A5013763511- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- COVID-19 Clinical Research Studies
- Nuclear Structure and Function
- COVID-19 and healthcare impacts
- RNA Research and Splicing
- Glioma Diagnosis and Treatment
- Innovations in Medical Education
- Epigenetics and DNA Methylation
- Eosinophilic Disorders and Syndromes
- Radiology practices and education
- Cytokine Signaling Pathways and Interactions
- Radiomics and Machine Learning in Medical Imaging
- Kruppel-like factors research
- Mycobacterium research and diagnosis
- Diabetes and associated disorders
- Central Venous Catheters and Hemodialysis
- Chronic Lymphocytic Leukemia Research
- Global Health Workforce Issues
- Ultrasound in Clinical Applications
- Research on Leishmaniasis Studies
- RNA regulation and disease
- Radiation Dose and Imaging
- Ophthalmology and Visual Health Research
Cornell University
2015-2025
Weill Cornell Medicine
2020-2025
Presbyterian Hospital
2019-2024
New York Hospital Queens
2021-2024
NewYork–Presbyterian Hospital
2021-2024
Memorial Sloan Kettering Cancer Center
2013-2023
Kettering University
2015-2023
Tri-Institutional PhD Program in Chemical Biology
2013-2023
Massachusetts General Hospital
2023
Montefiore Medical Center
2022-2023
Abstract The identification of JAK2/MPL mutations in patients with myeloproliferative neoplasms (MPN) has led to the clinical development JAK kinase inhibitors, including ruxolitinib. Ruxolitinib reduces splenomegaly and systemic symptoms myelofibrosis improves overall survival; however, mechanism by which inhibitors achieve efficacy not been delineated. Patients MPN present increased levels circulating proinflammatory cytokines, are mitigated inhibitor therapy. We sought elucidate...
Significance Myeloproliferative neoplasms (MPN) are chronic hematopoietic disorders characterized by clonal proliferation of mature myeloid elements. A subset MPNs transforms to acute leukemia (AML). The mechanisms and pathways that contribute transformation from MPN AML have not been well delineated. We the somatic mutational spectrum post-MPN demonstrate tumor protein 53 ( TP53 ) mutations common in JAK2 V617F - mutant, but chronic-phase MPN. expression combined with Tp53 loss a murine...
Although clinically tested JAK inhibitors reduce splenomegaly and systemic symptoms, molecular responses are not observed in most myeloproliferative neoplasm (MPN) patients. We previously demonstrated that MPN cells become persistent to type I bind the active conformation of JAK2. investigated whether CHZ868, a II inhibitor, would demonstrate activity inhibitor cells, murine models, patient samples. JAK2 MPL mutant cell lines were sensitive including cells. CHZ868 showed significant models...
Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated poor outcomes. Here, we showed that combined expression of Jak2V617F mutant IDH1R132H Idh2R140Q induces MPN progression, alters stem/progenitor cell function, impairs differentiation mice. Idh2R140Q–mutant MPNs were sensitive small-molecule inhibition IDH....
Nucleocytoplasmic transport occurs through the nuclear pore complex (NPC), which in yeast is a ~50 MDa consisting of ~30 different proteins. Small molecules can freely exchange NPC, but macromolecules larger than ~40 kDa must be aided across by factors, most belong to related family proteins termed karyopherins (Kaps). These factors bind disordered phenylalanine-glycine (FG) repeat domains NPC FG nups, and this specific binding allows cross NPC. However, we still know little terms molecular...
Abstract Background Melanoma brain metastases historically portend a dismal prognosis, but recent advances in immune checkpoint inhibitors (ICIs) have been associated with durable responses some patients. There are no validated imaging biomarkers outcomes patients melanoma receiving ICIs. We hypothesized that radiomic analysis of magnetic resonance images (MRIs) could identify higher-order features survival. Methods Between 2010 and 2019, we retrospectively reviewed who received ICI. After...
Abstract Background Despite increased risk of venous thromboembolism (VTE) among hospitalized patients with inflammatory bowel disease (IBD), pharmacologic prophylaxis rates remain low. We sought to understand the reasons for this by assessing factors associated VTE in IBD and safety its use. Methods This was a retrospective cohort study conducted between January 2013 August 2018. The primary outcome prophylaxis, exposures interest included acute chronic bleeding. Medical records were parsed...
Objective. To examine the effect of autoimmune (AI) disease on composite outcome intensive care unit (ICU) admission, intubation, or death from COVID-19 in hospitalized patients. Methods. Retrospective cohort study 186 patients with between March 1, 2020, and April 15, 2020 at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. The included 62 AI 124 age- sex-matched controls. primary was a ICU death, secondary as time to in-hospital death. Baseline demographics,...
Sarcopenia has been associated with adverse postoperative outcomes in older age cohorts, but not assessed adults inflammatory bowel disease (IBD). Further, current assessments of sarcopenia among all aged individuals IBD have used various measures muscle mass as well cutoffs to define its presence, leading heterogeneous findings.
Since 2009, a multidisciplinary team at Weill Cornell Medical College (WCMC) has collaborated to create comprehensive, elective global health curriculum (GHC) for medical students. Increasing student interest sparked the development of this program, which grown from ad hoc lectures and dispersed international electives into comprehensive four-year pathway with over 100 hours training, including three courses, two experiences, preceptorship clinician working underserved populations in New...
Pseudoprogression mimicking recurrent glioblastoma remains a diagnostic challenge that may adversely confound or delay appropriate treatment clinical trial enrollment. We sought to build radiomic classifier predict pseudoprogression in patients with primary isocitrate dehydrogenase wild type glioblastoma.We retrospectively examined training cohort of 74 glioblastomas brain magnetic resonance imaging including dynamic contrast enhanced T1 perfusion before resection an enhancing lesion...
A medical student perspective on the role of core competencies in undergraduate education light reform associated with recent Flexner II.