A5056937017- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Resilience and Mental Health
- Attention Deficit Hyperactivity Disorder
- Treatment of Major Depression
- Cognitive Abilities and Testing
- Neural dynamics and brain function
- Demographic Trends and Gender Preferences
- Child Abuse and Trauma
- Bipolar Disorder and Treatment
- Maternal Mental Health During Pregnancy and Postpartum
- Cardiac Arrest and Resuscitation
- Early Childhood Education and Development
- Transcranial Magnetic Stimulation Studies
- Behavioral Health and Interventions
- EEG and Brain-Computer Interfaces
- Grief, Bereavement, and Mental Health
- Posttraumatic Stress Disorder Research
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Migration, Health and Trauma
- Heart Rate Variability and Autonomic Control
Yale University
2021-2025
Stanford University
2019-2021
University of California, Los Angeles
2019
University of Vermont
2016
Abstract There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ enable stratification of patients with depression and anxiety. We used task-free task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in anxiety when treatment free ( n = 801) after randomization pharmacotherapy behavioral therapy 250). From these patients, we derived personalized interpretable scores...
BackgroundDespite tremendous advances in characterizing human neural circuits that govern emotional and cognitive functions impaired depression anxiety, we lack a circuit-based taxonomy for anxiety captures transdiagnostic heterogeneity informs clinical decision making.MethodsWe developed tested novel system quantifying 6 brain reproducibly at the individual patient level. We implemented standardized circuit definitions relative to healthy reference sample algorithms generate scores overall...
Through the Human Connectome Project (HCP) our understanding of functional connectome healthy brain has been dramatically accelerated. Given pressing public health need, we must increase how dysfunctions give rise to disordered mental states. Mental disorders arising from high levels negative emotion or loss positive emotional experience affect over 400 million people globally. Such states cut across multiple diagnostic categories mood and anxiety are compounded by accompanying disruptions...
Although the COVID-19 pandemic has been shown to worsen anxiety and depression symptoms, we do not understand which behavioral neural factors may mitigate this impact. To address gap, assessed whether adaptive maladaptive coping strategies affect symptom trajectory during pandemic. We also examined pre-pandemic integrity of brain regions implicated in symptoms. In a naturalistic sample 169 adults (66.9% female; age 19–74 years) spanning psychiatric diagnoses subclinical anhedonia, tension,...
Decision making requires consideration of both the benefits a given choice and costs, which can include risk, delay, effort. Previous research has examined developmental trajectory adolescent decision regarding risk delay; however, effects effort on remain largely unexplored. In present study, we pilot tested novel, developmentally-appropriate task designed to examine differences in willingness expend during goal pursuit adolescents (ages 13–16, n = 23) versus young adults 18–23, 25)....
Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse neuropsychiatric sequelae (APNS) is important targeting prevention interventions.
There is an imminent need to identify neural markers during preadolescence that are linked developing depression adolescence, especially among youth at elevated familial risk. However, longitudinal studies remain scarce and exhibit mixed findings. Here we aimed elucidate functional connectivity (FC) patterns preadolescents interact with risk predict two years later.
Background: Despite tremendous advances in characterizing human brain circuits that govern emotional and cognitive functions are impaired depression anxiety, we lack a circuitbased taxonomy captures transdiagnostic heterogeneity informs clinical decision making. Methods: We develop test novel system for quantifying six reproducibly at the individual patient level. implement standardized circuit definitions relative to healthy reference group, algorithms generate function dysfunction scores...
Background: Psychopathology demonstrates marked changes within and between individuals across development, especially during the transition from childhood to adolescence. Evidence characterizing directionality rate of change distinct dimensions psychopathology has been mixed, with different studies indicating increases, decreases, or no in internalizing externalizing symptoms. Moreover, much remains unknown about extent which trajectories differ individuals. Methods: Using a large, diverse...
The ongoing COVID-19 pandemic is a major stressor that has been associated with increased risk for psychiatric illness in the general population. Recent work highlighted experiences of early-life stress (ELS) may impact individuals' psychological functioning and vulnerability developing internalizing psychopathology response to pandemic-related stress. However, little known about neurobehavioral factors mediate association between ELS exposure COVID-related symptomatology. current study...
The COVID-19 pandemic is an ongoing stressor that has resulted in the exacerbation of mental health problems worldwide. However, longitudinal studies identify preexisting behavioral and neurobiological factors associated with outcomes during are lacking. Here, we examined associations between prepandemic coping strategy engagement frontolimbic circuitry internalizing symptoms pandemic. In 85 adults (71.8% female; age 18-30 years), assessed prototypically adaptive strategies (Connor-Davidson...