A5039608131- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Metal complexes synthesis and properties
- FOXO transcription factor regulation
- Proteoglycans and glycosaminoglycans research
- Cancer-related Molecular Pathways
- Fibroblast Growth Factor Research
- Photodynamic Therapy Research Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Oral health in cancer treatment
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Radiation Therapy and Dosimetry
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2025
Affiliated Hospital of Jining Medical University
2023
Jining Medical University
2023
Shanghai Chest Hospital
2023
Shanghai Jiao Tong University
2023
Third Hospital of Nanchang
2023
Oslo University Hospital
2020
University of Kansas Medical Center
2018-2019
Truman Medical Center
2018
Oral cancers can be preceded by clinically evident oral potentially malignant disorders (OPMDs). The current study evaluated the rate and time of transformation in various OPMDs a cohort patients from southern Taiwan. Parameters possibly indicative for OPMDs, such as epidemiological etiological factors, clinical histopathological features were also described. We followed-up 5071 with OPMDs—epithelial dysplasia submucous fibrosis, epithelial hyperkeratosis/epithelial hyperplasia, lichen...
EMT-6 murine mammary tumors were made resistant to cis-diamminedichloroplatinum (II) (CDDP), carboplatin, cyclophosphamide (CTX), or thiotepa in vivo by treatment of tumor-bearing animals with the drug during a 6-month period. In spite high levels resistance, no significant resistance was observed when cells from these exposed drugs vitro. The pharmacokinetics CDDP and CTX altered bearing respective tumors. all tumor lines except for EMT-6/thiotepa decreased 3 6 months passage absence drugs....
Abstract A cell-in-cell process refers to the invasion of one living cell into another homotypic or heterotypic cell. Different from non-apoptotic death processes internalized cells termed entosis cannibalism, we previously reported an apoptotic occurring during formation. In this study, further demonstrated that occurred only in immune killer expressing granzyme B (GzmB). Vacuole wrapping around inside target was common hallmark early stage all processes, which resulted accumulation...
Marine sponge-derived manoalide has a potent anti-inflammatory effect, but its potential application as an anti-cancer drug not yet been extensively investigated. The purpose of this study is to evaluate the antiproliferative effects on oral cancer cells. MTS assay at 24 h showed that inhibited proliferation six types cell lines (SCC9, HSC3, OC2, OECM-1, Ca9-22, and CAL 27) did affect normal line (human gingival fibroblasts (HGF-1)). Manoalide also inhibits ATP production from 3D sphere...
Glutamine is the primary fuel for gastrointestinal epithelium and maintains mucosal structure. Oncologists frequently encounter oral mucositis, which can cause unplanned breaks in radiotherapy (RT).The aim of this study was to explore association between glutamine acute toxicities patients with head neck cancer undergoing RT.This a parallel, double-blind, randomized, placebo-controlled Phase III trial conducted university hospital. A central randomization center used computer-generated...
Visfatin, an adipocytokine highly expressed in breast tumor tissues, is associated with cancer progression. Recent studies showed that adipocytokines mediate development through tumor-stromal interactions the microenvironment. This study focused on interaction between one key stromal constituent—tumor-associated macrophages—and visfatin. Pretreatment of THP-1 and peripheral blood mononuclear cells (PBMCs) recombinant visfatin resulted M2-polarization determined by CD163 CD206 expression....
Withaferin A (WFA) has been reported to inhibit cancer cell proliferation based on high cytotoxic concentrations. However, the low effect of WFA in regulating migration is rarely investigated. The purpose this study investigate changes and mechanisms oral Ca9-22 cells after concentrations treatment. under 0.5 μM at 24 h treatment shows no cytotoxicity (~95% viability). Under condition, triggers reactive oxygen species (ROS) production inhibits 2D (wound healing) 3D (transwell) Matrigel...
Some lichens provide the resources of common traditional medicines and show anticancer effects. However, effect Usnproliea barbata (U. barbata) is rarely investigated, especially for oral cancer cells. The aim this study was to investigate cell killing function methanol extracts U. (MEUB) against MEUB shows preferential a number lines (Ca9-22, OECM-1, CAL 27, HSC3, SCC9) but affects normal (HGF-1). Ca9-22 OECM-1 cells display highest sensitivity were chosen concentration time course...
Lung cancer is a malignancy with high mortality worldwide, and metastasis occurs at frequency even when spread not detectable primary operation. Cancer stemness plays an important role in malignant behavior, treatment resistance, metastasis. Therefore, understanding the molecular pathogenesis behind cancer-stemness-mediated developing effective approaches to prevent are key issues for improving treatment. In this study, we investigated of CD44 marker lung using vitro clinical studies....
Abstract Background Interleukin-1 receptor antagonist (IL-1RA), a member of the IL-1 family, has diverse roles in cancer development. However, role IL-1RA oral squamous cell carcinoma (OSCC), particular underlying mechanisms, remains to be elucidated. Methods Tumor tissues from OSCC patients were assessed for protein expression by immunohistochemistry. Patient survival was evaluated Kaplan–Meier curve analysis. Impact differential on cultured lines vitro clonogenic survival, tumorsphere...
Breast cancer is the most common female-specific malignancy in Taiwan and developed countries worldwide, its incidence continues to grow. 14-3-3ε (YWHAE), which belong 14-3-3 family, it has been reported up-regulated breast tissues. However, clinical implication function of YWHAE remains unclear. In this study, we investigated prognostic value human cancer. Immunohistochemistry was used analyze expression Cell model applied examine functions YWHAE. The chemotherapeutic agents were evaluate...
Adipose-derived stem cells (ADSCs) have been implicated in tumor growth and metastasis breast cancer. ADSCs exhibit tropism, are of increasing clinical relevance due to the autologous fat grafting for reconstruction. Although we previously shown that a high level adipocytokine visfatin human cancer tissues correlated with progression mediated by cAbl STAT3, effects microenvironment unclear. To understand how modulates within tumor-stromal environment, examined determinants using...
Abstract MRE11, the nuclease component of RAD50/MRE11/NBS1 DNA repair complex which is essential for double-strand-breaks in normal cells, has recently garnered attention as a critical factor solid tumor development. Herein we report crucial role MRE11 oral cancer progression nuclease-independent manner and delineate its key downstream effectors including CXCR4. expression samples was positively associated with size, stage lymph node metastasis, predictive poorer patient survival...
The primary cause of breast cancer mortality is the metastatic invasion cancerous stem cells (CSC). Cluster differentiation 44 (CD44) a well-known CSC marker in various cancers, as well key role player metastasis and relapse cancer. CD44 cell-membrane embedded protein, it interacts with different proteins to regulate cell behavior. Transcription factor forkhead box protein A2 (FOXA2) acts an important regulator multiple including However, biological significance CD44-FOXA2 association...
Many genetic factors play an important role in the development of oral squamous cell carcinoma. The aim this study was to assess mutational profile carcinoma using formalin-fixed, paraffin-embedded tumors from a Taiwanese population by performing targeted sequencing 26 cancer-associated genes that are frequently mutated solid tumors.Next-generation performed 50 tumor specimens obtained patients with Genetic alterations were detected deep (>1000X) approach.TP53, PIK3CA, MET, APC, CDH1, and...
Abstract The tumor microenvironment represents one of the main obstacles in breast cancer treatment owing to presence heterogeneous stromal cells, such as adipose-derived stem cells (ADSCs), that may interact with and promote development. Resistin is an adipocytokine associated adverse progression; however, its underlying mechanisms context remain largely unidentified. Here, we utilized a transwell co-culture model containing patient-derived ADSCs cell lines investigate their potential...
Betel quid and its major ingredient, areca nut, are recognized by IARC as risk factors in oral cancer development. Areca nut extract (ANE) exposure has been linked to OPMD progression malignant transformation OSCC. However, the detailed mechanism through which ANE acts on other cell types microenvironment promote carcinogenesis remains elusive.
<title>Abstract</title> Breast cancer is the most prevalent among women. Previous studies demonstrated that adipose-derived stem cells (ADSCs) co-cultured with resistin promote malignant behaviors in breast cells. This study explores roles of ADSCs and adipocytokine within tumor microenvironment, emphasizing their contributions to metabolic reprogramming progression. RNA sequencing analysis pathways revealed co-culture resistin-treated exhibited elevated expression NDUFS1, largest subunit...