A5004528184- Plant Molecular Biology Research
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- Plant Reproductive Biology
- Immune Cell Function and Interaction
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- T-cell and B-cell Immunology
- Social and Educational Sciences
- Legume Nitrogen Fixing Symbiosis
- Acute Myeloid Leukemia Research
- Protist diversity and phylogeny
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Bacteriophages and microbial interactions
- Virology and Viral Diseases
- Acute Lymphoblastic Leukemia research
- Bioinformatics and Genomic Networks
- Food Waste Reduction and Sustainability
- Invertebrate Immune Response Mechanisms
- Migration, Health and Trauma
- Protein Degradation and Inhibitors
- Genomic variations and chromosomal abnormalities
- Inflammasome and immune disorders
- FinTech, Crowdfunding, Digital Finance
Japan Science and Technology Agency
2023
Austrian Academy of Sciences
2015-2023
Medical University of Vienna
2023
The University of Tokyo
2023
Gregor Mendel Institute of Molecular Plant Biology
2017-2023
Institute of Molecular Biotechnology
2023
Vienna Biocenter
2014-2021
University of Gothenburg
2020
Research Institute of Molecular Pathology
2012-2017
European Molecular Biology Organization
2011
The transcription factor EBF1 is essential for lineage specification in early B cell development. In this study, we demonstrate by conditional mutagenesis that required commitment, pro–B development, and subsequent transition to the pre–B stage. Later was generation maintenance of several mature types. Marginal zone B-1 cells were lost, whereas follicular (FO) germinal center (GC) reduced absence EBF1. Activation receptor resulted impaired intracellular signaling, proliferation survival...
NK cells can be grouped into distinct subsets that are localized to different organs and exhibit a capacity secrete cytokines mediate cytotoxicity. Despite these hallmarks reflect tissue-specific specialization in cells, little is known about the factors control development of subsets. The basic leucine zipper transcription factor Nfil3 (E4bp4) essential for bone marrow-derived cell development, but it not clear whether equally important all or how induces lineage commitment. In this...
Alternation between morphologically distinct haploid and diploid life forms is a defining feature of most plant algal cycles, yet the underlying molecular mechanisms that govern these transitions remain unclear. Here, we explore dynamic relationship chromatin accessibility epigenetic modifications during form in Arabidopsis. The diploid-to-haploid transition governed by loss H3K9me2 DNA demethylation transposon-associated cis -regulatory elements. This event associated with dramatic changes...
How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance histone variants organization chromatin we investigated how assemble Arabidopsis thaliana genome. We showed that a limited number states divide euchromatin heterochromatin into several subdomains. found are as significant determining composition states. Particularly strong associations were observed between H2A specific combinations modifications....
The mobility of transposable elements (TEs) contributes to evolution genomes. Their uncontrolled activity causes genomic instability; therefore, expression TEs is silenced by host are marked with DNA and H3K9 methylation, which associated silencing in flowering plants, animals, fungi. However, distantly related groups eukaryotes, H3K27me3 deposited the Polycomb repressive complex 2 (PRC2), an epigenetic mark gene plants animals. direct PRC2 has so far only been shown one species ciliates. To...
Chromatin regulation of eukaryotic genomes depends on the formation nucleosome complexes between histone proteins and DNA. Histone variants, which are diversified by sequence or expression pattern, can profoundly alter chromatin properties. While variants in H2A H3 families well characterized, extent diversification H2B is less understood. Here, we report a systematic analysis family plants, have undergone substantial divergence during evolution each major group plant kingdom. By...
Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling have been extensively studied in animals, however it is unknown how generalizable these are to diverse eukaryotes. Here, we use the haploid plant
Innate immune signalling pathways are evolutionarily conserved between invertebrates and vertebrates. The analysis of NF-ĸB in <i>Drosophila</i> has contributed important insights into how organisms respond to infection. Nevertheless, significant gaps remain our understanding the activation intracellular elicits specific transcriptional programs. Here we report a genome-wide RNA interference survey for transcription factors that required Toll-dependent responses. In addition...
Summary How histone variants and modifications shape nucleosome-mediated transcriptional repression, how activity shapes the enrichment of remain unclear. To clarify these relationships, we examined chromatin organization in Arabidopsis thaliana genome, identifying a limited number landscapes that distinguish transposon families distinct groups genes based on their regulation. Unexpectedly, H2A are strong determinants landscape architecture. Combinations H2A.W four define six domains...
Summary Recent studies have shown that correlations between chromatin modifications and transcription vary among eukaryotes. This is the case for marked differences of moss Physcomitrium patens liverwort Marchantia polymorpha . Mosses liverworts diverged from hornworts, altogether forming lineage bryophytes shared a common ancestor with land plants. We aimed to describe in hornworts establish synapomorphies across approach definition ancestral organization used genomic methods define 3D map...
Systematic measurement of genetic interactions by combinatorial RNAi (co-RNAi) is a powerful tool for mapping functional modules and discovering components. It also provides insights into the role epistasis on way from genotype to phenotype. The interpretation co-RNAi data requires computational statistical analysis in order detect reliably sensitively. We present comprehensive approach univariate phenotype measurements, such as cell growth. method based quantitative model demonstrated two...
Abstract Extended pedigrees are not only very useful to identify disease genes for rare Mendelian conditions, but they may also help unravel the genetics of complex diseases such as schizophrenia. In this study we performed genome‐wide multipoint non‐parametric linkage (NPL) score calculations using 825 microsatellites and 5,366 single nucleotide polymorphisms (SNPs), respectively, searched haplotypes shared by affected individuals, in three multiplex families including 29 genotyped...
Summary The mobility of transposable elements (TEs) contributes to evolution genomes 1,2 . Meanwhile, their uncontrolled activity causes genomic instability and therefore expression TEs is silenced by host 3,4 are marked with DNA H3K9 methylation that associated silencing in flowering plants 5 , animals, fungi 6 Yet, distantly related eukaryotes instead H3K27me3 deposited the Polycomb Repressive Complex 2 (PRC2) 7–11 an epigenetic mark gene multicellular 12–15 It was proposed ancestral PRC2...
The somatic DNA molecules of spirotrichous ciliates are present as linear chromosomes containing mostly single-gene coding sequences with short 5' and 3' flanking regions. Only a few conserved motifs have been found in the DNA. Motifs that may play roles promoting and/or regulating transcription not consistently detected. Moreover, comparing subtelomeric regions 1,356 end-sequenced failed to identify more putatively motifs.We sequenced compared RNA versions polymerase alpha (pol alpha) gene...