A5086171043- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Oxidative Organic Chemistry Reactions
- Synthesis of Organic Compounds
- Ionic liquids properties and applications
- Chemical Reaction Mechanisms
- Synthesis and biological activity
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Reactions
- Synthesis and pharmacology of benzodiazepine derivatives
- Marine Sponges and Natural Products
- Trypanosoma species research and implications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Morinda citrifolia extract uses
- Traditional and Medicinal Uses of Annonaceae
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical synthesis and alkaloids
- Synthesis of heterocyclic compounds
- Asymmetric Synthesis and Catalysis
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Synthetic Organic Chemistry Methods
- Extraction and Separation Processes
Pontificia Universidad Católica de Chile
2016-2025
Institute of Inorganic Chemistry of the Slovak Academy of Sciences
2025
University of Chile
2011-2019
Rede de Química e Tecnologia
2014-2018
Universidad de Santiago de Chile
2014
Universidade de Santiago de Compostela
2010
University of Leicester
1998
University of California, Riverside
1988
Abstract A series of 4 (1H)-quinolones were obtained from Meldrum's acid and arylamines in two steps.
Solvation effects on the reaction mechanism for nucleophilic substitution reactions have been kinetically evaluated in conventional solvents and ionic liquids.
We report an experimental study on the effect of solvents model SN Ar reaction between 1-chloro-2,4-dinitrobenzene and morpholine in a series pure ionic liquids (IL). A significant catalytic is observed with reference to same run water, acetonitrile, other conventional solvents. The IL considered include anions, NTf2 (-) , DCN(-) SCN(-) CF3 SO3 PF6 FAP(-) cations 1-butyl-3-methyl-imidazolium ([BMIM](+) ), 1-ethyl-3-methyl-imidazolium ([EMIM](+) 1-butyl-2,3-dimethyl-imidazolium ([BM2 IM](+)...
A new an efficient synthesis of 2-aryl benzoxazoles and benzothiazoles by intramolecular cyclization 2-haloanilides/2-halothioanilides using a copper(<sc>i</sc>)-NHC complex is described.
In this work, the recovery of molybdenum(VI) (Mo) from aqueous solutions was carried out by solvent extraction (SX) using ammonium and phosphonium-based task-specific ionic liquids (TSILs) as extractants diluted in kerosene two other hydrophobic room-temperature (RTILs). Four different TSILs were used extractants: trioctylmethylammonium bis(2-ethylhexyl) phosphate [TOMA][D2EHP]; benzoate [TOMA][BA]; trihexyltetradecylphosphonium [P6,6,6,14][D2EHP]; [P6,6,6,14][BA]. These synthesized to...
Abstract Phenols and arylmethyl ethers are rapidly mononitrated by nitric acid adsorbed in silica gel at room temperature high yields.
We herein report results obtained from an integrated experimental and theoretical study on aromatic nucleophilic substitution (S(N)Ar) reactions of a series amines towards 1-fluoro-2,4-dinitrobenzene in water. Specific nucleophile-electrophile interactions the title have been kinetically evaluated. The whole undergoes S(N)Ar where formation Meisenheimer complex is rate determining. Theoretical studies concerning specific are discussed detail. It found that H-bonding effects along intrinsic...
A series of 2,6,9-trisubstituted purine derivatives have been synthesized and investigated for their potential role as antitumor agents. Twelve compounds were obtained by a three step synthetic procedure using microwave irradiation in pivotal step. All evaluated vitro to determine effect on cell toxicity the MTT method flow cytometry analysis four cancer cells lines Vero cells. Three out twelve found be promising agents compared known effective anticancer drug, etoposide, assayed with...
A set of new aryloxy-quinones were synthesized and evaluated<italic>in vitro</italic>against the epimastigote form of<italic>Trypanosoma cruzi</italic>and their unspecific cytotoxicity was tested on murine macrophages J-774 cells.
A cationic methallyl 2-pyridine-4,7-dimethoxybenzimidazole (L1) nickel precatalyst is highly selective in ethene dimerizations to 1-butene. The same catalyst isomerizes 1-butene and 1-octene internal olefins. Co-catalytic additives of B(C6F5)3 or BF3·OEt2 coordinate the increase reaction rates dimerization. ESI-MS was applied identifying a [L1NiH]+ cation as catalytically active species.
We designed, synthesized, and evaluated novel 2,6,9-trisubstituted purine derivatives for their prospective role as antitumor compounds. Using simple efficient methodologies, 31 compounds were obtained. tested these in vitro to draw conclusions about cell toxicity on seven cancer cells lines one non-neoplastic line. Structural requirements activity two different analyzed with SAR 3D-QSAR. The 3D-QSAR models showed that steric properties could better explain the cytotoxicity of than...
A series of ionic liquids (ILs) composed by choline (Ch) as a cation and different amino acids (AA) anions their respective aqueous mixtures were prepared using [Ch][AA] contents in range 0.4–46 mol % IL. These solvents used for the first time to achieve an eco-friendlier Paraoxon degradation. The results show that [Ch][AA]/water are effective reaction medium degrade Paraoxon, even when IL content mixture is low (0.4 IL) without need extra nucleophile. Both kinetics degradation pathways...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent effect studies on the thermal [1,5]-sigmatropic hydrogen shifts of vinylallenesGiin Yuan Shen, Ricardo Tapia, and William H. OkamuraCite this: J. Am. Chem. Soc. 1987, 109, 24, 7499–7506Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00258a041https://doi.org/10.1021/ja00258a041research-articleACS PublicationsRequest reuse...
Pyrogallol red (PGR) presents high reactivity toward reactive (radical and nonradical) species (RS). This property of PGR, together with its characteristic spectroscopic absorption in the visible region, has allowed developing methodologies aimed at evaluating antioxidant capacity foods, beverages, human fluids. These methods are based on evaluation consumption PGR induced by RS inhibition antioxidants. However, present, there no reports regarding degradation mechanism limiting extrapolation...