A5086948253- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Geology and Paleoclimatology Research
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Geological and Geophysical Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Marine and environmental studies
- Geological formations and processes
- Plant Virus Research Studies
- Flood Risk Assessment and Management
- Climate variability and models
- Fungal Biology and Applications
- Antimicrobial Resistance in Staphylococcus
- Plant-Microbe Interactions and Immunity
- Methane Hydrates and Related Phenomena
- Groundwater and Watershed Analysis
- Cryospheric studies and observations
- Bacterial Identification and Susceptibility Testing
- Yeasts and Rust Fungi Studies
- Hydrology and Drought Analysis
- Fisheries and Aquaculture Studies
- Obesity, Physical Activity, Diet
- Groundwater flow and contamination studies
- Electrochemical Analysis and Applications
Lovely Professional University
2025
University of Delhi
2015-2024
Indian Council of Medical Research
2024
ICMR National Institute for Research in Environmental Health
2024
National Remote Sensing Centre
2021
Centre of Advanced Studies
2021
Post Graduate Institute of Medical Education and Research
2018
University of Tübingen
2009-2013
Lala Lajpat Rai Memorial Medical College
2012
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2012
Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. We studied the antifungal susceptibility of C. isolates (n = 350) from 10 hospitals India collected over a period 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations FKS1 analysed. CLSI testing six azoles, amphotericin B, three echinocandins, terbinafine, 5-flucytosine nystatin Screening for amino acid...
In New Delhi, India, candidemia affected 15 critically ill coronavirus disease patients admitted to an intensive care unit during April-July 2020. Candida auris accounted for two thirds of cases; case-fatality rate was high (60%). Hospital-acquired C. infections in may lead adverse outcomes and additional strain on healthcare resources.
Summary In the last few years, infections caused by dermatophytes along with a concomitant increase in number of difficult to treat cases have increasingly been recognised, indicating that dermatophytosis remains challenging public health problem. The majority are Trichophyton rubrum and mentagrophytes complex. Terbinafine, an allylamine antifungal used orally topically is considered be first‐line drug therapy dermatophyte infections. Terbinafine resistance has predominately attributed point...
Candida auris is a multidrug resistant pathogen that presents serious global threat to human health. As C. newly emerged pathogen, several questions regarding its ecological niche remain unexplored. While species closely related have been detected in different environmental habitats, little known about the natural habitat(s) of Here, we explored virgin habitats around very isolated Andaman Islands Indian Ocean for evidence We sampled coastal wetlands, including rocky shores, sandy beaches,...
Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia. Elevated azole MICs detected Saccharomyces cerevisiae upon heterologous expression C. aurisERG11 alleles that encoded for Y132F or K143R substitutions; however, encoding I466M, Y501H, other clade-defined differences yielded susceptible MICs. Similar to species, specific mutations resulted directly reduced susceptibility.
Candida auris is a nosocomial pathogen responsible for an expanding global public health threat. This ascomycete yeast has been frequently isolated from hospital environments, representing significant reservoir transmission in healthcare settings. Here, we investigated the relationships among C. isolates patients with chronic respiratory diseases admitted chest and their fomites, using whole-genome sequencing (WGS) multilocus microsatellite genotyping. Overall, 37.5% (n = 12/32) developed...
During the past decade, a prolonged and serious outbreak of dermatophytosis due to terbinafine-resistant novel species in Trichophyton mentagrophytes - T. interdigitale complex has been ongoing India, it spread several European countries. The objective this study was investigate molecular background squalene epoxidase ( SQLE ) gene order understand risk emergence multiresistance dermatophytes.
The ongoing pandemic of coronavirus disease 2019 (COVID-19) has overwhelmed healthcare facilities and raises an important novel concern nosocomial transmission Candida species in the intensive care units (ICUs).We evaluated incidence risk factors for development candidemia 2384 COVID-19 patients admitted during August 2020-January 2021 ICUs 2 hospitals (Delhi Jaipur) India. A 1:2 case-control matching was used to identify who did not develop as controls.A total 33 developed accounted overall...
Superficial fungal infections of the skin, hair, and nails are fourth most common cause human disease affecting 20% to 25% world's population [1].Dermatophytosis is a superficial infection caused by dermatophytic fungi that affect skin keratinized structures (hair nails) arising from it.Dermatophytes, especially genera Trichophyton, majority mycoses.These result in considerable morbidity economic burden on healthcare system [2].In recent years, an alarming increase frequency recalcitrant...
Candida auris is a multidrug-resistant nosocomial fungal pathogen. While the marine environment was recently identified as natural niche for C. auris, environment(s) that might have contributed to development and spread of antifungal resistance in remains mystery. Because stored fruits are often treated with fungicides prevent postharvest spoilage, we hypothesized could serve possible selective force transmission reservoir antifungal-resistant isolates pathogenic yeasts, including auris. To...
We present a geochemical and Sr-Nd isotopic study on sediment core collected from the Andaman Sea in an attempt to reconstruct Late Quaternary weathering erosion patterns watersheds of river systems Myanmar understand their controlling factors. Age control is based nine radiocarbon dates δ18O stratigraphy. The rate sedimentation was strongly controlled by fluctuations monsoon. identify three major provenances: (1) Irrawaddy catchment, (2) western slopes Indo-Burman-Arakan (IBA) mountain...
The emergence of fluconazole resistance in Candida parapsilosis healthcare-associated infections has recently been increasingly reported. Antifungal susceptibility profiles and mechanisms C. (n = 199) from nine hospitals India collected over a period 3 years were studied. Further, clonal transmission fluconazole-resistant isolates different was investigated.Antifungal testing five azoles, amphotericin B 5-flucytosine performed by the CLSI microbroth dilution method. azole target ERG11 gene...
Candida glabrata infections are increasing worldwide and exhibit greater rates of antifungal resistance than those with other species. DNA mismatch repair (MMR) gene deletions, such as msh2Δ, in C. resulting a mutator phenotype have recently been reported to facilitate rapid acquisition resistance. This study determined the susceptibility profiles 210 isolates 10 hospitals India investigated impact novel MSH2 polymorphisms on mutation potential. No echinocandin- or azole-resistant strains no...
Abstract Understanding the factors that control variability of oxygen isotopic ratios (δ 18 O) Indian Summer Monsoon (ISM) rainfall O p ) is vital importance for interpretation δ derived from climate proxies (e.g., speleothem and tree ring cellulose) this region. Here we demonstrate moisture transport pathways on spatiotemporal variations ISM using a new set daily observations central northern India previously reported data aided by simulations an isotope‐enabled General Circulation Model....
Melanized or black fungi are a heterogeneous group of causing cutaneous to systemic diseases with high mortality. These rarely reported as agents human infections, primarily due difficulties in their classical identification. In this study, we examined, using molecular methods and matrix-assisted laser desorption ioniazation-time flight mass spectrometry (MALDI-TOF MS), the diversity melanized (MF) isolated from patients 19 medical centers India. Overall, during 4-year period, 718 (5.3%)...
is an emerging multidrug-resistant human fungal pathogen refractory to treatment by several classes of antifungal drugs. Unlike other
Abstract Background Treatment‐resistant dermatophytosis caused by Trichophyton mentagrophytes / interdigitale complex has emerged as a global public health threat, particularly in endemic countries like India and spread to many other countries. This veritable is alarming due increase resistance terbinafine, which targets the ergosterol biosynthetic pathway inhibiting enzyme squalene epoxidase (SQLE). About two third of studies worldwide have reported amino acid substitutions Phe397Leu...
Aspergillosis due to azole-resistant Aspergillus fumigatus is a worldwide problem with major therapeutic implications. In patients invasive aspergillosis, low yield of fungal cultures results in underestimation azole resistance. To detect resistance A. fumigatus, we applied the AsperGenius® Resistance multiplex real-time polymerase chain reaction (PCR) assay TR34/L98H, and TR46/T289A/Y121F mutations G54/M220 RUO PCR directly bronchoalveolar lavage (BAL) samples 160 chronic respiratory...
Olorofim is a novel antifungal agent with in vitro activity against Aspergillus and other opportunistic moulds. We investigated the of olorofim range filamentous fungi comprising isolates species, Scedosporium Alternaria alternata, dermatophytes, including terbinafine- multidrug-resistant Trichophyton Penicillium/Talaromyces species originating from patients North India.Antifungal susceptibility was tested 241 mould A. fumigatus cryptic alternata using CLSI broth microdilution. The...