A5053365890- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Aortic Disease and Treatment Approaches
- Infectious Aortic and Vascular Conditions
Medical University of South Carolina
2021-2023
Elevated interleukin-6 (IL-6) plasma levels have been associated with abdominal aortic aneurysm (AAA), but whether this cytokine plays a causative role in the degenerative remodeling or represents an effect from inflammatory cascades initiated by infiltrating leukocytes remained unclear. This project aims to demonstrate that within wall, signaling IL-6 through STAT3 transcription factor is necessary for infiltration of proteolytically-active macrophages and development small AAA.Following...
The angiotensin II type 1 receptor (AT1R) can be activated under conditions of mechanical stretch in some cellular systems. Whether this activity influences signaling within the abdominal aorta to promote aortic aneurysm (AAA) development remains unknown. We evaluated hypothesis that AT1R activation occur hypertension (HTN) and contribute AAA formation.BPH/2 mice, which demonstrate spontaneous neurogenic, low-renin HTN, normotensive BPN/3 mice underwent induction via calcium chloride model,...
Introduction: Serum biomarkers for abdominal aortic aneurysms (AAA) have been identified, but the prognostic relevance has remained unclear. Mechanical activation of VSMCs can elicit production interleukin-6 (IL-6), a cytokine consistently elevated in AAA. Expecting that stressed native cells may drive degenerative remodeling, we hypothesize focused on matrix proteolysis be elaborated directly from wall and assessed as an indicator strain. Methods: AAA was induced C57Bl/6 mice with...