A5100392303- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Fluorine in Organic Chemistry
- Catalytic C–H Functionalization Methods
- Luminescence and Fluorescent Materials
- Asymmetric Synthesis and Catalysis
- Nanoplatforms for cancer theranostics
- Synthetic Organic Chemistry Methods
- Synthesis and Catalytic Reactions
- RNA and protein synthesis mechanisms
- Antimicrobial Peptides and Activities
- Analytical Chemistry and Chromatography
- Microbial Natural Products and Biosynthesis
- Supramolecular Self-Assembly in Materials
- Radical Photochemical Reactions
- Asymmetric Hydrogenation and Catalysis
- Crystal structures of chemical compounds
- Biochemical and Structural Characterization
- Advanced Synthetic Organic Chemistry
- Protein Structure and Dynamics
- Supramolecular Chemistry and Complexes
- Crystallography and molecular interactions
- Catalytic Cross-Coupling Reactions
- Metabolism and Genetic Disorders
Shaanxi University of Technology
2024
University of Göttingen
2017-2022
Menlo School
2021
Universität Hamburg
2021
Hamburg University of Technology
2021
Shenzhen Institutes of Advanced Technology
2015-2020
Chinese Academy of Sciences
2015-2020
Institute for Biomedicine
2020
Renji Hospital
2019
Shanghai Jiao Tong University
2011-2019
Abstract Secondary C(sp 3 )−H arylations were accomplished by palladium catalysis with triazoles as peptide bond isosteres. The unique power of this approach is highlighted the possibility achieving secondary functionalizations on terminal peptides well unprecedented positional‐selective functionalization internal positions, setting stage for modular late‐stage diversification.
Abstract Late‐stage BODIPY diversification of structurally complex amino acids and peptides was accomplished by racemization‐free palladium‐catalyzed C(sp 3 )−H activation. Transformative fluorescence modification proved viable triazole‐assisted arylation in a chemo‐ site‐selective fashion, providing modular access to novel peptide sensors.
Fungal infections caused by Candida species are among the most prevalent in hospitalized patients. However, current methods for detection of fungal cells clinical samples rely on time-consuming assays that hamper rapid and reliable diagnosis. Herein, we describe rational development new Phe-BODIPY amino acids as small fluorogenic building blocks their application to generate fluorescent antimicrobial peptides labelling urine. We have used computational analyse behaviour BODIPY-substituted...
Late-stage C-H glycosylations of structurally complex amino acids and peptides were accomplished by means racemization-free manganese(I)-catalyzed activation. Thus, glycosylative modifications proved to be viable a linch-pin approach, featuring chemo- site-selective transformations. The peptide-saccharide conjugation provided modular access glycopeptides, likewise enabling the assembly fluorescent-labelled glycopeptides.
Coibamide A is a highly potent antiproliferative cyclodepsipeptide originally isolated from Panamanian marine cyanobacterium. Herein we report an efficient solid-phase strategy for assembly of N-methylated cyclodepsipeptides, which invaluable in generating coibamide derivatives structure–activity relationship studies. As consequence our synthetic studies, two stereochemical assignments were revised and the total synthesis this natural compound was achieved first time.
Abstract Secondary C(sp 3 )−H arylations were accomplished by palladium catalysis with triazoles as peptide bond isosteres. The unique power of this approach is highlighted the possibility achieving secondary functionalizations on terminal peptides well unprecedented positional‐selective functionalization internal positions, setting stage for modular late‐stage diversification.
Abstract Late‐stage BODIPY diversification of structurally complex amino acids and peptides was accomplished by racemization‐free palladium‐catalyzed C(sp 3 )−H activation. Transformative fluorescence modification proved viable triazole‐assisted arylation in a chemo‐ site‐selective fashion, providing modular access to novel peptide sensors.
A type of aromatic helical capsules was synthesized. The crystal structure proved an inner cavity that could perform switchable encapsulation and release potassium ion through protonation/deprotonation-mediated extension contraction molecular motion.
Abstract Glycine cleavage system (GCS) plays a central role in one‐carbon (C1) metabolism and receives increasing interest as core part of the recently proposed reductive glycine pathway (rGlyP) for assimilation CO 2 formate. Despite decades research, GCS has not yet been well understood kinetic data are barely available. This is to large degree because complexity GCS, which composed four proteins (H, T, P, L) catalyzes reactions involving different substrates cofactors. In vitro kinetics...
The novel dipeptide β-turn mimetic, 4,8-disubstituted azabicyclo[4.3.0]nonane amino acid ester (15), has been synthesized to serve as a peptide mimetic of the Phe-Arg, which contains two important pharmacophore elements in melanotropin peptides. Introduction side-chain functionality at C-8 was achieved by using β-functionalized pyroglutamate (8) synthetic precursor. side chain C-4 introduced bromination dehydroamino intermediate (10) followed Suzuki cross-coupling.
Hydrogen-bonded zippers bearing terminal alkene groups were treated with Grubbs' catalyst, leading to covalently cross-linked without violating H-bonding sequence specificity. The yield of a zipper depended on the stability its H-bonded precursor, weakly associating pair giving reasonable yields only at high concentrations while strongly pairs showed nearly quantitative yields. integration thermodynamic (H-bonding) and kinetic (irreversible C═C bond formation) processes suggests possibility...
A [bmIm]OH-catalyzed amidation of azides and aldehydes is reported. The overall transformation involves azide–enolate cycloaddition, which subsequently undergoes rearrangement to give amides.
Gymnopeptides A and B are unprecedented highly N-methylated cyclic β-hairpin octadecapeptides with striking antiproliferative activities isolated from the mushroom Gymnopus fusipes. Using Fmoc-based solid-phase peptide synthesis, followed by macrolactamization of resulting linear peptides, first total synthesis gymnopeptides was successfully achieved in this study. The coupling methods used for cyclization were optimized, configuration Ser1/Thr1 residue gymnopeptide A/B determined to be l.
Abstract Arylated cyclobutanes were accessed by a versatile palladium‐catalyzed secondary C(sp 3 )−H activation, exploiting chelation assistance modular triazoles. The C−H arylation led to cyclobutane natural product derivatives in highly regioselective fashion, setting the stage for easy access novel fluorogenic boron‐dipyrrin (BODIPY)‐labeled probes live‐cell imaging.