A5101523300- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Drug Transport and Resistance Mechanisms
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Endometriosis Research and Treatment
- Nausea and vomiting management
- COVID-19 and healthcare impacts
- Anesthesia and Pain Management
- Neuroblastoma Research and Treatments
- Management of metastatic bone disease
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Hemoglobin structure and function
- Anorectal Disease Treatments and Outcomes
- Lung Cancer Research Studies
- Parathyroid Disorders and Treatments
- COVID-19 Clinical Research Studies
- Thyroid Cancer Diagnosis and Treatment
Beijing Chao-Yang Hospital
2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2020-2023
Kaohsiung Medical University
2020-2023
Vivantes Klinikum
2020-2022
Charité - Universitätsmedizin Berlin
2013-2021
Humboldt-Universität zu Berlin
2021
Freie Universität Berlin
2021
Mayo Clinic in Florida
2020
WinnMed
2020
Weill Cornell Medicine
2020
SARS-CoV-2 (COVID-19) is a systemic infection. Patients with cancer are immunocompromised and may be vulnerable to COVID-related morbidity mortality. The objectives of this study were determine if patients have worse outcomes compared without identify demographic clinical predictors mortality among cancer.
The influence of positron emission tomography in the management recurrent rectal cancer is well established but its role primary remains uncertain. This study therefore prospectively assesses impact position scanning on cancer.Forty-six patients with advanced referred for consideration adjuvant preoperative therapy underwent scanning. referring physicians recorded each patient's stage following conventional imaging and proposed treatment plan prior to was then compared subsequent actual...
<h3>Objective</h3> This study aimed to analyze the prognostic factors for overall and progression-free survival in patients with vulvar cancer. <h3>Methods</h3> international, multicenter, retrospective included 2453 diagnosed cancer at 100 different institutions. Inclusion criteria were institutional review board approval from each collaborating center, pathologic diagnosis of invasive carcinoma vulva, primary treatment performed participating center. Patients intraepithelial neoplasia or...
PURPOSE: Treatment of chronic radiation proctitis remains unsatisfactory. Short-chain fatty acids are the preferred energy source for colonic epithelium. We aimed to determine first time whether topical butyric acid enemas relieve symptoms and improve macroscopic microscopic findings in proctitis. METHODS: A randomized, double-blind, placebo-controlled, cross-over pilot trial compared patients given two weeks (40 mmol) twice per day with those placebo, a one-week washout period; 15 were...
Glutamine is the primary fuel for gastrointestinal epithelium and maintains mucosal structure. Oncologists frequently encounter oral mucositis, which can cause unplanned breaks in radiotherapy (RT).The aim of this study was to explore association between glutamine acute toxicities patients with head neck cancer undergoing RT.This a parallel, double-blind, randomized, placebo-controlled Phase III trial conducted university hospital. A central randomization center used computer-generated...
Objective: To examine the initial impact of National Bowel Cancer Screening Program (NBCSP), which was launched in May 2006 and offers faecal occult blood testing to Australians aged 55 or 65 years. Design setting: Review data on colorectal cancer (CRC) cases diagnosed between June 2008 from a prospective database used at 19 Australian hospitals, linked analysed by BioGrid Australia. Main outcome measures: Number CRC detected through NBCSP symptomatic presentation, differences sex, stage...
Abstract Several life‐prolonging therapies for metastatic castration‐resistant prostate cancer (mCRPC) are available, including radium‐223 dichloride ( 223 Ra), which was approved based on phase 3 data demonstrating improved overall survival (OS) and a favorable safety profile. To date, real‐world evidence Ra use in Taiwan is from three studies of <50 patients. This observational study (NCT04232761) enrolled male patients with histologically/cytologically confirmed mCRPC bone metastases...
The aim of this study was to determine if local recurrence (LR) rates in patients with minimally invasive and advanced T3 rectal cancer are different. This may influence the use adjuvant therapy.Consecutive undergoing curative surgery were classified into or groups. Minimally defined as a tumour that had invaded beyond muscularis propria on microscopic examination only, whereas tumours invasion obvious macroscopic confirmed histologically. Local two groups compared by construction...
Intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) reduces overall treatment duration and results in less (RT)-induced dermatitis. However, the use of traditional sequential approach or IMRT-SIB is still under debate since there not enough evidence long-term clinical outcomes. The present study investigated 216 patients who underwent breast conserving surgery (BCS) between 2010 2013. median age was 51 years (range, 21-81 years). All received IMRT-SIB, 50.4 Gy at...
Abstract Background To evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen 125 (CA125) and risk malignancy algorithm (ROMA) to ultrasound for detecting ovarian in patients with a pelvic mass. Methods This was prospective, observational, multicenter study. Patients aged > 18 years who were scheduled undergo surgery suspicious mass had CA125 HE4 levels measured prior surgery, addition routine transvaginal scan. The performance CA125, ROMA distinguishing...
The apical sodium-dependent bile acid transporter (ASBT, SLC10A2) mediates intestinal, renal, and cholangiocyte reclamation. Transcriptional regulation of ASBT is well described, whereas information on posttranscriptional limited. Prior studies suggested that ontogeny controlled in part by changes messenger RNA (mRNA) stability. We studied the role Hu antigen R (HuR) tristetraprolin (TTP) play regulating expression mRNA contains 3' untranslated region (UTR) rat ASBT. 3'UTR was incorporated...
Abstract Background: Lymph node yield (LNY) is a measure of quality care and strong prognostic factor for outcome from colorectal cancer (CRC). The main aims this study were to determine LNY across multiple Australian centres the clinico‐pathologic factors that influence yield. Methods: Analysis data prospective CRC databases at 11 between January 1988 May 2008 was undertaken utilizing linkage analysis resources BioGrid Australia. depending on different patient characteristics evaluated....
Fibroblast growth factor-19 (FGF-19), a bile acid-responsive enterokine, is secreted by the ileum and regulates variety of metabolic processes. These studies examined signal transduction pathways operant in FGF-19-mediated repression apical sodium-dependent acid transporter (ASBT). Responses to FGF-19 were assessed Caco-2 CT-26 cells mice where c- fos was conditionally silenced intestine cre-lox strategy. treatment or wild-type led significant reduction ASBT protein expression enhanced...
Functional defects in ATPase class I type 8B membrane 1 (ATP8B1 or familial intrahepatic cholestasis 1, FIC1) lead to by mechanism(s) that are not fully understood. One proposed pathophysiology involves aberrant signaling the bile acid sensor, farnesoid X receptor (FXR), via protein kinase C ζ (PKCζ). The following cell line-based studies investigated whether phospholipase D2 may transduce a signal from FIC1 FXR. PLD2 gain of function led activation salt export pump (BSEP) promoter,...
Rationale: Radiotherapy (RT) is widely used for both malignant and benign tumors in order to reduce the risk of recurrence, promote tumor control, improve survival. However, there have been studies reported that RT also a factor secondary cancer. Very few cases malignancy after high grade brain cancer due short survival this disease, most RT-induced malignancies presented with sarcomatous histology. Here we present patient basal cell carcinoma (BCC) 14 years his brain. Patient concerns: A...
Abstract Child abuse (CA) is a strong predictor of psychopathologies and suicide, altering normal trajectories brain development in areas closely linked to emotional responses such as the prefrontal cortex (PFC). Yet, cellular underpinnings these enduring effects are unclear. Childhood adolescence marked by protracted formation perineuronal nets (PNNs), which orchestrate closure developmental windows cortical plasticity regulating functional integration parvalbumin interneurons (PV) into...