A5101984654- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Advancements in Battery Materials
- Advanced battery technologies research
- Retinal Development and Disorders
- Advanced Battery Materials and Technologies
- Advanced Battery Technologies Research
- Advanced Proteomics Techniques and Applications
- S100 Proteins and Annexins
- Mass Spectrometry Techniques and Applications
- Supercapacitor Materials and Fabrication
- Cholinesterase and Neurodegenerative Diseases
- Fuel Cells and Related Materials
- Metabolomics and Mass Spectrometry Studies
- Electrocatalysts for Energy Conversion
- Lymphoma Diagnosis and Treatment
- Complement system in diseases
- Tryptophan and brain disorders
- Thyroid Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Structure and Function
- Quinazolinone synthesis and applications
- Metabolism, Diabetes, and Cancer
- thermodynamics and calorimetric analyses
Sun Yat-sen University
2010-2025
Weatherford College
2024
Guangzhou Medical University
2024
First Affiliated Hospital of Guangdong Pharmaceutical University
2024
Macquarie University
2017-2023
Australian Genome Research Facility
2019
Deakin University
2019
Southern Medical University
2012
Sun Yat-sen University Cancer Center
2010
Glaucoma is a chronic disease that shares many similarities with other neurodegenerative disorders of the central nervous system. This study was designed to evaluate association between glaucoma and by investigating glaucoma-associated protein changes in retina vitreous humour. The multiplexed Tandem Mass Tag based proteomics (TMT-MS3) carried out on retinal tissue humour fluid collected from patients age-matched controls followed functional pathway network interaction analysis. About 5000...
Bipolar membrane (BPM)-based hybrid acid/alkali electrolyzers represent a notable advancement in the efficient production of hydrogen. However, degradation behaviors BPMs within systems are not well understood. This study introduces urea oxidation reaction (UOR) as an alternative to sluggish oxygen evolution at anode and utilizes X-ray computed tomography assess BPMs. Contrary conventional belief that anion exchange layer is less stable alkaline environments, it has been discovered BPM...
Amyloid β (Aβ) accumulation and its aggregation is characteristic molecular feature of the development Alzheimer's disease (AD). More recently, Aβ has been suggested to be associated with retinal pathology AD, glaucoma drusen deposits in age related macular degeneration (AMD). In this study, we investigated proteins biochemical networks that are affected by amyloid 661W photoreceptor cells culture. Time dose dependent effects on were determined utilising tandem mass tag (TMT) labelling-based...
Current evidence suggests that exposure to chronically induced intraocular pressure (IOP) leads neurodegenerative changes in the inner retina. This study aimed determine retinal proteomic alterations a rat model of glaucoma and compared findings with human proteomics reported previously. We developed an experimental by subjecting rats increased IOP (9.3 ± 0.1 vs 20.8 1.6 mm Hg) weekly microbead injections into eye (8 weeks). The tissues were harvested from control glaucomatous eyes protein...
Chronic inflammation has increasingly been acknowledged as a hallmark feature of several progressive neurodegenerative disorders. Accruing evidence indicates that sustained compromises the core neuroprotective mechanisms underlying neural injury in Alzheimer's disease (AD) and retinal Innate immunity activation classical complement pathways are suggested to play important roles normal central nervous system physiology complex tissue remodeling during process (Gasque et al., 2000). The...
Extracellular deposits of the amyloid-beta peptide (Aβ) are known as main pathological hallmark Alzheimer's disease. In disease, neurons injured and die throughout brain, a process in which Aβ neurotoxicity is considered to play an important role. However, molecular mechanisms underlying toxicity that lead neurodegeneration not clearly established. Here we have elucidated pathways networks impacted by using SH-SY5Y human neuroblastoma cells model. These were treated with Aβ1–42 peptides...
Photoreceptor cells are highly susceptible to oxidative-stress-induced damage due their high metabolic rate. Oxidative stress plays a key role in driving pathological events several different ocular diseases, which lead retinal degeneration and ultimately blindness. A growing number of studies have been performed understand downstream caused by ROS induced oxidative photoreceptor cells; however, the underlying mechanisms toxicity not fully understood. To shed light on events, we employed...
<title>Abstract</title> All solid-state lithium-ion batteries (ASSBs) are emerging as promising candidates for power applications in electric vehicles and various energy storage systems, garnering significant research interest. However, enhancing the Li<sup>+</sup> conductivity solid polymer electrolyte (SPE) stability have been persistent challenges field. This work demonstrates a novel approach to fabricating composite SPE with uniformly dispersed porous MOF-808 particles poly(ethylene...
The safety and pharmacokinetics assessment of antibodies targeting CD22 (e.g., epratuzumab) have been established in western Caucasian populations, but there are no reports the effects Chinese populations. This dose-escalation study examines safety, biologic multiple doses anti-CD22 human-murine chimeric monoclonal antibody SM03 21 patients with CD22-positive non-Hodgkin lymphoma. Most drug-related adverse events (AEs) were mild reversible. Two experienced serious AEs (hemorrhage); one...
Abstract Different parts of the brain are affected distinctively in various stages Alzheimer's disease (AD) pathogenesis. Identifying biochemical changes specific regions is key to comprehend neuropathological mechanisms early pre‐symptomatic phases AD. Quantitative proteomics profiling four distinct areas young APP/PS1 mouse model AD was performed followed by pathway enrichment analysis. Findings revealed fundamental compositional and functional shifts even disease. This novel study...
The use of a bipolar membrane (BPM) in hybrid acid/alkali electrolyzer is widely considered as promising energy technology for efficient hydrogen production. stability BPM often believed to be largely limited by the anion exchange layer (AEL) due hydrophilic attack AEL polymers hydroxide groups alkaline. In this study, we employ X-ray computed tomography (CT) investigate degradation behaviors and found that cation (CEL) experiences more pronounced compared with during water splitting...
ABSTRACT Proteomics, as a high-throughput technology, has been developed with the aim of investigating maximum number proteins in cells. However, protein discovery and data generation vary depth coverage when different technical strategies are used. In this study, four sample preparation, peptide or fractionation, methods were applied to identify quantify from log-phase yeast lysate: sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE); gas phase fractionation (GPF);...