A5101932911- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Asymmetric Synthesis and Catalysis
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Retinal Diseases and Treatments
- Marine Sponges and Natural Products
- Synthesis and Catalytic Reactions
- Glaucoma and retinal disorders
- Asymmetric Hydrogenation and Catalysis
- Alkaloids: synthesis and pharmacology
- Natural product bioactivities and synthesis
- Bone health and osteoporosis research
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Metabolomics and Mass Spectrometry Studies
- Synthesis and Biological Activity
- Phytochemistry and Biological Activities
- Microbial Natural Products and Biosynthesis
- Carbohydrate Chemistry and Synthesis
- Ocular Surface and Contact Lens
- Genomics, phytochemicals, and oxidative stress
Asia University
2011-2024
Fu Jen Catholic University
2021-2024
National Taiwan University
2022-2024
Asia University
2021-2023
Kaohsiung Medical University
2010
National Chung Hsing University
2003-2007
Institute of Chemistry, Academia Sinica
2006
Atropine and orthokeratology (OK) are both effective in slowing the progression of myopia. In current study, we studied combined effects atropine OK lenses on This retrospective study included 84 patients who wore received treatment (OA) 95 alone for 2 years. We stratified into low (<6 D, LM) high (≥6 HM) myopia groups, as well two different concentrations (0.125% 0.025%). Significantly better LM control was observed OA1 patients, compared with OK1 patients. Axial length significantly...
Human breast cancers cells overexpressing HER2/neu are more aggressive tumors with poor prognosis, and resistance to chemotherapy. This study investigates antiproliferation effects of anthraquinone derivatives rhubarb root on human cancer cells. Of 7 derivatives, only rhein showed antiproliferative apoptotic both HER2-overexpressing MCF-7 (MCF-7/HER2) control vector (MCF-7/VEC) Rhein induced dose- time-dependent manners increase in caspase-9-mediated apoptosis correlating activation...
This study rated antiviral activity of Scutellaria baicalensis Georgi (S. baicalensis) extracts against influenza A virus subtypes, for example, pandemic 2009 H1N1, seasonal H1N1 and H3N2. Ethyl acetate (EtOAc) chloroform inhibited in vitro neuraminidase (NA) enzymatic viral replication more than methanol (MeOH) extract. EtOAc extract demonstrated NA inhibition IC50 values ranging from 73.16 to 487.40 μg/mL plaque reduction 23.7 27.4 μg/mL. Chloroform showed activities with 14.16 41.49...
Abstract Background The increased global incidence of myopia requires the establishment therapeutic approaches. This study aimed to investigate effect Fallopia Japonica (FJ) and Prunella vulgaris (PV) extract on caused by monocular form deprivation (MFD). Methods We used human retinal pigment epithelial cell molecular mechanisms how FJ (FJE) PV (PVE) lowering inflammation eye. FJE PVE in MFD induced hamster model explore role cytokines myopia. Results + reduced IL-6, IL-8, TNF-α expression...
Scope The aim of this study is to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and efficacy AITC in suppressing galectin‐12 levels as a therapeutic for high fat diet (HFD)‐induced obesity. Methods results presents anti‐adipogenic effects on 3T3‐L1 cells decreasing lipid droplet accumulation dose‐dependent manner. suppresses into adipocytes expression downregulating key adipogenic transcription factors. influences pre‐adipocytes...
Abstract To investigate the particle size distribution of particulate matter and concentration specific perfluorinated compounds in indoor dust samples from several locations. Then, we used cell-based assays to effect on human corneal epithelial (HCEpiC), endothelial cells (HCEC) retinal pigment (RPE). Indoor were collected at five different locations PM 50–10 , 10–2.5 2.5–1 fractionized. The presence levels 8:2 fluorotelomer alcohol, 10:2 perfluorooctanoic acid detected by gas...
Myopia is a highly prevalent refractive disorder. We investigated the effect of diacerein on monocular form deprivation (MFD) in hamsters as possible therapeutic intervention. Diacerein an anthraquinone derivative drug whose active metabolite rhein. or atropine was applied to MFD hamsters, and their error axial length were measured after 21 days. The (control: -0.91 ± 0.023, atropine: -0.3 0.08, diacerein: -0.27 0.07 D) 0.401 0.017, 0.326 0.334 0.016 mm) showed statistically significant...
Abstract Rare skin diseases include more than 800 affecting 6.8 million patients worldwide. However, only 100 drugs have been developed for treating rare in the past 38 years. To investigate potential treatments through drug repurposing diseases, it is necessary to a well-organized database link all known disease causes, mechanisms, and related information accelerate process. Drug provides less expensive faster options develop diseases. In this work, we designed constructed (RSDB) as...
Background: Dopamine has been suggested to be a stop signal for eye growth and affects the development of myopia. Acupuncture is known increase dopamine secretion widely used treat myopia clinically. Objective: The aim this study was determine if acupuncture inhibits progression in form deprived Syrian hamsters by inducing rises content that turn suppress inflammasome activation. Methods: applied at LI4 Taiyang every other day 21 days. levels molecules associated with signaling pathway,...
A simple and rapid chelating‐resin‐packed column has been developed for preconcentration of trace indium in biological samples. large‐sized urine sample was pumped through a minicolumn at flow rate 1.0 mL/min by using peristaltic pump, the eluents were analyzed graphite furnace atomic absorption spectrometry ( GFAAS ). Four commercially available chelating resins including C helex‐100, mberlite IRC ‐50, D uolite GT ‐73, elite 545‐ AW studied evaluating sorption performance. Several...
An easy and straightforward synthesis of 6,10b-diarylhexahydrobenzo[f]isoquinoline by the repeated treatment boron trifluoride etherate (BF(3) x OEt(2)) is reported. The overall transformation from 4-arylpiperidin-3-one to benzo[f]isoquinoline proceeds via ring contraction, chain elongation, intramolecular electrophilic cyclization in moderate yields. It presents a novel rearrangement reaction catalyzed broadens scope application.
The formation of foam cells, which are macrophages that have engulfed oxidized low-density lipoprotein (OxLDL), constitutes the first stage in development atherosclerosis. Previously, we found knocking down galectin-12, a negative regulator lipolysis, leads to reduced secretion monocyte chemoattractant protein-1 (MCP-1), chemokine plays an important role This prompted us study galectin-12 With aim, examined cell Gal12‒/‒ murine exposed OxLDL and acetylated LDL (AcLDL). Then, generated...
A formal enantioselective synthesis of benazepril.HCl (4), an anti- hypertensive drug, is reported. Our employed asymmetric aza-Michael addition L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo- but-2-enoic acid methyl (6) as the key step prepare (2S,3'S)-2-(2-oxo-2,3,4,5- tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric (8), which intermediate leading benazepril x HCl (4).
Introduction: Vitamin D plays a vital role in maintaining homeostasis and enhancing the absorption of calcium, an essential component for strengthening bones preventing osteoporosis. There are many factors known to relate plasma vitamin concentration (PVDC). However, most these studies were performed with traditional statistical methods. Nowadays, machine learning methods (Mach-L) have become new tools medical research. In present study, we used four Mach-L explore relationships between PVDC...
The first total synthesis of louisianin A, 4-allyl-6,7-dihydro-1-hydroxycyclopenta[c]pyridin-5-one, is achieved from 2-chloro-4-cyanopyridine 5 via seven steps in an overall 24% yield. key step a cyclization−decarboxylation sequence toward the formation cyclopentenone ring.