A5005105671- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Aquaculture disease management and microbiota
- Respiratory viral infections research
- Pancreatic and Hepatic Oncology Research
- Viral Infections and Vectors
- T-cell and B-cell Immunology
- Virology and Viral Diseases
- Antimicrobial Resistance in Staphylococcus
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Microbial infections and disease research
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Streptococcal Infections and Treatments
- Plant Pathogenic Bacteria Studies
- Immune cells in cancer
- Rabies epidemiology and control
- Herpesvirus Infections and Treatments
- Adipose Tissue and Metabolism
- Fatty Acid Research and Health
University of Nebraska Medical Center
2020-2024
Nebraska Medical Center
2023
National Animal Disease Center
2013-2021
Oak Ridge Associated Universities
2021
Oak Ridge Institute for Science and Education
2021
Agricultural Research Service
2015-2020
Iowa State University
2015-2018
United States Department of Agriculture
2015-2018
Leipzig University
2000
ABSTRACT Parainfluenza viruses are known to inhibit type I interferon (IFN) production; however, there is a lack of information regarding the III IFN response during infection. Type IFNs signal through unique heterodimeric receptor, IFN-λR1/interleukin-10R2 (IL-10R2), which primarily expressed by epithelial cells. virus 3 (PIV-3) infection highly restricted airway epithelium. We therefore sought examine signaling pathways PIV-3 used three strains PIV-3: human (HPIV-3), bovine (BPIV-3), and...
Glaesserella ( Haemophilus ) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also causative agent Glässer’s disease, which causes significant morbidity mortality worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, has shown correlation with isolate pathogenicity. To investigate role capsule plays G. virulence host interaction, mutant serovar 5 strain HS069 was generated (HS069Δcap) through allelic exchange following natural...
Both veterinarians caring for dolphins in managed populations and researchers monitoring wild use blood-based diagnostics to monitor bottlenose dolphin (Tursiops truncatus) health. Quantitative PCR (qPCR) can be used assess cytokine transcription patterns of peripheral blood mononuclear cells (PBMC). This supplement currently available tests with information on immune status. Full realization this potential requires establishment normal ranges gene levels dolphins. We surveyed four over the...
Monitoring the immune status of cetaceans is important for a variety health conditions. Assays to quantify cytokines, especially pro-inflammatory could be employed, in addition currently available diagnostic assays, screen alterations an animal. Though number immunological assays are readily humans and mice, specific many veterinary species, including such as bottlenose dolphins (Tursiops truncatus), more limited. Herein, we describe development IFN-gamma (IFN-γ) TNF-alpha (TNF-α)...
ABSTRACT Staphylococcus aureus is part of the nasal microbiome many humans and has become a significant public health burden due to infections with antibiotic-resistant strains, including methicillin-resistant S. (MRSA) strains. Several lineages , MRSA, are found in livestock species can be acquired by through contact animals. These livestock-associated MRSA (LA-MRSA) isolates raise concerns because potential for act as reservoirs outside hospital setting. In United States, swine harbor...
Chronic inflammation has been associated with insulin resistance and type 2 diabetes (T2D) in humans. Postmortem hepatic splenic tissue from a 46-year-old geriatric male bottlenose dolphin (Tursiops truncatus) (chronic hyperinsulinemia hyperglycemia), chronic (white blood cell count greater than 12,000 cells/μL), mild fatty liver disease was evaluated for elevated pro-inflammatory mediators. Cytokine mRNA expression postmortem tissue, as determined by real-time PCR, included an array of...
Pancreatic ductal adenocarcinoma (PDAC) represents 3% of all cancer cases and 7% deaths in the United States. Late diagnosis inadequate response to standard chemotherapies contribute an unfavorable prognosis overall 5-year survival rate less than 10% PDAC. Despite recent advances tumor immunology, tumor-induced immunosuppression attenuates immunotherapy To date, studies have focused on IgG-based therapeutic strategies With interest IgE-based therapies multiple solid tumors, we explored...
<p>Amino acid sequence of anti-MUC1.IgE antibody</p>
<p>Amino acid sequence of anti-MUC1.IgE antibody</p>
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) represents 3% of all cancer cases and 7% deaths in the United States. Late diagnosis inadequate response to standard chemotherapies contribute an unfavorable prognosis overall 5-year survival rate less than 10% PDAC. Despite recent advances tumor immunology, tumor-induced immunosuppression attenuates immunotherapy To date, studies have focused on IgG-based therapeutic strategies With interest IgE-based therapies multiple...
<p>Gating strategy for immune subsets in pancreatic tumor</p>
<p>Gating strategy for immune subsets in pancreatic tumor</p>
<div>Abstract<p>Pancreatic ductal adenocarcinoma (PDAC) represents 3% of all cancer cases and 7% deaths in the United States. Late diagnosis inadequate response to standard chemotherapies contribute an unfavorable prognosis overall 5-year survival rate less than 10% PDAC. Despite recent advances tumor immunology, tumor-induced immunosuppression attenuates immunotherapy To date, studies have focused on IgG-based therapeutic strategies With interest IgE-based therapies multiple...
e14577 Background: Social media (SM) could transform how individuals learn of clinical trials. In an ongoing, single-center cohort study to collect serial biospecimens and data from high-risk (HRIs) for pancreatic cancer (PC), we explored HRIs learned the study, surveyed relevant SM posts compared those referred by vs. other means. Methods: Initial recruitment focused on with familial risk PC. Referral method was self-reported. We identified via means ANOVA t-test. Investigators did not...
<h3>Background</h3> Pancreatic Ductal Adenocarcinoma (PDAC) is bad. An immunosuppressive tumor microenvironment (TME) with an excess of immune cells and cytokine/chemokine factors contribute to local systemic immunosuppression in PDAC.<sup>1</sup> Our laboratory has generated single-cell RNA-Sequencing (scRNA-Seq.) data from spleens derived PDAC patients healthy counterparts. This demonstrates the existence dendritic cell (DC) subsets a tolerogenic phenotype. These DCs display increased...