A5063945140- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Cell death mechanisms and regulation
- Heat shock proteins research
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Viral Infectious Diseases and Gene Expression in Insects
- Endoplasmic Reticulum Stress and Disease
- Advanced Neuroimaging Techniques and Applications
- bioluminescence and chemiluminescence research
- Alzheimer's disease research and treatments
- Photochromic and Fluorescence Chemistry
- Neurogenesis and neuroplasticity mechanisms
- Microtubule and mitosis dynamics
- Retinal Diseases and Treatments
- Nerve injury and regeneration
- Insect Resistance and Genetics
- DNA Repair Mechanisms
- Advanced Proteomics Techniques and Applications
- Caveolin-1 and cellular processes
- Radiation Therapy and Dosimetry
- Virus-based gene therapy research
- Autism Spectrum Disorder Research
- Multiple Sclerosis Research Studies
- Cancer-related gene regulation
Centre for Cellular and Molecular Biology
2022
Macquarie University
2017-2020
Health and Human Development (2HD) Research Network
2018
Sankara Nethralaya
2016
Larsen & Toubro (India)
2016
The spread of neurodegeneration through the human brain network is reported as underlying progression neurodegenerative disorders. However, exact mechanisms remain unknown. visual pathway characterized by its unique hierarchical architecture and, therefore, represents an ideal model to study trans-synaptic degeneration, in contrast complexity neural connectivity whole brain. Here we show two specifically selected patient cohorts, including (i) glaucoma patients with symmetrical bilateral...
Amyloid β (Aβ) accumulation and its aggregation is characteristic molecular feature of the development Alzheimer's disease (AD). More recently, Aβ has been suggested to be associated with retinal pathology AD, glaucoma drusen deposits in age related macular degeneration (AMD). In this study, we investigated proteins biochemical networks that are affected by amyloid 661W photoreceptor cells culture. Time dose dependent effects on were determined utilising tandem mass tag (TMT) labelling-based...
Abstract The Hsp90 chaperone has become the attractive pharmacological target to inhibit tumor cell proliferation. However, cells can evolve with mechanisms overcome inhibition. Using human neuroblastoma, we have investigated one such limitation. Here, demonstrate that neuroblastoma interference of suppressor p16 INK4a in proliferation, which is due its latent interaction CDK4 and CDK6. Cells also displayed impedance inhibition cancer respect induced cytotoxicity. knockdown triggered...
Purpose Variations in Caveolin1/2 (Cav1/2) gene loci has been identified a risk factor glaucoma. Cav-1 is the prominent signature protein of caveola and implicated various signal transduction pathways. ablation previously shown to impair retinal function our study established that it involved regulation BDNF/TrkB signalling ganglion cells. This aimed investigate role specifically inner retina both healthy experimental glaucoma conditions. Methods Cav-1−/− age matched wildtype mice were used...