A5101850981- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Erythrocyte Function and Pathophysiology
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Air Quality and Health Impacts
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Diabetes and associated disorders
- Phytochemistry and biological activity of medicinal plants
- Pharmacological Effects of Natural Compounds
- Pancreatic function and diabetes
- Acupuncture Treatment Research Studies
- Blood groups and transfusion
- Phytochemistry and Biological Activities
- Retinoids in leukemia and cellular processes
- Immune Cell Function and Interaction
- Facial Rejuvenation and Surgery Techniques
- Flavonoids in Medical Research
- Galectins and Cancer Biology
China Medical University Hospital
2015-2025
China Medical University
2015-2025
Mackay Memorial Hospital
2015-2021
China Medical University
2019-2021
University of California, Davis
2018
National Science and Technology Council
2016
Hualien Tzu Chi Medical Center
2008
Pennsylvania State University
2008
Tunghai University
2003-2005
Atropine and orthokeratology (OK) are both effective in slowing the progression of myopia. In current study, we studied combined effects atropine OK lenses on This retrospective study included 84 patients who wore received treatment (OA) 95 alone for 2 years. We stratified into low (<6 D, LM) high (≥6 HM) myopia groups, as well two different concentrations (0.125% 0.025%). Significantly better LM control was observed OA1 patients, compared with OK1 patients. Axial length significantly...
Background Hyperinflammation with dysregulated production of galectins and cytokines may develop in COVID-19 or adult-onset Still’s disease (AOSD). Given the similar clinical features both diseases, it is necessary to identify biomarkers that can differentiate from AOSD. However, related data remain scarce currently. Methods In this cross-sectional study, plasma levels galectin-3, galectin-9, soluble TIM-3 (sTIM-3) were determined by ELISA 55 patients (31 non-severe 24 severe), 23 active...
We reported a case of sudden monocular vision loss after calcium hydroxyapatite (CaHA) injection into the nasal tip and dorsum with detailed retina images.A healthy, 35-year-old woman received CaHA filler for nose augmentation. Ten minutes procedure, she developed nausea, vomiting, headache, ptosis, left periorbital pain. After 30 minutes, complained progressively blurring in eye. The best-corrected visual acuity (BCVA) her eye was cm ahead hand motion. Left exotropia noted primary gaze....
Abstract Background Poly-D, L-lactic acid is (PDLLA) a new cosmetic filler. We reported the first case of PDLLA-related devastating complication multiple branch retinal artery occlusion (BRAO). Case presentation A 23-year-old female had sudden blindness after injection PDLLA at glabella. After emergency intraocular pressure-lowering medicine, ocular massage, steroid pulse therapy, heparin and alprostadil infusion, subsequent treatments including acupuncture 40 sessions hyperbaric oxygen her...
Abstract Aloe‐emodin, a natural polyphenolic anthraquinone, has shown various beneficial bioactivities in vitro . The aim of this study was to investigate the pharmacokinetics and metabolism aloe‐emodin. Aloe‐emodin intravenously orally administered rats. concentrations aloe‐emodin rhein, metabolite aloe‐emodin, were determined by HPLC method prior after hydrolysis with β ‐glucuronidase sulfatase/ ‐glucuronidase. results showed that systemic exposures its metabolites ranked as glucuronides...
Diabetic retinopathy (DR) is a leading cause of vision loss among adults. This study evaluates Optical Coherence Tomography Angiography (OCTA) vessel density (VD) as marker for DR in diabetes mellitus (DM) patients. An observational was conducted with 47 type 2 DM patients and 21 healthy controls. OCTA measured superficial deep retinal VD the parafoveal region. Statistical analyses, including logistic regression ROC curve analysis, were used to assess association between presence. Results...
To evaluate whether glucagon-like peptide-1 receptor agonists (GLP-1RAs) are associated with reduced retinal vein occlusion (RVO) risk compared dipeptidyl peptidase-4 (DPP-4) inhibitors in patients type 2 diabetes mellitus (T2DM). A multinational, retrospective cohort study. Adults T2DM newly prescribed GLP-1RAs or DPP-4 between 2006 and 2023 were included our analysis. This study leveraged data from populations across 21 countries. Propensity score matching at a 1:1 ratio balanced age, sex,...
Abstract Background/Objectives This study investigated the impact of dopaminergic medications on myopia progression by comparing susceptibility in ADHD patients treated with agents to those untreated. A non-ADHD cohort was also established assess risk compared individuals ADHD. Subjects/Methods population-based used Taiwan National Health Insurance data (2009–2020), stratifying participants status. Myopia identified using ICD-10 diagnostic codes, while ADHD-related drug usage...
To compare the impact of sodium-glucose cotransporter 2 (SGLT2) and dipeptidyl peptidase 4 (DPP-4) inhibitors on age-related macular degeneration (AMD) risk among patients with type diabetes mellitus (T2DM). This multinational, retrospective cohort study used electronic medical records from healthcare institutions across 21 countries. Adults 50 years or older T2DM who had a prior prescription metformin initiated SGLT2 DPP-4 2013 to 2023 were included. The inhibitor groups propensity score...
We addressed the underrepresentation of non-European populations in genome-wide association studies (GWASs) by building HiGenome, a large-scale genetic resource for Taiwanese Han population. Using custom genotyping array, we integrated deidentified electronic medical records (2003 to 2021) with genomic data enable GWASs, phenome-wide studies, and polygenic risk score (PRS) analysis. Among 413,000 participants, 323,397 passed ancestry quality control filtering. GWASs covered 1085 traits,...
Abstract Loss of eye growth regulation may cause myopia, because modulation optic globe size is essential for the generation normal power. Evidence has implied variations BMP2 gene expression mediate ocular development and retinal tissue remodeling. Given as a potential regulator involved in myopia development, we investigate whether BMP2‐inducible kinase (BMP2K, BIKe), whose up‐regulated during BMP2‐induced osteoblast differentiation, contributes to susceptibility high myopia. Participants...
The traditional way to detect visual fatigue is use the questionnaire or critical fusion frequency of high-frequency exchanges due eye fatigue. objective this study was explore whether movement behavior can be used as an tool Thirty-three participants were tested in study. Their subjective survey, frequency, and tracker one minute gaze measured before after 20 minutes task. There significant differences task on survey tracker-derived features. By multiple regression analysis with four...
Abstract Background The increased global incidence of myopia requires the establishment therapeutic approaches. This study aimed to investigate effect Fallopia Japonica (FJ) and Prunella vulgaris (PV) extract on caused by monocular form deprivation (MFD). Methods We used human retinal pigment epithelial cell molecular mechanisms how FJ (FJE) PV (PVE) lowering inflammation eye. FJE PVE in MFD induced hamster model explore role cytokines myopia. Results + reduced IL-6, IL-8, TNF-α expression...