhopper. Tea cultivar 'Longjing 43', together 'Shuchazao', showed susceptibility pest high polyphenols content. And...