A5078316879- Systemic Sclerosis and Related Diseases
- Lymphatic System and Diseases
- Dermatological and Skeletal Disorders
- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Esophageal and GI Pathology
- Lymphatic Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Medicinal Plant Extracts Effects
- Phytochemicals and Antioxidant Activities
- Urological Disorders and Treatments
- Body Contouring and Surgery
- Anorectal Disease Treatments and Outcomes
- Sympathectomy and Hyperhidrosis Treatments
- Genetic and Kidney Cyst Diseases
- Hernia repair and management
- Dysphagia Assessment and Management
- Antioxidant Activity and Oxidative Stress
- Pelvic floor disorders treatments
University of Siena
2013-2020
Background: Lymphedema is characterized by an accumulation of interstitial fluids due to inefficient lymphatic drainage. Primary lymphedema a rare condition, including congenital and idiopathic forms. Secondary common complication lymph node ablation in cancer treatment. Previous studies on secondary vessels have shown that after initial phase ectasia, worsening the disease associated with wall thickening accompanied progressive loss endothelial marker podoplanin. Methods Results: We...
In systemic sclerosis (SSc), dermal capillaries are progressively lost with consequent chronic tissue hypoxia insufficiently compensated by angiogenesis. Clinical studies reported that intravenous cyclophosphamide (CYC) may improve SSc-related peripheral microvascular damage. Recently, we showed CYC treatment normalize SSc sera-induced abnormalities in endothelial cell-matrix interactions. Our objective was to evaluate vitro the effects of sera from treatment-naïve or CYC-treated patients on...
Abstract Background Anal incontinence is a disabling condition that adversely affects the quality of life large number patients, mainly with anal sphincter lesions. In previous experimental work, in-vitro expanded bone marrow (BM)-derived mesenchymal stem cells (MSC) were demonstrated to enhance healing after injury and primary repair in rat preclinical model. present article we investigated whether unexpanded BM mononuclear (MNC) may also be effective. Methods Thirty-two rats, divided into...
Blood pressure control in hypertensive subjects calls for changes lifestyle, especially diet. Tomato is widely consumed and rich healthy components (i.e., carotenoids, vitamins polyphenols). The aim of this study was to evaluate the chemical composition antihypertensive effects locular gel reconstituted serum green tomatoes “Camone” variety. were chemically characterised. serum, pure tomatine, captopril, administered by oral gavage, investigated 4 weeks male spontaneously normotensive rats....
Systemic sclerosis (SSc) is a connective tissue disorder characterized by endothelial cell injury, autoimmunity and fibrosis. The following three fibrillin-1 alterations have been reported in SSc. (1) Fibrillin-1 microfibrils are disorganized SSc dermis. (2) produced fibroblasts unstable. (3) Mutations the FBN1 gene anti-fibrillin-1 autoantibodies microfibrils, which abundantly blood lymphatic microvascular cells (B-MVECs Ly-MVECs, respectively), sequester extracellular matrix latent form of...
Abstract Background Over the last 15 years, many studies demonstrated myogenic regenerative potential of bone marrow mesenchymal stem cells ( BM ‐ MSC ), making them an attractive tool for regeneration damaged tissues. In this study, we have developed animal model esophagogastric myotomy MY ) aimed at determining role autologous in lower esophageal sphincter LES after surgery. Methods Syngeneic were locally injected site . Histological and functional analysis performed to evaluate muscle...
Systemic sclerosis (SSc, scleroderma) is characterized by fibrosis of the skin and internal organs, autoantibodies diffuse microangiopathy. In SSc, fibrillin-1 microfibrils are disorganized unstable. Mutations in FBN1 gene anti-fibrillin- 1 have also been reported SSc patients. Fibrillin-1 sequester extracellular matrix latent form potent pro-fibrotic cytokine transforming growth factor-β (TGF-β). We herein report effects sera on deposition microfibril-associated glycoprotein-1 (MAGP-1)...
<h3>Background</h3> Systemic sclerosis (SSc) is a complex connective tissue disease characterized by extensive fibrosis and vascular abnormalities. Dermal capillaries are progressively reduced in number with consequent chronic hypoxia insufficiently compensated angiogenesis. In SSc, clinical studies reported that cyclophosphamide (CYC) treatment may significantly improve nailfold capillary damage. Moreover, our group has recently shown the beneficial effects of CYC SSc be due part to...
In pulmonary fibrosis, the usual interstitial pneumonia (UIP) pattern is characterised by heterogeneous, patchy with areas of normal lung adjacent to complete destruction (honeycombing) and fibroblastic foci (FF). The NSIP which characteristic systemic sclerosis, a more homogeneous involvement without honeycombing FF. Little known on lymphatic vessels in fibrosis. Defective clearance could lead prolonged exposure pathogenic antigens and/or pro-inflammatory/pro-fibrotic mediators. We...
Systemic sclerosis (SSc) is a connective tissue disorder of unknown ethiology with two different subsets: limited (lSSc) and diffuse cutaneous systemic (dSSc) patterns organ involvement, autoantibody profiles survival (1). The disease characterized by three major features: vascular endothelial injury, inflammation/autoimmunity massive deposition collagen. Many extracellular matrix proteins are altered in SSc, including fibrillin (2). Fibrillin microfibrils form anchoring filaments lymphatic...
Background. The incompetence of lower esophageal sphincter (LES) with consequent exposition the mucosa to gastric acid leads gastroesophageal reflux disease. aim this study was evaluate whether intralesional injections Bone Marrow Mesenchymal Stem Cells (BM-MSC), which proved useful in treatment urinary (1) and anal (2) incontinence, could also help muscle regeneration at site surgical myotomy rat LES. Methods. 24 inbred Wistar Furth rats were divided into three groups: group A underwent a...