A5073131121- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Neuroscience and Neural Engineering
- Pharmacological Effects of Natural Compounds
- Galectins and Cancer Biology
- S100 Proteins and Annexins
- Aging, Health, and Disability
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Neurotoxicity Research
- Infrared Thermography in Medicine
- Signaling Pathways in Disease
- Stroke Rehabilitation and Recovery
- Immunotherapy and Immune Responses
- Cystic Fibrosis Research Advances
- Respiratory Support and Mechanisms
- Circular RNAs in diseases
- Spinal Dysraphism and Malformations
- Neonatal Respiratory Health Research
- Medical and Biological Ozone Research
- Polyomavirus and related diseases
- Graphene and Nanomaterials Applications
Hospital Nacional de Parapléjicos
2019-2025
Servicio de Salud de Castilla La Mancha
2015-2024
Universitat Autònoma de Barcelona
2024
Corporació Sanitària Parc Taulí
2024
Institute of Research and Innovation Parc Tauli
2024
University Hospital of Zurich
2020
Activation of astrocytes contributes to synaptic remodelling, tissue repair and neuronal survival following traumatic brain injury (TBI). The mechanisms by which these cells interact resident/infiltrated inflammatory rewire networks functions remain poorly understood. Here, we explored how TLR4-induced astrocyte activation modified synapses cerebrovascular integrity TBI.To determine functional alterations induced TLR4 pathway in regulate neurovascular after TBI, used pharmacology, genetic...
Cortical neuron-astrocyte communication in response to peripheral sensory stimulation occurs a topographic-, frequency-, and intensity-dependent manner. However, the contribution of this functional interaction processing inputs consequent behavior remains unclear. We investigate role astrocytes information at circuit behavioral levels by monitoring manipulating astrocytic activity vivo. show that control dynamic range cortical network activity, optimizing its responsiveness incoming inputs....
Studies on sensory information processing typically focus whisker-related tactile information, overlooking the question of how inputs from other body areas are processed at cortical levels. Here, we present a protocol for stimulating specific rodent limb receptive fields while recording in vivo somatosensory-evoked activity. We describe steps localizing cortical-hindlimb coordinates using acute peripheral stimulation, electrode placement, and application electrical stimulation. This...
Spinal cord injury (SCI) involves large-scale deafferentation of supraspinal structures in the somatosensory system, producing well-known long-term effects at thalamo-cortical level. We recently showed that SCI provokes immediate changes cortical spontaneous and evoked responses here, we have performed a similar study to define produced thalamic ventro-postero-lateral nucleus (VPL) are associated with forepaw hindpaw circuits. Extracellular electrophysiological recordings from VPL reflected...
During cortical development, plasticity reflects the dynamic equilibrium between increasing and decreasing functional connectivity subserved by synaptic sprouting pruning. After adult deafferentation, seems to be dominated increased connectivity, leading classical expansive reorganization from intact deafferented cortex. In contrast, here we show a striking "decrease" in fast responses high-intensity forepaw stimulation 1–3 months after complete thoracic spinal cord transection, as evident...
A randomized, double-blind, and placebo-controlled study was conducted to assess the effect of dietary supplementation with high-rich docosahexaenoic acid (DHA) (Tridocosahexanoin-AOX® 70%) at 50 mg/kg/day in pediatric patients cystic fibrosis (CF) as compared placebo. The duration 12 months. total 22 were included, 11 DHA group placebo group. mean age 11.7 years. outcome variables pulmonary function, exacerbations, sputum cellularity, inflammatory biomarkers peripheral blood, anthropometric...
The cortical reorganization after spinal cord injury (SCI) involves a series of physiological changes that drive the expansion intact area to deafferented area. These have always been studied under stimulus-response paradigm, which demonstrates cortex becomes more responsive stimulation body regions above level lesion. However, less is known about how permanent large-scale deafferentation affects spontaneous activity in somatosensory cortex, an important feature related processing peripheral...
Myelin, critical for the correct function of nervous system, is organized in different patterns that can include long non-myelinated axonal segments. How myelin patterning regulated remains unexplained. The carbohydrate-binding protein galectin-4 (Gal-4) influences oligodendrocyte differentiation vitro and associated with non-myelinable axon segments (NMS) cultured neurons. In consequence, Gal-4 has been proposed as a regulator, although no vivo studies have corroborated this hypothesis. We...
The complete or partial damage of ascending somatosensory pathways produced by a spinal cord injury triggers changes in the cortex consisting functional expansion activity from intact cortical regions towards deafferented ones, process known as reorganization. However, it is still unclear whether reorganization depends on severity if always leads to similar cortex. To answer these open questions field, we obtained longitudinal evoked responses bilateral hindlimb and forelimb animals with...
Cortical areas have the capacity of large-scale reorganization following sensory deafferentation. However, it remains unclear whether this phenomenon is a unique process that homogeneously affects entire deprived cortical region or susceptible to changes depending on neuronal networks across distinct layers. Here, we studied how local circuitry within each layer deafferented cortex forms basis for neuroplastic after immediate thoracic spinal cord injury (SCI) in anaesthetized rats. In vivo...
Abstract Intestinal infections trigger inflammation and can contribute to degenerative cognitive brain pathologies through the microbiota-gut-brain axis. Galectin-4 is an intestinal lectin key in control of pathogenic bacterial infections. Here we report that galectin-4 deficient mice (Lgals4-KO) show altered commensal microbiota absence pathogens, defining a new role modulation bacteria. Strikingly, Lgals4-KO present memory formation, impaired hippocampal long-term potentiation (LTP) vivo...
Abstract Background and purpose Activation of astrocytes contributes to synaptic remodeling, tissue repair neuronal survival following traumatic brain injury (TBI). However, the mechanisms by which these cells interact infiltrated inflammatory rewire networks functions remain poorly understood. Here, we explored how TLR4-induced astrocyte activation modified synapses cerebrovascular integrity TBI. Experimental approach We used pharmacological genetic approaches determine functional...
ABSTRACT Cortical areas have the capacity of large-scale reorganization following sensory deprivation. However, it remains unclear whether this phenomenon is a unique process that homogenously affects an entire deprived cortical region or suitable to changes depending on neuronal networks across distinct layers. Here, we studied how local circuitries within each layer cortex set basis for neuroplastic after immediate deprivation due thoracic spinal cord injury (SCI) in anaesthetised rats. In...
Cortical astrocytes respond to peripheral sensory stimulation in a topographic-, frequency- and intensity-dependent manner. However, whether astrocytic activity contributes the processing of information consequent behavior remains unclear. We have investigated role at circuit behavioral levels by monitoring manipulating vivo. show that control dynamic range cortical network activity, optimizing its responsiveness incoming inputs. The astrocytic-modulation set threshold for tactile thermal...