Objective. To study the dynamics of changes in indicators biochemical blood analysis and markers state hemostasis fibrinolysis systems patients with previously treated bronchial asthma (BA) moderate severity who had did not have COVID-19 before during treatment. Material methods. The included 58 were divided into two groups: 1st (BA/COVID-19; n=29) – BA undergone COVID-19; 2st (BA; COVID-19. Markers impaired liver function, lipid metabolism, as well a marker systemic inflammation, C-reactive...

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Pulmonary tuberculosis and malignant neoplasms (MNs) are important global healthcare issues. There has been a large number of studies on the relationship between pulmonary MNs, but comprehensive approaches to diagnosis treatment these diseases need be developed implemented. Objective. To study at current stage phthisiology. Materials methods. Analysis domestic foreign databases for period from 1976 2024 was performed. The following keywords were used search literature: «tuberculosis»,...

The objective : to compare changes in markers of hemostasis and fibrinolysis during the course treatment new patients with pulmonary tuberculosis (TB), who suffered from COVID-19 no COVID-19. Subjects Methods . 50 were enrolled a retrospective study, them 25 had history (TB/COVID-19 Group) (TB Group). state was assessed at four checkpoints: admission hospital for after 1, 2, 3 months treatment. To assess relationship between detected systemic inflammation, C-reactive protein (CRP)...

The main indications for the use of surgical treatment methods are destructive forms tuberculosis process with drug resistance pathogen, including bilateral ones. However, resection may be accompanied by a large amount loss lung tissue and violation functional parameters lungs in future. A possible solution to this problem can collapse therapy (artificial pneumoperitoneum) valvular bronchoblocation as preoperative preparation patients pulmonary tuberculosis, those pathogen. clinical case is...

Currently, according to the World Health Organization, targets for effectiveness of treatment patients with pulmonary tuberculosis do not achieve their goals. In this regard, it is urgent search optimal integrated approaches in tuberculosis. The aim work demonstrate high use methods collapse therapy and CBB complex a patient widespread process. Materials . analysis patient’s medical documentation was carried out, data anamnesis disease, X-ray archive, clinical, laboratory instrumental...

216 new pulmonary tuberculosis patients suffering from multiple drug resistance (MDR) were examined. The divided into 2 groups. first group consisted of 164 in whom when admitted to hospital, GeneXpert MTB/RIF was used test the Mycobacterium (MTB) rifampicin. Initially, this treated with chemotherapy regimen 4 (pyrazinamide, kanamycin/amikacin/capreomycin, fluoroquinolones, cycloserine/terizidone, prothionamide, PAS). Group included 97 patients. They all 1 (isoniazid, rifampicin,...

The level of uric acid in blood serum was investigated 134 new patients suffering from multiple drug resistant pulmonary tuberculosis (78 men and 56 women). tests were performed by admission to hospital then repeated 1, 2, 3, 4, 5, 6, 7 8 months treatment. Prior chemotherapy the increased observed 28.2% 37.5% women. During treatment with pyrazinamide this category 1 month after start further it went down; however above normal during whole course Monitoring initially rates has shown that...

This review provides new literature data on the features of changes in indicators clinical and biochemical analysis blood, as well hemostatic fib-rinolysis systems patients with coronavirus infection COVID-19. It was shown that laboratory manifestations COVID-19 have their own characteristics are closely interrelated nature course infection. In a blood test, lymphopenia thrombocytopenia most common. Among bio-chemical parameters an increase level C-reactive protein ferritin, decrease...

238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). CD4 count in the examined 0 1.216 × 10 9 /L. intensity systematic inflammatory response was evaluated as per rates acute phase reactants: С-reactive protein (СRP), α 1 -antitrypsin (α -АТ), haptoglobin (HG) fibrinogen (F). It found out that demonstrated confidently increased levels C-reactive protein, -antitrypsin, haptoglobin,...

The objective: to study the quantity and variability of bacterial microbiota in lower gut, prevalence microorganisms resistant antibacterial drugs among isolated from bronchi pulmonary tuberculosis patients receiving chemotherapy. Subjects methods . Microorganisms gastrointestinal tract respiratory were studied. 178 examined retrospectively 53 prospectively. Diagnostic specimens obtained bronch i/l ungs (sputum, bronchoalveolar lavage fluid, aspirate, etc.) tested. Bacteriological tests...

45 pulmonary tuberculosis patients with concurrent type 1 diabetes, 69 2 diabetes and 131 without (control group) were examined. The intensity of the system inflammatory response syndrome was evaluated by markers acute inflammation phase – blood levels C-reactive protein (CRP), serum amyloid A (SAA), α1 -antitrypsin (α1 -АТ), haptoglobin, fibrinogen. Nutritional status assessed body mass index (BMI) concentration total (TP), albumin (A), transthyretin (TTR). It found out that in new...

Ретроспективный анализ особенностей течения туберкулеза у пациентов (n=830), умерших от прогрессирования специфического процесса, показал, что туберкулез часто сочетался с сахарным диабетом (n=102), и ВИЧ-инфекцией

The objective : assessment of changes in the parameters complete blood count, clinical urine tests, and chemistry during chemotherapy patients with MDR/XDR pulmonary tuberculosis receiving short-course regimen containing bedaquiline, pretomanid, linezolid (B-Pa-L). Subjects Methods . 18 MDR/pre-XDR/XDR were enrolled into study. They all received treatment at Central Tuberculosis Research Institute from 2015 to 2022. Results In course these patients, laboratory test results noted different...

The review provides literature data on the use of physiotherapy methods in complex treatment pulmonary TB patients along with chemotherapy. combination enables to increase effectiveness by more rapid achievement sputum conversion and cavity closure and, thus, shorten inpatient phase treatment. Positive effects are achieved due anti-inflammatory, desensitizing, bronchodilator, immunecorrective other actions physical factors used phthisiology

Introduction. It is known that both tuberculosis patients and COVID-19 develop a systemic inflammatory response with changes in the indicators of acute phase reactants, clinical blood analysis hemostasis fibrinolysis system. Aim. To study comparative aspect, level counts markers state systems newly diagnosed pulmonary who had did not have an infection caused by SARS-CoV-2. Material Methods. A retrospective was conducted 60 SARS-CoV-2: 30 mild severity moderate severe severity. The comparison...

The objective: to develop approaches selection of optimal chemotherapy regimens in tuberculosis patients with concurrent diabetes mellitus (DM), by studying complications and adverse drug reactions anti-tuberculosis drugs. Subjects Methods. 235 adult pulmonary were enrolled the study. Of them, 123 men (52.3%) 112 women (47.7%), age varied from 19 78 years old. Results. Complications (DM) reported 190/235 (80.8%) patients. Encephalopathy occurred most often – 147/190 (77.3%) patients,...

In the Russian Federation, there is an increase in patients with pulmonary tuberculosis combination comorbid pathologies, including Crohn's disease. There also a tendency to of and non-tuberculosis mycobacteriosis, which makes it difficult select adequate therapy reduces effectiveness treatment. Bronchial one complications process often masks onset this connection, diagnosis bronchi difficult. A young patient history disease was diagnosed bronchial mycobacteriosis. Upon admission, presence...

One of the complications tuberculosis process is tracheobronchial tree, which tends to grow in recent years. Many studies indicate incidence bronchial from 10% 40%, taking into account level diagnostic measures detect and availability endoscopic services. An important problem treatment psychological problems patients, including those with drug-resistant tuberculosis. In phthisiology, attention drawn widespread history stress patients complexity rehabilitation against background treatment....

Objective. To study in a comparative aspect the level of markers state hemostasis and fibrinolysis systems, indicators clinical blood analysis C-reactive protein (CRP) patients with chronic obstructive pulmonary disease (COPD) severe extremely severity, who underwent did not undergo infection caused by SARS-CoV-2. Material methods. A prospective cohort 56 COPD acute stage. Patients were divided into 2 groups: 1st (n=28) – SARS-CoV-2 infection; 2nd without infection. The CRP evaluated....

Background . Despite the visible successes of domestic phthisiology at present time, problem medical rehabilitation patients with tuberculosis remains relevant. In recent years, approaches to various diseases have changed significantly, which entail need consider a complex measures for from perspective Procedures organizing in adults and children their integration into phthisiatric practice. The aim To study organizational aspects respiratory world Russian Federation. Methods We carried out...