A5090106511- Research on Leishmaniasis Studies
- Archaeological and Geological Studies
- Archaeological and Historical Studies
- Trypanosoma species research and implications
- Microbial Community Ecology and Physiology
- Biocrusts and Microbial Ecology
- Eosinophilic Disorders and Syndromes
- Aquatic Ecosystems and Phytoplankton Dynamics
- Glutathione Transferases and Polymorphisms
- Archaeology and Cultural Heritage
- Medieval Architecture and Archaeology
- Mosquito-borne diseases and control
- Infectious Encephalopathies and Encephalitis
- Vector-borne infectious diseases
- Synthesis and Biological Evaluation
- Redox biology and oxidative stress
- Child Nutrition and Feeding Issues
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2020-2024
Universidade do Porto
2017-2023
University of Aveiro
2019
The freshwater cyanobacterium Phormidium sp. LEGE 05292 produces allelochemicals, including the cyclic depsipeptides portoamides, that influence growth of heterotrophic bacteria, cyanobacteria and eukaryotic algae. Using 16S rRNA gene amplicon metagenomics, we show here that, under laboratory conditions, mixture metabolites exuded by markedly reduces diversity a natural planktonic microbial community. Exposure same community to portoamides alone resulted in similar outcome. In both cases,...
Typical two-cysteine peroxiredoxins (2-Cys-PRXs) are H2O2-metabolizing enzymes whose activity relies on two cysteine residues. Protists of the family Trypanosomatidae invariably express one cytosolic 2-Cys-PRX (cPRX1). However, Leishmaniinae sub-family features an additional isoform (cPRX2), almost identical to cPRX1, except for lack elongated C-terminus with a Tyr-Phe (YF) motif. Previously, PRXs were considered vital components trypanosomatid antioxidant machinery. Here, we shed new light...
Leishmaniasis is one of the most neglected diseases in modern times, mainly affecting people from developing countries tropics, subtropics and Mediterranean basin, with approximately 350 million considered at risk this disease. The incidence human leishmaniasis has increased over past decades due to failing prevention therapeutic measures-there are no vaccines chemotherapy, which problematic. Acridine derivatives constitute an interesting group nitrogen-containing heterocyclic compounds...
Leishmania infantum (L. infantum) and major major) are phylogenetically related protozoan parasites that cause different pathologies in humans (visceral cutaneous infections, respectively). Here, we report on how these obligatory intracellular pathogens differentially affect the migration of macrophages. Resorting to gap closure assays infected murine bone marrow derived macrophages, observed L. enhances mobility cells. This is not case major, whose impact macrophage null. kinase inhibition...
Folate pathways components were demonstrated to be present in RNA-sequencing data obtained from uninfected and pathogen-infected Rhipicephalus ticks. Here, PCR qPCR allowed the identification of folate-related genes spp. ticks tick cell line IDE8. Genes coding for GTP cyclohydrolase I (gch-I), thymidylate synthase (ts) 6-pyrovoyltetrahydropterin (ptps) identified. Differential gene expression was evaluated by between infected samples four biological systems, showing significant upregulation...