A5102815627- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
- Pregnancy and Medication Impact
- Blood disorders and treatments
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Acute Lymphoblastic Leukemia research
- Reproductive System and Pregnancy
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Impact on Reproduction
- Glutathione Transferases and Polymorphisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Rabbits: Nutrition, Reproduction, Health
- Venous Thromboembolism Diagnosis and Management
- Surgical site infection prevention
- Glioma Diagnosis and Treatment
- Autophagy in Disease and Therapy
National Cancer Institute
2021-2022
University of Oklahoma Health Sciences Center
2010-2020
OU Health
2017-2020
Takeda (United States)
2005-2019
Deerfield (United States)
2018
University of Oklahoma
2013-2014
University of Alabama at Birmingham
2006-2008
Newcastle upon Tyne Hospital
2005
Children's Health Ireland at Crumlin
2002
Our Lady's Hospital
2002
Documented rarity, diagnostic difficulty and poor results stimulated this study of 79 malignant 37 benign small bowel tumors in order to emphasize these lesions, determine their symptomatology improve diagnosis results, particularly the group. Chief symptoms were recurrent abdominal pain tenderness, signs obstruction gastrointestinal bleeding. Fourteen cases asymptomatic. The mean symptom-diagnosis interval was 6.6 months. Roentgenographic contrast studies helpful diagnosing 33 43 patients,...
The transcription factor nuclear E2-related 2 (Nrf2) induces the expression of antioxidant gene products that neutralize reactive oxygen species and restore redox homeostasis. Nrf2 is constitutively degraded by ubiquitin proteolytic system in unperturbed cells, but this turnover arrested response to oxidative stress, thereby leading accumulation. Yet, a mechanistic understanding how stabilization transcriptional activation are coupled remains be determined. We have discovered...
One hundred and sixty-one evaluable patients with biopsy-confirmed transitional cell carcinoma of the bladder were studied in a cooperative protocol comparing intravesical BCG adriamycin. Patients have been followed for 2–25 months (median 15.7 months) cystoscopy at 3-month intervals, urinary cytology, biopsy. Sixteen 88 (19%) who received immunotherapy developed tumor recurrence compared 45 recurrences (54%) 83 adriamycin chemotherapy (p < 0.001, Χ2). Eighty-nine randomized had documented...
G2E3 is a putative ubiquitin ligase (E3) identified in microarray screen for mitotic regulatory proteins. It shuttles between the cytoplasm and nucleus, concentrating nucleoli relocalizing to nucleoplasm response DNA damage. In this study, we demonstrate that an unusual essential early embryonic development prevent apopotic death. This protein has catalytically inactive HECT domain two distinct RING-like domains catalyze lysine 48-linked polyubiquitination. To address vivo function,...
Abstract VPS45 ‐associated severe congenital neutropenia (SCN) is a rare disorder characterized by life‐threating infections, neutropenia, neutrophil and platelet dysfunction, poor response to filgrastim, myelofibrosis with extramedullary hematopoiesis. We present patient SCN due homozygous c.1403C>T (p.P468L) mutation in , critical regulator of SNARE‐dependent membrane fusion. Structural modeling indicates that P468, like the T224 E238 residues affected previously reported mutations,...
Vedolizumab, a humanized monoclonal antibody approved for the treatment of adults with moderately to severely active ulcerative colitis or Crohn disease, targets α 4 β 7 integrin and selectively blocks gut-specific lymphocyte trafficking. The potential effects vedolizumab on development were assessed by standard preclinical toxicity studies in rabbits cynomolgus monkeys. A single infusion (0, 10, 30, 100 mg/kg) was administered intravenously pregnant gestational day 7; monitored 29....
Cerebral malaria (CM) is a severe clinical complication of Plasmodium falciparum infection and characterized by high fatality rate neurological damage. Sequestration parasite-infected red blood cells in brain microvasculature utilizes host- parasite-derived adhesion molecules an important factor the development CM. ICAM-1, alternatively spliced molecule, believed to be critical on endothelial for infected cell sequestration Using ICAM-1 mutant mice, we found that full-length isoform not...
Purpose: Lubiprostone (L) is a novel bicyclic fatty acid that selectively stimulates GI ClC-2 chloride channels. Fatty acids induce relaxation or contraction of smooth muscle, depending on tissue type. This study compares the activity L muscle with other acids. Methods: The agonist via prostaglandin (PG) receptors was assessed by measuring ileum longitudinal (EP1 receptor), circular twitch inhibition (EP2 vas deferens (EP3 iris sphincter (FP receptor). Activity expressed as percentage PGE2...
Abstract: Adult T‐cell leukemia/lymphoma is a malignancy caused by the human lymphotropic virus‐I. primarily disease of adults due to long latency period between initial infection and development leukemia. We present case acute adult in an adolescent. Skin lesions had appeared 3 years earlier were sign virus‐I malignancy. Her failed respond both intensive chemotherapy antiviral therapy. Cutaneous are sometimes early recognition imperative.
G2E3 is a G2 /M-specific gene that down-regulated in response to DNA damage. It highly regulated at both the transcriptional and post-translational levels. plays critical role early embryonic development, as murine G2E3-deficient blastula undergoes massive apoptosis. To identify proteins interacting with yeast two-hybrid was conducted, which revealed eight putative G2E3-binding including two ubiquitin ligases (RNF138/NARF, DZIP3/hRUL138), proteasomal subunit (PSMB4), one cell cycle...
A previously healthy 11 year old boy died unexpectedly after a rapid course of progressive pneumonia. Postmortem microbiology and histopathology suggested an underlying diagnosis chronic granulomatous disease. This was confirmed by neutrophil oxidative burst gene mutation analysis other family members, one whom benefited from early bone marrow transplantation.
Purpose: Lubiprostone, under development for chronic idiopathic constipation, is a selective GI ClC-2 chloride channel activator. Preclinical assessment of lubiprostone (L) demonstrates minimal toxicity. The following studies evaluate reproductive and developmental effects in rats. Methods: For reproduction, 0.04, 0.2, or 1.0 mg/kg/day L was administered by oral gavage. In male rats dosing 4 weeks prior to mating 35 days from end third mating; female 14 mating, 15 during 7 pregnancy. Male...
Purpose: Lubiprostone (L), a novel bicyclic fatty acid derivative under development for the treatment of chronic idiopathic constipation and irritable bowel syndrome, increases intestinal fluid secretion via selective activation GI ClC-2 chloride channels without altering blood levels sodium or potassium. Clinical studies have shown that L relieves improves associated symptoms, such as bloating straining. This study aims to characterize pharmacokinetic profile in mouse, rat, rabbit, dog,...
Purpose: Lubiprostone (L), in development for chronic idiopathic constipation and constipation-predominant IBS, is a selective GI chloride channel-2 (ClC-2) activator that increases intestinal fluid secretion. These studies compare the vivo metabolic profiles of L different species. Methods: Mouse, rat, dog, monkey were orally administered [3H]-L: 50 μg/kg mouse 5 dog monkey. Blood samples collected periodically from min to 48 h postdosing, urine feces 0–144 postdosing. Results: The maximum...
Pediatric patients with malignancies are at significant risk for complications from their underlying condition and medical therapy. Emergency medicine physicians must be quick to suspect life-threatening events, which can present insidiously. We describe a case of anaphylaxis superior vena cava syndrome in an 18-year-old female patient after polyethylene glycol-conjugated asparaginase chemotherapy acute lymphoblastic leukemia. Pertinent literature surrounding factors, diagnosis, treatment is...
Abstract Systemic mastocytosis is a rare entity in pediatrics, usually associated with mutations the c‐KIT gene. We describe Caucasian female who presented severe systemic food allergies requiring prolonged total parenteral nutrition. Her course was further complicated by onset of hemophagocytic lymphohistiocytosis, which responded poorly to conventional chemotherapy. She underwent an allogeneic hematopoietic stem cell transplant that resulted resolution all symptoms related and...
Vedolizumab (VDZ) is a gut-selective humanised monoclonal antibody targeting α4β7 integrin, approved for adults with moderate-to-severe ulcerative colitis and Crohn’s disease. The few publications reporting on VDZ use in pregnancy have not identified any incidence of maternal or foetal toxicity. objective this study was to evaluate the effects pregnancy, parturition lactation cynomolgus monkeys survival, growth postnatal development offspring. Non-fasted pregnant were randomly assigned...