Cassidy C. Cobbs
A5085869657- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Genomics and Rare Diseases
- Neuroblastoma Research and Treatments
- Molecular Biology Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Space Exploration and Technology
- Insect-Plant Interactions and Control
- Pancreatic and Hepatic Oncology Research
- Plant and animal studies
- Plant biochemistry and biosynthesis
- Microfluidic and Capillary Electrophoresis Applications
- Radiomics and Machine Learning in Medical Imaging
- Nanopore and Nanochannel Transport Studies
- Planetary Science and Exploration
- Space Science and Extraterrestrial Life
Memorial Sloan Kettering Cancer Center
2022-2025
Igenbio (United States)
2022-2025
Kettering University
2023
Molecular Oncology (United States)
2022-2023
Vanderbilt University
2013
Abstract The utility of cancer whole genome and transcriptome sequencing (cWGTS) in oncology is increasingly recognized. However, implementation cWGTS challenged by the need to deliver results within clinically relevant timeframes, concerns about assay sensitivity, reporting prioritization findings. In a prospective research study we develop workflow that reports comprehensive 9 days. Comparison diagnostic panel assays demonstrates potential capture all reported mutations with comparable...
Abstract Multiple large-scale genomic profiling efforts have been undertaken in osteosarcoma to define the drivers of tumorigenesis, therapeutic response, and disease recurrence. The spatial temporal intratumor heterogeneity could also play a role promoting tumor growth treatment resistance. We conducted longitudinal whole-genome sequencing 37 samples from 8 patients with relapsed or refractory osteosarcoma. Each patient had at least one sample primary site metastatic relapse site. Subclonal...
Long-read DNA and RNA sequencing facilitate genome assembly, haplotyping, complex variant calling, gene isoform identification. Structural calling is integral to the molecular characterization of tumors; thus, long-read nanopore technology becoming routinely used in cancer research. As a standard practice, high weight (HMW) extracted from both tumor matched normal samples blood or buffy coat redact germline variants somatic mutations. However, we found that consistently underperformed...
Abstract Purpose: Therapy-related myelodysplastic syndrome and acute leukemias (t-MDS/AL) are a major cause of nonrelapse mortality among pediatric cancer survivors. Although the presence clonal hematopoiesis (CH) in adult patients at diagnosis has been implicated t-MDS/AL, there is limited published literature describing t-MDS/AL development children. Experimental Design: We performed molecular characterization 199 serial bone marrow samples from 52 treated for high-risk neuroblastoma,...
Multiple large-scale tumor genomic profiling efforts have been undertaken in osteosarcoma, however, little is known about the spatial and temporal intratumor heterogeneity how it may drive treatment resistance. We performed whole-genome sequencing of 37 samples from eight patients with relapsed or refractory osteosarcoma. Each patient had at least one sample a primary site metastatic relapse site. identified subclonal copy number alterations all but patient. observed that five patients,...
Supplementary Data from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
<div>AbstractPurpose:<p>Therapy-related myelodysplastic syndrome and acute leukemias (t-MDS/AL) are a major cause of nonrelapse mortality among pediatric cancer survivors. Although the presence clonal hematopoiesis (CH) in adult patients at diagnosis has been implicated t-MDS/AL, there is limited published literature describing t-MDS/AL development children.</p>Experimental Design:<p>We performed molecular characterization 199 serial bone marrow samples from 52...
<div>AbstractPurpose:<p>Therapy-related myelodysplastic syndrome and acute leukemias (t-MDS/AL) are a major cause of nonrelapse mortality among pediatric cancer survivors. Although the presence clonal hematopoiesis (CH) in adult patients at diagnosis has been implicated t-MDS/AL, there is limited published literature describing t-MDS/AL development children.</p>Experimental Design:<p>We performed molecular characterization 199 serial bone marrow samples from 52...
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Data from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
Supplementary Figure from Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia