A5020056339- interferon and immune responses
- Rabies epidemiology and control
- Influenza Virus Research Studies
- Poxvirus research and outbreaks
- Cell Image Analysis Techniques
- Autoimmune and Inflammatory Disorders
- Biomedical Ethics and Regulation
- Cutaneous Melanoma Detection and Management
- Heavy Metal Exposure and Toxicity
- Skin and Cellular Biology Research
- Virology and Viral Diseases
- Intramuscular injections and effects
- Spaceflight effects on biology
- Sarcoidosis and Beryllium Toxicity Research
- Aluminum toxicity and tolerance in plants and animals
- Healthcare Systems and Challenges
- Immune Cell Function and Interaction
- Trace Elements in Health
- Inflammatory Myopathies and Dermatomyositis
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Colorectal and Anal Carcinomas
- Polyomavirus and related diseases
- Hidradenitis Suppurativa and Treatments
- Circadian rhythm and melatonin
CDC Foundation
2024
Epidemic Intelligence Service
2024
University of Toronto
2022-2023
Dalhousie University
2019-2021
Children's Hospital of Philadelphia
2018
Glasgow Caledonian University
2003
Highlights•Influenza A virus PA-X targets the majority of host mRNAs for destruction•Downregulation by correlates with number splice sites in a transcript•Splicing renders RNAs susceptible to PA-X•The cellular CFIm complex interacts and contributes activitySummaryMany viruses shut off gene expression inhibit antiviral responses. Viral proteins required viral replication are typically spared this process, but mechanisms target selectivity during shutoff remain poorly understood. Using...
The hypotensive effect of exercise on intraocular pressure is well documented, however, little known about the pulsatile ocular blood flow. This study examines this and follows recovery flow after a standard period.Eighteen visually normal subjects participated in 4-min period bicycle ergometry. Intraocular were measured by pneumotonometry before, immediately exercise, at regular intervals during period.Intraocular was found to decrease significantly with strenuous recovered gradually toward...
Influenza A virus (IAV) increases the presentation of class I human leukocyte antigen (HLA) proteins that limit antiviral responses mediated by natural killer (NK) cells, but molecular mechanisms for these processes have not yet been fully elucidated. We observed infection with A/Fort Monmouth/1/1947(H1N1) IAV significantly increased HLA-B, -C, and -E on lung epithelial cells. Virus entry was sufficient to induce HLA upregulation because UV-inactivated had no effect. Aberrant internally...
Punctate palmoplantar keratoderma type 1 (PPPK1) presents in late childhood to adulthood with multiple small discrete hyperkeratotic papules on palms and soles. PPPK1 is an autosomal dominant skin disease caused by AAGAB mutations. It has been suggested that may be associated increased predisposition systemic malignancies.To evaluate the presence of mutations Canadian families possible malignancies.Eighteen unrelated were recruited for this study. Genomic DNA was extracted from saliva PCR...
Inadequate delivery of oxygen to organisms during development can lead cell dysfunction/death and life-long disabilities. Although the susceptibility developing cells low conditions changes with maturation, cellular molecular pathways that govern responses are incompletely understood. Here we show Caenorhabditis elegans substantially more sensitive anoxia than adult animals this sensitivity is controlled by nervous system generated hormones (e.g., neuropeptides). A screen neuropeptide genes...
The COVID-19 pandemic caused significant morbidity and mortality in people who inject drugs (PWID). Upper extremity soft tissue infections are frequently associated with intravenous drug use (IVDU) due to poor compliance aseptic technique. In Canada, multiple safe injection sites providing clean supplies closed, leaving many PWID no alternatives safely. It was hypothesized that these closures will correspond increased among PWID. main objective of this study determine the effect on incidence...
We represent a pediatric case of the congenital disorder caused by zinc malabsorption, acrodermatitis enteropathica, presenting with acute onsetof blisters. Although blisters can be seen in this condition, it is not always key feature and therefore overlooked when considering differential diagnosis blistering infancy. review common less features cutaneous eruption as well provide an extensive for also emphasize importance lifelong treatment supplementation these children.
Identifying the burden of disease related to plastic and reconstructive surgery in Canada will provide timely population-based data, inform policy, generate support for research funding.
On September 28, 2023, a kitten aged approximately 6 weeks found in Omaha, Nebraska, had test results positive for rabies at the Nebraska Veterinary Diagnostic Center (NVDC) after dying with neurologic signs and having bitten scratched its caretakers. Preliminary investigation identified 10 exposed persons whom postexposure prophylaxis (PEP)
Abstract Rabies is a fatal encephalitic disease affecting all mammals. This report describes identification of raccoon rabies virus variant isolated from stray kitten in an urban Midwestern city that nonendemic for this variant. The originally presented with nonspecific neurologic abnormalities. Astute veterinary, wildlife, and public health professionals played critical role the zoonotic extensive wildlife management response ensued. case serves as important reminder risk unvaccinated...
ABSTRACT Influenza A virus (IAV) increases presentation of class I human leukocyte antigen (HLA) proteins that limit antiviral responses mediated by natural killer (NK) cells, but molecular mechanisms have not yet been fully elucidated. We observed infection with A/Fort Monmouth/1/1947 (H1N1) IAV significantly increased HLA-B, -C and -E on lung epithelial cells. Virus entry was sufficient to induce HLA upregulation, because UV-inactivated had no effect. found upregulation elicited aberrant...
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