A5013235525- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Nosocomial Infections in ICU
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Infection Control in Healthcare
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Surgical site infection prevention
- Urinary Tract Infections Management
- Fungal Infections and Studies
- Vibrio bacteria research studies
- Pneumonia and Respiratory Infections
- Infections and bacterial resistance
- Neonatal and Maternal Infections
- Emergency and Acute Care Studies
- Bacterial biofilms and quorum sensing
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 detection and testing
- Research on Leishmaniasis Studies
- COVID-19 diagnosis using AI
All India Institute of Medical Sciences
2016-2025
University of Birmingham
2024-2025
All India Institute of Medical Sciences Raipur
2015-2024
All India Institute of Medical Sciences Bhopal
2015-2024
Lok Nayak Jai Prakash Narayan Hospital
2012-2024
Indian Spinal Injuries Centre
2023
Creative Commons
2023
P. D. Hinduja Hospital and Medical Research Centre
2021
National Institute of Medical Statistics
2020
Port Moresby General Hospital
2019
Critically ill coronavirus disease 2019 (COVID-19) patients need hospitalization which increases their risk of acquiring secondary bacterial and fungal infections. The practice empiric antimicrobial prescription, due to limited diagnostic capabilities many hospitals, has the potential escalate an already worrisome resistance (AMR) situation in India. This study reports prevalence profiles infections (SIs) clinical outcomes hospitalized COVID-19 India.A retrospective admitted intensive care...
Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung hypothesised to correlate with an increased risk infection complications COrona VIrus Disease 2019 (COVID-19). To test this hypothesis, we compared status immunohistochemistry (IHC) post-mortem samples patients who died COVID-19 obtained from non-COVID-19 for other indications....
Background There is a paucity of data on the epidemiology sepsis in outborn neonates being referred to level-3 units low- and middle-income countries (LMIC). The objective present study was evaluate prevalence outcomes with sepsis, characterize pathogen profile antimicrobial resistance (AMR) patterns common isolates them. Methods In this prospective observational cohort (2011–2015), dedicated research team enrolled all admitted an neonatal unit followed them until discharge/death. Sepsis...
BackgroundHealth-care-associated infections (HAIs) cause significant morbidity and mortality globally, including in low-income middle-income countries (LMICs). Networks of hospitals implementing standardised HAI surveillance can provide valuable data on burden, identify monitor prevention gaps. Hospitals many LMICs use case definitions developed for higher-resourced settings, which require human resources laboratory imaging tests that are often not available.MethodsA network 26...
Candidaemia is a potentially fatal infection with varied distribution of Candida species and their antifungal susceptibility profiles. The recent emergence auris in invasive candidiasis cause for concern. This study describes the profile candidaemia at an Indian tertiary care hospital reports C. auris. All patients diagnosed between 2012 2017 were studied. isolates identified using conventional methods, VITEK 2 MALDI-TOF MS. not by sequenced. Antifungal testing was done CLSI broth...
The emergence of fluconazole resistance in Candida parapsilosis healthcare-associated infections has recently been increasingly reported. Antifungal susceptibility profiles and mechanisms C. (n = 199) from nine hospitals India collected over a period 3 years were studied. Further, clonal transmission fluconazole-resistant isolates different was investigated.Antifungal testing five azoles, amphotericin B 5-flucytosine performed by the CLSI microbroth dilution method. azole target ERG11 gene...
OBJECTIVE To report the International Nosocomial Infection Control Consortium surveillance data from 40 hospitals (20 cities) in India 2004–2013. METHODS Surveillance using US National Healthcare Safety Network’s criteria and definitions, methodology. RESULTS We collected 236,700 ICU patients for 970,713 bed-days Pooled device-associated healthcare-associated infection rates adult pediatric ICUs were 5.1 central line–associated bloodstream infections (CLABSIs)/1,000 line–days, 9.4 cases of...
Recently, in India, there has been a shift from NDM to OXA48-like carbapenemases. OXA-181 and OXA-232 are the frequently produced variants of carbapenemases also known be carried on transposons such as Tn1999, Tn1999.2 it is associated with IS1R Tn1999. In no previous reports studying association mobile genetic elements (MGEs) The present study was aimed at determining backbone determine role MGEs its transfer investigate Inc plasmid type carrying blaOXA48-like.A total 49 carbapenem...
Background The incidence of hypervirulent (hv) carbapenem-resistant (CR) Klebsiella pneumoniae (Kp) is increasing globally among various clones and also responsible for nosocomial infections. CR-hvKp formed by the uptake a virulence plasmid endemic high-risk or plasmids carrying antimicrobial resistance genes virulent clones. Here, we describe from India belonging to that have acquired are phenotypically unidentified due lack hypermucoviscosity. Methods Twenty-seven CRKp isolates were...
The widespread resistance in Gram-negative bacteria has necessitated evaluation of the use older antimicrobials such as polymyxins. In present study we evaluated different susceptibility testing methods for polymyxins B and E against using new Clinical Laboratory Standards Institute (CLSI) guidelines.The 281 multidrug-resistant (MDR) (GNB) to polymyxin was evaluated, comparing broth microdilution (BMD; reference method), agar dilution, E-test, disk diffusion. Disk diffusion also performed...
ABSTRACT AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of many Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, β-lactamase inhibitor/β-lactam combinations. The increase in antibiotic among Gram-negative bacteria is notable example how can procure, maintain express new genetic information that confer one or several antibiotics. Detection organisms producing these...
Establishing and expanding government led networks to strengthen infection prevention control healthcare associated surveillance are essential effectively tackle antimicrobial resistance. <b>Soumya Swaminathan colleagues</b> discuss the progress in India
ABSTRACT Background: Urinary tract infections (UTIs) remain a major problem both in hospitalized and outdoor patients. Multidrug-resistant enterococci are emerging as nosocomial pathogen with increasing frequency. However, the incidence of community-acquired enterococcal species prevalent India is not thoroughly investigated. Objectives: This study aims to estimate burden UTIs seen at tertiary care hospital identify Enterococcus isolated from these The also determine antibiotic...
Acinetobacter baumannii is an opportunistic pathogen responsible for causing nosocomial infections. A. develops resistance to various antimicrobial agents including carbapenems, thereby complicating the treatment. This study was performed characterize isolates presence of β-lactamases encoding genes and type compare our clones with existing international across five centres in India.A total 75 non-repetitive clinical from different were included this study. All confirmed as by bl...
Purpose. Resistant Gram-negative bacterial (GNB) infections, apart from tremendously escalating the cost of treatment, are a cause for substantial morbidity and mortality among hospitalized patients. Such bacteria rapidly acquiring resistance to many antimicrobial agents, especially beta-lactams which most frequently prescribed antimicrobials in hospital community patient care settings, now also colistin; last-line drug treat infections with such bacteria. The greatest threat treatment is...
Plasmid has led to increase in resistant bacterial pathogens through the exchange of antimicrobial resistance (AMR) genetic determinants horizontal gene transfer. Baseline data on occurrence plasmids carrying AMR genes are lacking India. This study was aimed identify associated with ESKAPE pathogens.A total 112 isolates including Escherichia coli (n=37), Klebsiella pneumoniae (n=48, 7 pan-drug susceptible isolates), Acinetobacter baumannii (n=8), Pseudomonas aeruginosa (n=1) and...