A5101967072- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Pregnancy and preeclampsia studies
- Esophageal and GI Pathology
- Preterm Birth and Chorioamnionitis
- Eosinophilic Esophagitis
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy-related medical research
- Birth, Development, and Health
- Helicobacter pylori-related gastroenterology studies
- Maternal and fetal healthcare
- Pancreatitis Pathology and Treatment
- Gastroesophageal reflux and treatments
- Gallbladder and Bile Duct Disorders
- Cardiovascular Issues in Pregnancy
- Maternal and Perinatal Health Interventions
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lung Cancer Diagnosis and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Ureteral procedures and complications
- Colorectal Cancer Screening and Detection
University of Jammu
2025
Jammu Hospital
2019-2023
Rotunda – The Center for Human Reproduction
2022
Southend University Hospital NHS Foundation Trust
2017-2021
King's College London
2018
King's College Hospital
2005-2018
Chinese University of Hong Kong
2018
Hospiten Group
2018
University College London
2018
Homerton University Hospital
2018
Preterm preeclampsia is an important cause of maternal and perinatal death complications. It uncertain whether the intake low-dose aspirin during pregnancy reduces risk preterm preeclampsia.In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high for to receive aspirin, a dose 150 mg per day, or placebo from 11 14 weeks gestation until 36 gestation. The primary outcome was delivery before 37 analysis performed...
Previous randomized trials have shown that progesterone administration in women who previously delivered prematurely reduces the risk of recurrent premature delivery. Asymptomatic found at midgestation to a short cervix are greatly increased for spontaneous early preterm delivery, and it is unknown whether this such women.
ABSTRACT Objective To examine the performance of screening for preterm and term pre‐eclampsia (PE) in study population participating ASPRE (Combined Multimarker Screening Randomized Patient Treatment with Aspirin Evidence‐Based Preeclampsia Prevention) trial. Methods This was a prospective first‐trimester multicenter on PE 26 941 singleton pregnancies by means an algorithm that combines maternal factors, mean arterial pressure, uterine artery pulsatility index serum pregnancy‐associated...
ABSTRACT Objective To test the hypothesis that performance of first‐trimester screening for pre‐eclampsia (PE) by a method uses Bayes' theorem to combine maternal factors with biomarkers is superior defined current National Institute Health and Care Excellence (NICE) guidelines. Methods This was prospective multicenter study (screening program (SPREE)) in seven Service maternity hospitals England, women recruited between April December 2016. Singleton pregnancies at 11–13 weeks' gestation...
ABSTRACT Objective To examine the diagnostic accuracy of a previously developed model for prediction pre‐eclampsia ( PE ) by combination maternal factors and biomarkers at 11–13 weeks' gestation. Methods This was prospective first‐trimester multicenter study screening in 8775 singleton pregnancies. A published algorithm used calculation patient‐specific risk each individual. The detection rates DRs false‐positive FPRs delivery with < 32, 37 ≥ weeks were estimated compared those dataset...
ABSTRACT Objectives To examine the effect of first‐trimester screening for pre‐eclampsia (PE) on prediction delivering a small‐for‐gestational‐age (SGA) neonate and prophylactic use aspirin prevention SGA. Methods The data this study were derived from two multicenter studies. In SPREE, we investigated performance PE by combination maternal characteristics biomarkers at 11–13 weeks' gestation. ASPRE, women with singleton pregnancy identified combined as being high risk preterm (> 1 in 100)...
Background: Effective screening for term preeclampsia is provided by a combination of maternal factors with measurements mean arterial pressure, serum placental growth factor, and soluble fms-like tyrosine kinase-1 at 35 to 37 weeks gestation, detection rate ≈75% screen-positive 10%. However, there no known intervention reduce the incidence disease. Methods: In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1120 women singleton pregnancies high risk receive...
Fetal Medicine Foundation Second Trimester Screening Group, Harris Birthright Research Centre for Medicine, King's College Hospital Medical School, Denmark Hill, London, UK
ABSTRACT Objective To report the incidence of preterm pre‐eclampsia (PE) in women who are screen positive according to criteria National Institute for Health and Care Excellence (NICE) American College Obstetricians Gynecologists (ACOG), compare with that those or negative by The Fetal Medicine Foundation (FMF) algorithm. Methods This was a secondary analysis data from ASPRE study. study population consisted singleton pregnancy underwent prospective screening PE means FMF algorithm, which...
(Abstracted from N Engl J Med 2017;377:613–622) Since 1979, multiple studies have shown that low-dose aspirin in pregnancy can lower the occurrence of preeclampsia. Subsequent doses greater than 100 mg/d started before 16 weeks gestation are most effective.
To examine the predictive performance of a previously reported competing-risks model screening for pre-eclampsia (PE) at 35-37 weeks' gestation by combinations maternal risk factors, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in validation dataset derived from screened population STATIN study.This was prospective third-trimester multicenter study PE singleton pregnancies means...
To evaluate the relationship between impedance to flow in uterine arteries at 22-24 weeks and subsequent spontaneous delivery before 33 weeks.The pulsatility index (PI) was measured by transvaginal sonography 33,629 women with singleton pregnancies attending for routine antenatal care. The distribution of PI 237 patients live births weeks, after onset labor, compared that 31,633 or median artery mean significantly higher those delivering than weeks. 1.57, which is 95th centile, 1525 (4.8%)...
Changes in circulating levels of maternal serum transforming growth factor beta-1 (TGF- β 1), collected from 98 women (AGA) at different gestational ages (10–38 weeks) were measured and comparisons made between pregnant nonpregnant controls also 10 with small-for-gestational age (SGA) 7 appropriate-for-gestational fetuses. Maternal TGF- 1 all stages pregnancy higher than those normal healthy adults. The mean SGA pregnancies 34-week gestation (32.5 + 3.2 ng/mL) significantly less AGA (39.2...
( N Engl J Med . 2017;377(7):613–622) Professional associations recommend the prophylactic use of low-dose aspirin (60 to 80 mg d) in pregnant women who are considered be at high risk for preeclampsia. However, some studies suggest that started after 16 weeks gestation does not have a significant benefit, and there remain major challenges identifying this condition.
Although progesterone given prophylactically to women with a history of preterm birth cuts the recurrence rate in half, only about 10% spontaneous early births take place such history. Because asymptomatic who have short cervix mid-gestation are at increased risk delivery, measuring cervical length by ultrasonography 20–24 weeks' gestation has been proposed as way identifying high giving before 37 gestation. In this multicenter randomized trial, was measured transvaginal 20–25 24,620...
Background: Vilazodone is the latest approved antidepressant available in United States. Its dual mechanism of action combines inhibition serotonin transporters while simultaneously partially agonizing serotonin-1a (5-HT1A) receptors. This combined activity results facilitation across brain's serotonergic pathways, which has been termed by authors as that a partial agonist and reuptake inhibitor, or SPARI. Objective: The to review laboratory, animal model data, human trial data synthesize...
Objectives. Liver biopsy is performed for various indications in dialysis patients. Being a less-common subset, the hepatic pathology renal not well documented. Idiopathic noncirrhotic portal hypertension (INCPH) clinical entity associated with unexplained and/or spectrum of histopathological vascular changes liver. After encountering INCPH and 2 patients, we sought to further investigate this noteworthy association. Materials methods. A random search patients on hemodialysis or peritoneal...
Universal agreement on the inclusion of intestinal metaplasia to diagnose Barrett's esophagus (BE) is lacking. Our aim was determine association and its density with prevalence dysplasia/cancer in columnar lined (CLE). Patients CLE but no (CLE-no IM) were identified by querying clinical pathology database using SNOMED codes for distal esophageal biopsies. CLE-IM patients from a prospectively maintained BE patients. Subsequently, relative risks prevalent dysplasia cancer calculated. Since...