A5101777928- Eicosanoids and Hypertension Pharmacology
- Multi-Criteria Decision Making
- Bioactive Natural Diterpenoids Research
- Fluoride Effects and Removal
- Optimization and Mathematical Programming
- Genomics and Rare Diseases
- Genetic and rare skin diseases.
- Dental Health and Care Utilization
- Dermatological and Skeletal Disorders
- Advanced Theoretical and Applied Studies in Material Sciences and Geometry
- Evaluation and Optimization Models
- Alcohol Consumption and Health Effects
- Electronic and Structural Properties of Oxides
- Plant-based Medicinal Research
- Food Quality and Safety Studies
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Carbon and Quantum Dots Applications
- Conducting polymers and applications
- Research, Science, and Academia
- Fuzzy Logic and Control Systems
- Advanced Photocatalysis Techniques
- Ferroelectric and Negative Capacitance Devices
- Phytochemistry and Biological Activities
- Diet, Metabolism, and Disease
Jiangsu Provincial Center for Disease Control and Prevention
2008-2025
Beijing University of Chinese Medicine
2020-2024
National Chung Cheng University
2023
Shanxi University
2022
National Taiwan University
2022
Nanjing Tech University
2022
China Academy of Information and Communications Technology
2021
National Ilan University
2021
Xi'an University of Technology
2005-2021
System Simulation (United Kingdom)
2021
The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs), which are highly abundant in the kidney and considered renoprotective. Accumulating evidence suggests that EETs important regulating renal cardiovascular function. Further, have been confirmed exert diverse biological activities including potent vasodilation; fibrinolytic properties; antiinflammatory, antiapoptotic, mitogenic effects. In current study, we investigated...
Ti/HfOx-based resistive random access memory (RRAM) has been extensively investigated as an emerging nonvolatile (NVM) candidate due to its excellent performance and CMOS process compatibility. Although the importance of role Ti buffer layer is well recognized, detailed understanding about nature thickness-dependent asymmetric switching still missing. To realize this, present work addresses effects thickness on properties TiN/Ti/HfOx/TiN 1T1R RRAM. Consequently, we have demonstrated a simple...
Cytochrome P-450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play important roles in regulating cardiovascular functions. The anti-inflammatory, antiapoptotic, proangiogenic, and antihypertensive properties of EETs suggest a beneficial role for diabetic nephropathy. Endogenous EET levels are maintained by balance between synthesis CYP hydrolysis epoxide hydrolases physiologically less active dihydroxyeicosatrienoic acids. Genetic disruption...
Cytochrome P-450 epoxygenase-derived epoxyeicosatrienoic acids (EETs) exert diverse biological activities, which include potent vasodilatory, anti-inflammatory, antiapoptotic, and antioxidatant effects, cardiovascular protection. Liver has abundant epoxygenase expression high levels of EET production; however, the roles epoxygenases in liver diseases remain to be elucidated. In this study, we investigated protection against high-fat diet-induced nonalcoholic fatty disease (NAFLD) mice with...
A facile rapid thermal annealing method to prepare FeOCl/iron hydroxide hybrid nanosheets is reported.
Abstract Macrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Previous studies demonstrated beneficial effects of epoxyeicosatrienoic acids (EETs) on disorders inflammation. Here we investigated CYP2J2-EETs-sEH pathway mice potential mechanisms. High fat diet (HFD)-induced obesity caused dysfunction more weight gain, elevated glucose lipids levels, impaired tolerance sensitivity,...
Long-term exposure to particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) are linked thyroid nodules in adults, but epidemiological evidence children and adolescents adjustments for key confounders lacking. This study aimed explore the association between long-term PM2.5 prevalence of school-aged adolescents. A cross-sectional including 10,739 primary junior high school students was conducted Jiangsu Province, China, 2021. Annual concentrations were estimated by a satellite based...
Objective The study aims to investigate the effect of cytochrome P450 2J2 (CYP2J2) overexpression on hyperlipidemia in mice and further explore its fatty acid oxidation vivo vitro. Methods effects mechanisms endothelial-specific CYP2J2 transgene (Tie2-CYP2J2-Tr) lipid metabolism were investigated high-fat diet (HFD) -treated mice. HepG2, LO2 cells, HUVECs exposed 0.4 mM free (FFA) for 24 h used as a model roles epoxyeicosatrienoic acids (EETs) β-oxidation Results Tie2-CYP2J2-Tr had...
Catalytic performance of Pt based nanocatalysts significantly depends on their morphologies, compositions and structures. In this work, the generation-4 phenylazomethine-tetraphenylmethane dendrimer (TPMG4)-encapsulated PtSn bimetallic ultrafine nanoparticles with tunable ratio Sn (PtnSn60-n@TPMG4/GMC, n = 56, 48, 32) supported graphitic mesoporous carbon (GMC) were fabricated through co-reduction method by using phenylazomethine as a template. The compositions, structures resulting...
Abstract Rare skin diseases include more than 800 affecting 6.8 million patients worldwide. However, only 100 drugs have been developed for treating rare in the past 38 years. To investigate potential treatments through drug repurposing diseases, it is necessary to a well-organized database link all known disease causes, mechanisms, and related information accelerate process. Drug provides less expensive faster options develop diseases. In this work, we designed constructed (RSDB) as...
To explore the management of lymphatic malformation in head and neck.
A novel biodegradable super absorbent polymer (SAP) was synthesized by γ-poly (glutamic acid) (γ-PGA) and poly (ethylene glycol) with the units of glycidyl ether as chain ends (PEGGE). The resultant γ-PGA SAPs different PEGGE contents were characterized their effects on soil total available water (TAW) investigated. SAP at 45 °C for 48 h when 160 g L−1 (pH = 4.9) minimum mass 20% mass. When increased from to 60%, absorption rate (WAR) in distilled 0.9% NaCl solution gradually decreased...
Semen Euphorbiae (SE), the dry and mature seed of Euphorbia lathyris L., a common traditional Chinese medicine, has significant pharmacological activity. However, its toxicity limits clinical application, less toxic Pulveratum (SEP) is often used clinically. To explore possible mechanism SE frost-making attenuation, this study ultrahigh-performance liquid chromatography coupled with quadrupole time flight mass spectrometry to perform comprehensive metabolomics analysis serum urine samples...
Abstract: Anatase and its allomorphic mineral rutile have the most prominent economic significance among titanium resources constitute one of badly needed currently in China. The Yantizishan‐Moshishan anatase deposit was formerly referred to as an iron Based on recent investigation exploration authors believe that it is actually a large metamorphosed sedimentary anatase‐dominated belonging new genetic type. Ore bodies occur stratoid lenticular forms Mesoproterozoic (1751 Ma) schist,...
Multilayer ZnO sheet-like flakes were synthesized by a simple method of precipitation and characterized the techniques X-Ray Diffraction (XRD) Scanning Electron Microscopy (SEM). The findings are proven that SEM images show overall morphology single nanostructure made from uniformly thick nano-sheets. In an aqueous environment, acoustic ability prepared material was assessed using ultrasound (US) radiation to degrade oxytetracycline (OTC) norfloxacin (NF). To increase degradation efficiency,...