A5079351183- Pharmacological Effects and Toxicity Studies
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neurological disorders and treatments
- RNA regulation and disease
- Epilepsy research and treatment
- Genomics and Rare Diseases
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Immunology Research
- Intensive Care Unit Cognitive Disorders
- Infant Development and Preterm Care
- Anesthesia and Neurotoxicity Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism and Genetic Disorders
- Family and Patient Care in Intensive Care Units
- Language Development and Disorders
- Trace Elements in Health
- Hereditary Neurological Disorders
- Traumatic Brain Injury Research
- Genetics and Neurodevelopmental Disorders
- Acute Lymphoblastic Leukemia research
- Cerebral Palsy and Movement Disorders
- Molecular Biology Techniques and Applications
- Mitochondrial Function and Pathology
- Children's Physical and Motor Development
Ain Shams University
2017-2024
Ain Shams University Hospital
2020-2022
Abstract Heterozygous mutations in KMT2B are associated with an early-onset, progressive and often complex dystonia (DYT28). Key characteristics of typical disease include focal motor features at presentation, evolving through a caudocranial pattern into generalized dystonia, prominent oromandibular, laryngeal cervical involvement. Although KMT2B-related is emerging as one the most common causes early-onset genetic much remains to be understood about full spectrum disease. We describe cohort...
ABSTRACTBackground Harel-Yoon syndrome (HAYOS) is a recently described neurodevelopmental disorder characterized by psychomotor delay, truncal hypotonia, appendicular spasticity, and peripheral neuropathy. It caused mutations in ATAD3A gene located on chromosome 1p.36.33 whose functions include mitochondrial DNA stabilization, the regulation of fission/fusion, cholesterol homeostasis.Materials Methods An 11-year-old male patient consanguineous Egyptian parents, who present with...
Background Vitamin D has recently gained increased attention owing to its immunomodulatory role. Epidemiological evidence demonstrates that deficiency of is a relevant risk for acute acquired immune-mediated inflammatory demyelinating diseases in childhood, such as Multiple sclerosis (MS). Exact mechanism remains widely unexplored. Aim measure the serum level vitamin D-25(OH) pediatric patients diagnosed with central and peripheral diseases, compare these levels found healthy age gender...
Abstract Background Myelitis may be the first presentation of relapsing acquired demyelinating syndromes (ADS) such as neuromyelitis optica (NMO) or multiple sclerosis (MS) and in association with connective tissue diseases. It also occur context acute disseminated encephalomyelitis (ADEM). Early recognition myelitis these disorders will allow better management plan including theprognosis. Objective To evaluate frequency among children neurological diseases, variability clinical features,...
Abstract Background Several case reports and studies have described an association between sleep epileptiform discharges language dysfunctions. This has been partly confirmed in that investigated the effect of this on neurocognitive function. Objectives To screen for sleep-potentiated children with dysfunction (language delay or regression) to evaluate treatment these dysfunction. Methods The study was conducted 93 regression. Patients were recruited from pediatric neurology clinic,...
Abstract Background In epilepsy patients, the pandemic has led to postponement of outpatient visits, cancellation epilepsy-related tests, such as electroencephalograms (EEG) and magnetic resonance imaging (MRI) studies, even difficulties in attending emergency situations due saturation healthcare services, which can create life threatening for patients who present rooms with non-COVID related complaints. Aim Work To evaluate effect COVID-19 on supplying anti-epileptic medications children...
Abstract Background In children, cerebrovascular events are classified into acute ischemic or hemorrhagic stroke. Ischemic stroke includes both arterial (AIS) and cerebral sino-venous thrombosis (CSVT). Compared to adults, pediatric have a heterogeneous etiology various clinical presentations. Both factors lead delay in diagnosis proper management. Aim Our aim is study risk for the occurrence of children. Patients Methods A retrospective medical record review all children admitted Children's...
Abstract Background Advances in paediatric critical care have resulted a reduction mortality. This has shifted the focus to intensive unit (PICU)-related morbidities and how reduce or prevent them. In this study, we aimed study impact of (PICU) admission on neurocognitive performance. Methods Intelligence quotient (IQ) was tested 50 children (27 boys, 23 girls; mean age 6.98 years) 3 months after PICU discharge 75 controls using Stanford-Binet IQ test. Results There no statistically...
Abstract A 4-year-old boy presented to the emergency room with severe abdominal pain, tachypnea and vomiting followed by progressive obtundation. He was found have hyperglycemia, ketonuria metabolic acidosis. diagnosis of Diabetic ketoacidosis hence made managed as such, improvement in his laboratory parameters well level consciousness. On day 6 after admission, developed a recurrence altered consciousness repeated seizures. examination had spastic quadriparesis lateralizing right side. MRI...
Background The chemokine, C-X-C motif ligand 13 (CXCL13) plays an important role in B cell recruitment within the central nervous system (CNS). CXCL13 has been implicated as key regulatory factor inflammatory CNS disorders including autoimmune diseases. Aim of Work To compare between serum level patients diagnosed with acute or peripheral demyelination and healthy age gender matched controls. Patients Methods Twenty (patients’ group) demyelinating diseases (acute disseminated...
Abstract Chronic Traumatic Encephalopathy (CTE), Syndrome (TES), and Post-Concussion (PCS) are increasingly recognized as significant consequences of repetitive head trauma, spanning both contact sports nonsports-related injuries. This article presents a compelling case study patient afflicted by these conditions, elucidates the differential diagnosis, explores therapeutic promise new protocols Hyperbaric Oxygen Therapy (HBOT). Our centers on ‘FC,’ 36-year-old former captain English rugby...
Abstract Objective to assess the short-term prognostic aid of initial Electroencephalography (EEG) in patients with acute viral encephalitis. Methods An observational follow up study including 30 children non-herpetic Cases were subjected full history taking, examination and an EEG recording obtained during hospital admission. Functional outcome assessment was done using Liverpool score admission repeated again at 3 months post discharge. Results The mean age 2.8 ±3.5 years old, ages ranging...
Abstract Objective To study the impact of admission to a pediatric intensive care unit (PICU) on children's neurocognitive performance. Methods A case–control observational including 50 children & adolescents and 75 age gender matched adolescents.The subjects underwent formative IQ testing using Stanford Binet test 3 months after discharge from PICU. Results 27 males 23 females with mean 6.98 years were included in study. Almost two thirds cases admitted PICU post operatively (surgical...
Abstract Objective To assess the clinical and neuroimaging findings of pediatric patients with drug-resistant focal epilepsy, comparing conventional MR technique to "essential 6” protocol. Methods An observational study 18 children drug resistant seizures identified both clinically and/or by EEG findings. Available data as well MRI in patients’ files at neurology clinic Ain Shams University was retrospectively evaluated documented. All then underwent a new using novel - essential six...
Abstract Objective To measure the level of hair Mg, as well its in serum, patients with epilepsy and compare them to levels found non-epileptic age gender matched children, explore any potential correlation between either serum or magnesium seizure characteristics children idiopathic epilepsy. Methods An observational cross-sectional study including 50 100 control subjects. Cases were subjected full history taking, examination measurements magnesium, subjects only had their measured for...
Abstract Objective to measure the level of hair zinc, as well its in serum, patients with epilepsy and compare them levels found non-epileptic age gender matched children, explore any potential correlation between either serum or magnesium seizure characteristics children idiopathic epilepsy. Methods An observational cross-sectional study including 50 100 control subjects. Cases were subjected full history taking, examination measurements subjects only had their zinc measured for cases....