A5013412635- Leptospirosis research and findings
- Renal Transplantation Outcomes and Treatments
- Mosquito-borne diseases and control
- Malaria Research and Control
- Viral Infections and Vectors
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Cystic Fibrosis Research Advances
- Dengue and Mosquito Control Research
- Health Systems, Economic Evaluations, Quality of Life
- Bacterial Identification and Susceptibility Testing
- Carcinogens and Genotoxicity Assessment
- Meta-analysis and systematic reviews
- Pharmacological Effects and Toxicity Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Oral and gingival health research
- Statistical Methods in Clinical Trials
- DNA Repair Mechanisms
- Nosocomial Infections in ICU
- Biochemical and Molecular Research
- Insect-Plant Interactions and Control
- Transplantation: Methods and Outcomes
- Bacterial biofilms and quorum sensing
- Insect symbiosis and bacterial influences
- Liver Diseases and Immunity
Institut Pasteur de Nouvelle Calédonie
2017-2022
University of New Caledonia
2018
Takeda (France)
2004
Novartis (Switzerland)
2000
Hôpital Cochin
2000
Phase IV (United States)
1999
Ospedale Maggiore
1999
Novartis (France)
1997
Centre Hospitalier Universitaire de Clermont-Ferrand
1995
Hôpital Necker-Enfants Malades
1991-1993
Leptospirosis is an important environmental disease and a major threat to human health causing at least 1 million clinical infections annually. There has recently been growing interest in understanding the lifestyle of Leptospira. However, Leptospira isolation from complex samples difficult time-consuming few tools are available identify isolates species level. Here, we propose polyphasic identification scheme, which might prove useful recover select those be submitted whole-genome...
Despite recent advances in our understanding of the genomics members genus Leptospira , little is known on how virulence has emerged this heterogeneous bacterial as well lifestyle pathogenic outside animal hosts. Here, we isolated 12 novel species from tropical soils, significantly increasing number to 35 and finding evidence highly unexplored biodiversity genus. Extended comparative phylogenomics pan-genome analyses at level by incorporating 26 genomes, revealed that, traditional...
Leptospirosis is an important re-emerging infectious disease that affects humans worldwide. Infection occurs from indirect environment-mediated exposure to pathogenic leptospires through contaminated watered environments. The ability of persist in the aqueous environment a key factor transmission new hosts. Hence, effort was made detect complex environmental samples, genotype positive samples and assess leptospiral viability over time.We focused our study on human leptospirosis cases...
Background. Basiliximab is an interleukin-2 receptor (IL-2R; CD25) chimeric monoclonal antibody for immunoprophylaxis against acute rejection in renal transplantation. Its pharmacokinetics were characterized a multicenter open-label, prospective dose-escalation study to identify single-dose regimen providing IL-2R-saturating serum concentrations the critical first posttransplant month. Methods. Thirty-two recipients of primary, mismatched cadaver kidneys enrolled: 20 men and 12 women, who...
Polyethylene glycol (PEG)-modified bovine adenosine deaminase (ADA) is used for replacement therapy of severe combined immunodeficiency disease due to inherited ADA deficiency. We monitored IgG anti-ADA antibody in 17 patients treated by intramuscular injections PEG-ADA 1 greater than 5.5 yr. ELISA-detectable appeared 10 patients, usually between the third and eighth months treatment. Anti-ADA levels did not correlate with trough plasma activity, which averaged 1.8-5 times normal blood...
Abstract The zoonotic bacterium Leptospira interrogans is the aetiological agent of leptospirosis, a re-emerging infectious disease that growing public health concern. Most human cases leptospirosis result from environmental infection. Biofilm formation and its contribution to persistence virulent leptospires in environment or host have scarcely been addressed. Here, we examined spatial time-domain changes biofilm production by L. . Our observations showed highly dynamic process leads...
We analyzed an outbreak of gut colonization by Pseudomonas aeruginosa occurring in intensive care hematology unit using conventional typing methods and pulsed-field electrophoresis. In October November 1989, the feces four immunocompromised children undergoing total digestive decontamination were colonized P. aeruginosa. Ten isolates obtained from flora pure culture. Retrospective investigations found that one isolate stools patients was already present at high counts 6 months before...
Dengue virus (DENV) evolutionary dynamics are characterized by frequent DENV genotype/lineage replacements, potentially associated with changes in disease severity and human immunity. New Caledonia (NC) Cambodia, two contrasted epidemiological settings, respectively experienced a DENV-1 genotype IV to I replacement 2012 lineage 3–4 2005–2007, both followed massive dengue outbreak. However, their underlying drivers have not been elucidated. Here, we tested the hypothesis that these switches...
Dengue virus (DENV) is the arbovirus with highest incidence in New Caledonia and South Pacific region. In 2012–2014, a major DENV-1 outbreak occurred Caledonia. The only known vector of DENV Aedes aegypti but no study has yet evaluated competence Ae. populations to transmit DENV. This compared ability field-collected from different locations responsible for 2012–2014 outbreak. also aimed compare results French Polynesia as these two countries have close links, including circulation. Three...
Zika virus (ZIKV) has caused severe epidemics in South America beginning 2015, following its spread through the Pacific. We comparatively assessed vector competence of ten populations Aedes aegypti and Ae. albopictus from Brazil two one Culex quinquefasciatus New Caledonia to transmit three ZIKV isolates belonging African, Asian American lineages. Recently colonized mosquitoes eight distinct sites both countries were orally challenged with same viral load (107 TCID50/mL) examined after 7, 14...
Background Biological control programs involving Wolbachia -infected Aedes aegypti are currently deployed in different epidemiological settings. New Caledonia (NC) is an ideal location for the implementation and evaluation of such a strategy as only proven vector dengue virus (DENV) Ae . outbreaks frequency severity increasing. We report generation NC Wolbachia- infected strain results experiments to assess competence fitness this future disease Noumea, NC. Methods/principal findings The...
Background Estimates of leptospirosis morbidity identified Oceania as the region with highest burden. Besides Australia and New Zealand, is home Pacific Island Countries Territories, most which are developing countries facing a number challenges. Their archipelago geography notably affects health infrastructure access to healthcare. Although human was formerly in Vanuatu, there lack knowledge this disease country. We aimed identify outpatients visiting hospital. Methodology/Principal...
Dengue virus (DENV) serotype-2 was detected in the South Pacific region 2014 for first time 15 years. In 2016–2020, DENV-2 re-emerged French Polynesia, Vanuatu, Wallis and Futuna, New Caledonia, co-circulating with later replacing DENV-1. this context, epidemiological molecular evolution data are paramount to decipher diffusion route of region. current work, E gene from 23 serum samples collected Fiji, Caledonia sequenced. Both maximum likelihood Bayesian phylogenetic analyses were...
In spite of a local favorable environment, leptospirosis has never been described in Central African Republic so far mainly because the weakness diagnostic tests and differential strategy for febrile jaundice cases negative yellow fever virus. Here we bring complementary insight to conclusions Gadia CLB et al. regarding presence YFV-negative icteric patients.Our study included 497 individuals presenting with but infection, retrospectively selected from national surveillance biobank Institut...
The rare autosomal recessive Nijmegen breakage syndrome is characterised by severe immunodeficiency, microcephaly associated with mental retardation, and typical chromosomal rearrangements in peripheral T lymphocytes. This syndrome, though similar to ataxia telangiectasia, does not exhibit the neurological cutaneous signs of this disorder. We report here first patient ascertained France. Chromosome analysis detected, addition specific aberrations, two clonal cell proliferations which do...
Lawen, J.1; Davies, E.; Mourad, G.; Oppenheimer, F.; Gonzalez-Molina, M.; Bourbigot, B.; Durand, D.; Mulloy, L.; Wilkinson, A.; Girault, D. on behalf of the ‘Simulect International Study Group’. Author Information