A5062469758- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Information Systems and Technology Applications
- CRISPR and Genetic Engineering
- Effects of Radiation Exposure
- Radiation Effects and Dosimetry
- Stonefly species taxonomy and ecology
- Pediatric health and respiratory diseases
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Biotechnology and Related Fields
- Diabetes Management and Research
- Enterprise Management and Information Systems
- Thermal Regulation in Medicine
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Technical Engine Diagnostics and Monitoring
- Carcinogens and Genotoxicity Assessment
- Biochemical effects in animals
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Respiratory and Cough-Related Research
- Adipose Tissue and Metabolism
Universitätsmedizin Rostock
2021
Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology
2008-2021
Ministry of Health of the Russian Federation
2017-2021
Omsk State Medical University
2015
Next generation sequencing has a potential to revolutionize the management of cancer patients within framework precision oncology. Nevertheless, lack standardization decelerated entering technology into clinical testing space. Here we dissected number common problems NGS diagnostics in oncology and introduced ways they can be resolved. DNA was extracted from 26 formalin fixed paraffin embedded (FFPE) specimens processed with TrueSeq Amplicon Cancer Panel (Illumina Inc, San Diego, California)...
Background : About 30% of cases hereditary breast cancer (BC) are associated with the BRCA1 and BRCA2 gene mutations. The absence programs mandatory genetic screening for BRCA -associated BC in Russia, as well an algorithm molecular testing does not allow fully accomplishing necessary preventive, diagnostic medical measures. Aim To elaborate patients order to improve efficacy identification nature disease. Materials methods study is based on analysis results 3826 aged from 22 90 years, who...
Introduction. Currently, there are conflicting data regarding the effect of c.470T> C germline mutation in CHEK2 gene on increasing risk breast cancer (BC), so it is necessary to conduct research large samples patients, including Russian population, order analyze contribution this developing. The aim study was determine frequency occurrence genetic variant c.470Т>С population patients with BC and benign diseases (BBD) assess possible deoxyribonucleic acid damage likelihood occurrence....
"Standard" diagnostic panels allow identification of only a few BRCA1 and BRCA2 gene mutations most common in population. Therefore, tests relying on such may return false negative results, since the coding regions these genes have other defects. For breast cancer (BC) patients, test results translate into selection inadequate therapy by their doctors. This study aimed to identify features BRCA-associated population Russian Federation. The included patients (n = 4440). At first stage, all...
This article discusses the current issues in pediatric practice of seasonal incidence children with acute respiratory infections. The basic etiological aspects this pathology, specific clinical symptoms typical for different pathogens, causes bursts disease certain periods are described. Special attention is paid to tactics antipyretic therapy groups fever and diseases, understand errors its appointment. author domestic foreign results using ibuprofen relieve comparative efficacy safety data...
One of the most serious problems radiotherapy is complications which occur in normal tissue after irradiation. Very often damage tissues caused by irradiation an obstacle for continuation treatment course. Therefore present paper oncological patients with different tumor types course have been studied. Damage was clinically registered; cytogenetic and molecular-biological changes blood cells were studied radiobiological researches. The level chromosome aberrations (cytogenetic method) DNA...
Ispol'zovanie «standartnyh» diagnosticheskih panelej, dayushchih vozmozhnost' opredelyat' lish' neskol'ko naibolee rasprostranennyh v populyacii mutacij genah BRCA1 i BRCA2, mozhet privodit' k poyavleniyu lozhnootricatel'nyh rezul'tatov iz-za nalichiya drugih povrezhdenij kodiruyushchih oblastyah dannyh genov, chto, svoyu ochered', privesti neadekvatnomu vyboru taktiki lecheniya u bol'nyh rakom molochnoj zhelezy (RMZH). Cel'yu raboty bylo vyyavit' osobennosti BRCA-associirovannogo raka...
Hintergrund Konsensusempfehlungen und Leitlinien sprechen sich für die Nutzung der kontinuierlichen Glukosemessung (CGM) aus. Diese Kohortenstudie hinterfragte den Zugewinn an Lebensqualität Patienten analysierte objektive Parameter Stoffwechsellage.