A5059795410- Lymphatic System and Diseases
- Sympathectomy and Hyperhidrosis Treatments
- History of Medicine Studies
- Linguistics and Cultural Studies
- Oropharyngeal Anatomy and Pathologies
- Medical History and Innovations
- Inflammatory Myopathies and Dermatomyositis
- Urological Disorders and Treatments
- Anatomy and Medical Technology
- Cleft Lip and Palate Research
- Sexual Differentiation and Disorders
- Pediatric Urology and Nephrology Studies
- Congenital gastrointestinal and neural anomalies
- Medical and Biological Sciences
- Pain Mechanisms and Treatments
- Testicular diseases and treatments
- Cellular Mechanics and Interactions
- Eosinophilic Disorders and Syndromes
- Congenital Anomalies and Fetal Surgery
- Skin and Cellular Biology Research
- Myofascial pain diagnosis and treatment
- Epigenetics and DNA Methylation
- Nerve Injury and Rehabilitation
- Alkaline Phosphatase Research Studies
- Intestinal Malrotation and Obstruction Disorders
University of Siena
2014-2024
Toscana Life Sciences
2019
Objectives: The objective of this study was to identify specific histopathological features skeletal muscle involvement in systemic sclerosis (SSc) patients. Methods: A total 35 out 112 SSc-patients (32%, including 81% female and 68% diffuse scleroderma) presenting clinical, biological electromyographic (EMG) weakness, were included. Patients underwent vastus lateralis biopsy, assessed for individual pathologic fibrosis [type I collagen (Coll-I), transforming growth factor β (TGF-β)],...
Cannabinoids help in pain treatment through their action on CB1 and CB2 receptors. β-caryophyllene (BCP), an ancient remedy to treat pain, is a sesquiterpene found large amounts the essential oils of various spice food plants such as oregano, cinnamon black pepper. It binds receptor, acting full agonist. Sex differences BCP-induced analgesic effect were studied by exposing male female rats persistent/repeated painful stimulation. To simulate repeated inflammatory condition, after first...
Background: Lymphedema is characterized by an accumulation of interstitial fluids due to inefficient lymphatic drainage. Primary lymphedema a rare condition, including congenital and idiopathic forms. Secondary common complication lymph node ablation in cancer treatment. Previous studies on secondary vessels have shown that after initial phase ectasia, worsening the disease associated with wall thickening accompanied progressive loss endothelial marker podoplanin. Methods Results: We...
Background Little is known about the morphology of precollectors, lymphatic vessels connecting absorbing and collecting vessels, which are regarded as initial drainage routes lymph. The aim this study was to describe structural features human precollectors. Methods Samples fat from around saphenous veins were obtained patients undergoing varicotomy, serial sections observed under light transmission electron microscopy. Tridimensional reconstructions also by computer analysis. Results...
To investigate expression of vascular endothelial growth factor (VEGF) antiangiogenic isoform A-165b on human muscle in idiopathic inflammatory myopathies (IIM) and to compare distribution angiogenic/antiangiogenic VEGFs, as isoforms shifts are described other autoimmune disorders.We analyzed VEGF-A165b VEGF-A by western blot immunohistochemistry skeletal biopsies from 21 patients affected with IIM (polymyositis, dermatomyositis, inclusion body myositis) 6 control samples. TGF- β, a...
Colchicine, a long established anti-inflammatory agent now used in several rheumatologic conditions, acts by inhibiting microtubular polymerization, as it binds equimolarly to tubulin molecules. Cytoskeletal microtubules are crucial processes of cell viability, such mitosis and intracellular vesicle motility.Gastrointestinal side effects quite common often minor nature or duration, whereas neuromuscular toxicity is rare. We report 2 cases colchicine myopathy the context very different...
Aims: ( a ) To evaluate tissue eosinophil density, location of cytotoxic products, histopathological muscle changes and inflammatory cell types in different eosinophilia-associated myopathies that are clinicopathologically heterogeneous. b determine the immunohistological range density non-eosinophilic myopathies. Methods: Muscle biopsy specimens from seven patients with blood and/or eosinophilia clinicolaboratory myopathic signs (five chronic course myopathies, one subacute onset...
Aspects of memory involved in cognitive mechanisms were investigated rat after oxaliplatin (OX) chemotherapy using animal behavioural assessment passive avoidance and social learning paradigms, which are both hippocampus-sensitive. Rodents, previously subjected to 2-week OX treatment, showed impairment apoptotic processes the hippocampus. Apoptosis rate significantly increased cultured hippocampal cells exposed at increasing doses, this effect was dose-dependent. Ex vivo experiments that...
The endothelium is a metabolically active organ that regulates the interaction between blood or lymph and vessel surrounding tissue. Blood has been object of many investigations whereas lymphatic biology yet poorly understood. This report deals with proteomic approach to characterization comparative analysis endothelial cells (ECs). By 2-DE we visualized protein profiles EC extracts from thoracic aorta, inferior vena cava, duct Bos taurus. three obtained electropherograms were then analyzed...
PURPOSE: The aim of this study was to determine why colorectal tumors confined submucosa rarely metastasize. Under normal conditions, the contains many large lymphatic vessels with thin walls that would presumably favor spread cancer cells through system. METHODS: Specimens tissue, border between tumor and tissue were obtained from patients undergoing radical resection cancer. material embedded in methacrylate resin for light microscopy Epon® transmission electron examination. Light...
<b><i>Aim:</i></b> To describe architecture and expression of myosin isoforms the human cremaster muscle (CM) to individuate changes in clinically differentiated abnormalities testicular descent: cryptorchidism or undescended testis (UDT) retractile (RT). <b><i>Background:</i></b> The CM is a nonsomitic striated differentiating from mesenchyme gubernaculum testis. Morphofunctional molecular peculiarities linked its unique embryological origin...
The hypoglossal canal is a dual bone at the cranial base near occipital condyles. filaments of nerve pass through canal. It also transmits meningeal branch ascending pharyngeal artery, venous plexus and branches nerve. innervates all intrinsic extrinsic muscles tongue except palatoglossal fundamental in physiological functions as phonation deglutition. A surgical approach to requires knowledge main morphometric data by neurosurgeons.The present study was carried out on 50 adult dried skulls:...
Endothelin-1 (ET-1), a potent vasoconstrictor peptide, is involved in several functions of eye pathophysiology, such as regulation intraocular tension and retinal reactive vasoconstriction. As ET-1 pro-inflammatory fibrosing activity emerging different fields pathology, we investigated the expression endothelin-converting enzyme-1 (ECE-1) chalazia, granulomatous lesions eyelid. ECE-1 were analyzed by immunohistochemistry (IHC) twenty surgically removed with regard to eyelid structures...
Immunohistological studies on lymphatics’ topography in human peripheral nerve are few and recent. By D2-40 immunohistochemistry, we previously described lymphatics epineurium of sural nerve. Lymphangiogenesis is inflammation. In angiopathic vasculitic neuropathies proliferation epineurial blood capillaries reported. The aim our study therefore to investigate the density search possible correlation with capillary neovascularization different neuropathies. We examined biopsied nerves patients...