A5054408379- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Neurogenetic and Muscular Disorders Research
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Genetic Syndromes and Imprinting
- Energy Harvesting in Wireless Networks
- Childhood Cancer Survivors' Quality of Life
- Airway Management and Intubation Techniques
- Adolescent and Pediatric Healthcare
- Family and Patient Care in Intensive Care Units
- RNA modifications and cancer
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Infant Development and Preterm Care
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular and Diving-Related Complications
- Congenital Anomalies and Fetal Surgery
- Mobile Health and mHealth Applications
- Ethics and Legal Issues in Pediatric Healthcare
- Tumors and Oncological Cases
- Non-Invasive Vital Sign Monitoring
Bambino Gesù Children's Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2025
Respiratory Clinical Trials
2010-2016
Ospedale Vincenzo Cervello
2015
Boston Children's Hospital
2012-2013
Ospedale dei Bambini Vittore Buzzi
2008
Rationale: Obstructive sleep apnea syndrome (OSAS) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in obese children. Whether OSAS intermittent hypoxia associated with injury pediatric NAFLD is unknown.Objectives: To assess the relationship of NAFLD.Methods: Sixty-five consecutive children biopsy-proven (age, mean ± SD, 11.7 2.1 yr; 58% boys; body mass index z score, 1.93 0.61) underwent a clinical-biochemical assessment standard polysomnography. Insulin sensitivity,...
Objectives Sleep disordered breathing (SDB) is common in patients with Prader–Willi syndrome (PWS) and systematic screening recommended, especially before growth hormone treatment. The aim of the study was to describe baseline SDB therapeutic interventions a large cohort patients. Study design Retrospective study. Subject selection Eighty-eight PWS, median [interquartile range] age 5.1 [1.0–14.5] years old (range 0.3–44.3), who were followed three centers (France, Italy). Methodology...
Children with medical complexity (CMC) are patients one or more complex chronic conditions dependent on technologies. In our unit (Pediatric Pulmonology and Respiratory Intermediate Care Unit, Department of Pediatrics, "Bambino Gesù" Children's Hospital Research Institute), we regularly follow-up CMC patients, particularly children long-term, invasive (IMV) noninvasive (NIV), ventilation. suffering from diseases have lost the possibility to go hospital during COVID-19 pandemic. The aim this...
Abstract Rationale At‐home nocturnal pulse oximetry has a high positive predictive value (PPV) for polysomnographically‐diagnosed obstructive sleep apnea (OSA) but no studies have been published testing the night‐to‐night consistency of at‐home evaluation suspected OSA in children. We therefore determined as diagnostic test Methods prospectively studied 148 children (96 male) aged 4.9 ± 2.4 (1.2–11.8) years, referred OSA. To evaluate consistency, we compared an analysis method, McGill...
Structured Abstract Objectives To describe the prevalence of malocclusions in 2‐ to 10‐year‐old children suffering from obstructive sleep apnoea ( OSA ) and evaluate association between occlusal variables . Setting Sample Population A total 2101 consecutive patients referred an otorhinolaryngology unit were considered for study. One hundred fifty‐six (range 2‐10 years) with suspected selected a The final sample consisted 139 control group 137 children. Materials Methods All included study...
Abstract Background Children with chronic respiratory failure and/or sleep disordered breathing due to a broad range of diseases may require long-term ventilation be managed at home. Advances in the use non-invasive has progressively leaded reduction need for invasive mechanical through tracheostomy. In this study, we sought characterize cohort children using NIV and IMV perform an analysis those who showed significant changes ventilatory support management. Methods We performed...
Our aim was to assess the efficacy of noninvasive ventilation (NIV) for treatment thoracoabdominal asynchrony during sleep in children with spinal muscular atrophy (SMA) types 1 and 2.Nine subjects underwent assessment apnea/hypopnea index (AHI), mean oxyhemoglobin saturation (SpO2), oxygen desaturation index, transcutaneous carbon dioxide tension (tcpCO2), phase angle as a measure coordination. A second study performed use NIV.The nine patients (7 mos age, range 2-33) had baseline AHI 2.1...
Alterations in craniofacial growth have been associated with obstructive sleep apnoea children. The main objectives of this study were to analyse the correlation between cephalometric variables and Obstructive Apnea/Hypopnea Index (OAHI) order investigate if features may influence severity upper nasopharyngeal width maxillomandibular skeletal discrepancy sagittal vertical plane.Study Design: Correlations apnoea/hypopnea index airways space investigated. Forty-seven children diagnosed by...
Abstract Background During the pandemic, pneumology team at Bambino Gesù Children’s Hospital highlighted that telemedicine was a valuable tool for remotely managing medical needs of children with complexity (CMC). Following experience during emergency phase, service established, and new tools were tested to optimize televisits overall eHealth approach patients. In this context, TytoHome™ device performing objective examinations remotely. This pilot study, conducted our hospital, explored...
Our aim was to assess the respiratory pattern during sleep in patients affected by spinal muscular atrophy types 1 and 2 compare their apnea-hypopnea indices with those of controls.All consecutively referred underwent polysomnography. Sleep stages were defined as either wake, quiet (QS), or active (AS). As measures thoracoabdominal coordination, we measured: phase angle QS AS (Ph Angle AS), relation inspiration expiration AS: RIB QS, Ph AS, REB QS; AS) index.The 14 infants small children...
Abstract The aim of our study was to evaluate the efficacy adenotonsillectomy for treatment obstructive sleep apnea syndrome (OSA) in pediatric patients with Prader‐Willi (PWS), and describe postoperative complications. Five (4 males; median age, 4.4 years; range, 1.6–14.2 years) were studied. All underwent an overnight cardiorespiratory study. had adenotonsillar hypertrophy (ATH), two also obese. preoperative apnea/hypopnea index (AHI; range) 12.2 (9.0–19.9) events/hr; mean oxygen...
<i>Background/Aims:</i> Growth hormone (GH) is preferentially secreted during slow wave sleep and the interactions between human somatotropic system are well documented, although only few studies have investigated EEG in children with GH deficiency (GHD). The aim of this study was to evaluate structure dysregulation GH/insulin-like growth factor axis. <i>Methods:</i> Laboratory polysomnographic recordings were obtained from 10 GHD 20 normal healthy age-matched...
Long-term mechanical ventilation (LTV) with non-invasive (NIV) prolongs survival in patients Neuromuscular Diseases (NMDs). Transition from paediatric to adult healthcare system is an undervalued and challenging issue for children chronic conditions on ventilation.
Aim To identify subgroups regarding paediatricians' awareness, attitude, practice and satisfaction about management of Sleep-Disordered Breathing (SDB) in Italy using Latent Class Analysis (LCA). Methods A cross-sectional study was conducted on a large sample Italian paediatricians. Using self-administered questionnaire, the collected information 420 Paediatric Hospital Paediatricians (PHPs) 594 Family Care (FCPs). LCA used to discover underlying response patterns, thus allowing...
Questo caso clinico illustra il trattamento di un bambino affetto da apnee ostruttive nel sonno (OSA) che presenta una malocclusione classe II scheletrica retrusione mandibolare con contrazione del mascellare superiore e morso aperto anteriore. Il paziente grado moderato alto impatto sulla qualità della vita dei genitori. è stato trattato utilizzando dispositivo ortodontico innovativo (Sleep Apnea Twin Expander), al fine realizzare l'espansione palato l'avanzamento contemporaneamente. Dopo...