A5010479186- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Nausea and vomiting management
- Chemotherapy-induced organ toxicity mitigation
- Viral-associated cancers and disorders
- Anesthesia and Pain Management
- Renal cell carcinoma treatment
- Multiple Sclerosis Research Studies
- Philosophy and Theoretical Science
- Oral and Maxillofacial Pathology
- Infectious Encephalopathies and Encephalitis
- Cancer Genomics and Diagnostics
- Polyomavirus and related diseases
- Breast Cancer Treatment Studies
- Pituitary Gland Disorders and Treatments
- Classical Philosophy and Thought
- Peripheral Neuropathies and Disorders
- Facial Nerve Paralysis Treatment and Research
- Ocular Diseases and Behçet’s Syndrome
- Ethics and Social Impacts of AI
- Cancer Diagnosis and Treatment
- Chemokine receptors and signaling
- Bacterial Infections and Vaccines
- Philosophical Ethics and Theory
- Psychology of Moral and Emotional Judgment
University of L'Aquila
2019-2024
Azienda Ospedaliera Universitaria Senese
2007-2020
University of Siena
1999-2020
University of Verona
2017
Medica (Italy)
2013-2016
Arcispedale Sant'Anna
1992-2015
National Institute of Neurological Disorders and Stroke
2003-2014
National Institutes of Health
2005-2014
University of Florence
2011
Fondazione IRCCS Istituto Nazionale dei Tumori
2003
Ondansetron (OND) is a new 5-HT3 receptor antagonist that give complete protection from emesis/nausea in approximately 50% of cisplatin (CDDP)-treated patients. To evaluate if dexamethasone (DEX) added to OND increases antiemetic efficacy, we carried out double-blind randomized crossover study compare the activity with plus DEX. One hundred two chemotherapy-naive patients (44 women and 58 men) scheduled receive CDDP chemotherapy at doses greater than or equal 50 mg/m2 entered study....
Human herpesvirus-6 (HHV-6), a ubiquitous beta-herpesvirus, is the causative agent of roseola infantum and has been associated with number neurologic disorders including seizures, encephalitis/meningitis, multiple sclerosis. Although role HHV-6 in human CNS disease remains to be fully defined, studies have suggested that can site for persistent infection.To characterize extent distribution glial cells from surgical brain resections patients mesial temporal lobe epilepsy (MTLE).Brain samples...
Human herpesvirus-6 (HHV-6) is a beta-herpesvirus with 90% seroprevalence that infects and establishes latency in the central nervous system. Two HHV-6 variants are known: HHV-6A HHV-6B. Active infection or reactivation of brain associated neurological disorders, including epilepsy, encephalitis, multiple sclerosis. In preliminary study, we found HHV-6B DNA resected tissue from patients mesial temporal lobe epilepsy (MTLE) have localized viral antigen to glial fibrillary acidic protein...
We designed a multicenter, double-blind randomized study to determine the safety and antiemetic effectiveness of intravenous (IV) methylprednisolone (P) combined with high-dose IV metoclopramide (MTC) v MTC alone in 200 untreated cancer patients receiving cisplatin chemotherapy. One hundred eighty-five were evaluable for treatment efficacy. plus P was significantly superior reducing number length vomiting episodes (P = .001 .0008, respectively) maximal intensity nausea .0124 score system;...
Despite treatment, emesis remains a major problem with cisplatin (CDDP) chemotherapy. Reasons for variability in antiemetic response among patients and subsequent cycles are largely unknown toxicity is sometimes severe. We have, therefore, carried out multicenter, double-blind randomized trial comparing combination of high-dose metoclopramide (MTC) (1 mg/kg x 4) methylprednisolone (P) (treatment A) shorter but higher single-dose schedule (3 2) combined dexamethasone (DEX) diphenhydramine...
One-half of bone-marrow transplant (BMT) and stem-cell recipients have reactivation latent human herpesvirus (HHV)-6 2–4 weeks after transplant. Although the detection viral DNA, RNA, antigen in brain material confirmed active HHV-6 variant B infection, peak loads cerebrospinal fluid (CSF) serum occurred before death decreased to low levels or at autopsy. All autopsy samples consistently demonstrated infection hippocampus. Astrocytic cells positive for provided support an HHV-6-specific...
Though first described as a lymphotropic virus, human herpesvirus 6 (HHV-6) is highly neuropathogenic. Two viral variants are known: HHV-6A and HHV-6B. Both can infect glial cells have been differentially associated with central nervous system diseases, suggesting an HHV-6 variant-specific tropism for cell subtypes. We performed infections both in progenitor-derived astrocytes (HPDA) monitored infected cultures cytopathic effect (CPE), intra- extracellular DNA load, the presence of particles...
The growing use of Autonomous Agents (AAs) in both private and public sectors raises crucial questions about trust. As AI systems take on increasingly complex tasks decisions, their interactions with human agents (HAs) raise the relevance applicability traditional philosophical concepts trust trustworthiness (sections 1 2). In this paper, I will explore nuances AAs, arguing against complete dismissal as misplaced (section 4) application “genuine” frameworks 5). My aim is to lay groundwork...
Literature has suggested that changes in brain flow circulation occur patients with multiple sclerosis. In this study, digital subtraction angiography (DSA) was used to measure the absolute CCT value MS and correlate its age at disease onset duration, expand disability status scale (EDSS). DSA assessment performed on eighty a control group of forty-four age-matched patients. groups calculated by analyzing angiographic images. Lesion volumes were representative Statistical correlations among...
Abstract Membrane cofactor protein (CD46) is a regulator of complement activation that also serves as the entry receptor for human herpes virus 6 (HHV‐6) and measles (MV) into cells. While it clear oligodendrocytes astrocytes are cell types commonly infected by these viruses, unclear whether express CD46, or which cellular mechanisms underlying infection. We show adult oligodendrocytes, well microglial cells, CD46 on surface. Moreover, we employed quantitative fusion assay to demonstrate...
Abstract This is a paper about trust, with specific focus on the ways in which trust investigated business literature and commercial sector. The lens through topic approached distinctively philosophical. We use philosophical tools to demonstrate paucity of some accounts that are given management literature, as well empirically informed has flowed from them. close discussion work drawn sector would, we shall demonstrate, benefit clearer understanding nature trust. take this be important....
The ultrastructural replication cycle of human herpesvirus 6A and 6B, both T-lymphotropic viruses, with tropism for the central nervous system, was compared by electron microscopy in same cells, that is, T-lymphoblastoid cell line SupT-1 astrocytes. Both HHV-6A HHV-6B replicated efficiently formed viral particles. tegument is least characterized structure herpesviral particle variants were able to form intranuclear membrane compartments called tegusomes where tegumentation occurred. Also,...