A5100783317- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Prostate Cancer Diagnosis and Treatment
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Urological Disorders and Treatments
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Molecular Biology Techniques and Applications
- Gynecological conditions and treatments
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Aortic aneurysm repair treatments
- MicroRNA in disease regulation
- Cardiac Valve Diseases and Treatments
- Selenium in Biological Systems
- Gastric Cancer Management and Outcomes
- Aortic Disease and Treatment Approaches
- Bone health and treatments
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Gene expression and cancer classification
University of Warwick
2023-2025
AstraZeneca (United States)
2025
SUNY Upstate Medical University
2024
AstraZeneca (Japan)
2023
Cancer Society of New Zealand
2012-2022
University of Auckland
2015-2022
AbbVie (United States)
2017-2021
The Ocean Cleanup
2021
University of Kansas
2020
Nashville Oncology Associates
2018
Abstract Biological processes, such as growth control, are often governed by biochemical steps involving mRNA transcripts that short‐lived and have a low copy number. Furthermore, the cells involved in these processes available numbers from vivo sources. We now report method is superior to situ hybridization, RNA blot analysis, nuclease protection assay for study of short‐lived, low‐copy‐number transcripts. The consists microprocedure isolating one few thousand two coupled enzymatic steps:...
Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and associated with substantial morbidity for the mother fetus. Enhanced vasoconstrictor elevations soluble fms-like tyrosine kinase 1 (sFLT1), circulating antiangiogenic protein, precede clinical signs symptoms preeclampsia. Here, we report that overexpression sFlt1 pregnant mice induced II hypertension by impairing endothelial nitric oxide synthase...
Androgen deprivation therapy (ADT) administered as a prostate cancer treatment is known to exert multiple side effects including bone deterioration leading fracture. The current analysis evaluate the burden of fracture risk in New Zealand (PCa) population treated with ADT, and understand subsequent mortality after Using datasets created through linking records from Cancer Registry, National Minimal Dataset, Pharmaceutical Collection Mortality Collection, we studied 25,544 men (aged ≥40...
To investigate the safety and efficacy of elagolix, an oral gonadotropin-releasing hormone antagonist, with hormonal add-back therapy for up to 12 months in women heavy menstrual bleeding associated uterine leiomyomas.Elaris UF-EXTEND was a phase 3 extension study that evaluated additional 6 (up total) elagolix 300 mg twice daily (estradiol 1 norethindrone acetate 0.5 once daily) who completed initial same treatment one two preceding studies. The primary endpoint percentage both less than 80...
Abstract Alzheimer’s disease (AD) and other tauopathies are characterized by the aggregation of tau into soluble insoluble forms (including tangles neuropil threads). In humans, a fraction both phosphorylated non-phosphorylated N-terminal to mid-domain species, secreted cerebrospinal fluid (CSF). Some these CSF species can be measured as diagnostic prognostic biomarkers, starting from early stages disease. While in animal models AD pathology, aggregates have been shown disrupt neuronal...
Given the large number of genes purported to be prognostic for breast cancer, it would optimal if identified are not confounded by continuously changing systemic therapies. The aim this study was discover and validate a cancer expression signature distant metastasis in untreated, early stage, lymph node-negative (N-) estrogen receptor-positive (ER+) patients with extensive follow-up times. 197 previously associated ER status were profiled from 142 untreated subjects. A "metastasis score"...
<b><i>Background:</i></b> Prostate cancer is a leading public health burden worldwide, and in New Zealand it the most commonly registered third cause of deaths among males. Genetic variability its associations with diet, demographic lifestyle factors could influence risk this disease. <b><i>Methods:</i></b> The single nucleotide polymorphisms (SNPs) within group antioxidant genes related markers were tested between patient control cohorts,...
Parenchymal mass preservation, and ischemia type and/or duration can influence functional recovery after partial nephrectomy. Some groups have hypothesized that relevant comorbidities may also impact nephron stability but this has not been adequately investigated.At our center 405 patients treated with nephrectomy from 2007 to 2015 had the necessary data determine function parenchymal preserved in ipsilateral kidney. Comorbidities potentially associated renal status were reviewed, including...
BackgroundUterine fibroids are one of the most common neoplasms found among women globally, with a prevalence approximately 11 million in United States alone. The morbidity this disease is significant because it leading cause hysterectomy and causes functional impairment for reproductive age. Factors including age, body mass index, race, ethnicity, menstrual blood loss, fibroid location, uterine volume influence incidence severity symptoms. Elagolix an oral gonadotropin-releasing hormone...
Abstract Clinical and animal studies have shown that coexpression of the receptor tyrosine kinases HER2 epidermal growth factor (EGF) (EGFR) indicates a highly metastatic phenotype breast cancer. In cellular model this using differential gene expression analysis, we identified TOB1 to be up-regulated depending on EGF stimulation transduction through phosphorylation 1248. mRNA analysis cancers from cohort node-negative patients showed significantly shortened distant metastasis-free survival...
Background: There is variable reporting on the benefits of a 200 μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis to understand whether stratified groups receive health. Methods: 572 men were supplemented with µg/d as selinized yeast for six months, and 481 completed protocol. Selenium prostate-specific antigen (PSA) levels measured in serum at pre- post-supplementation. Changes PSA subsequent assessed without demographic, lifestyle, genetic...
Abstract Background: Recent studies have demonstrated independent validation of the prognostic relevance residual cancer burden (RCB) after neoadjuvant chemotherapy. However, a pooled subject-level analysis multiple cohorts is needed to determine estimates long-term prognosis for each class RCB in phenotypic subtype breast (BC) better inform on patient outcomes. Also, allows more detailed analyses generalizability meaning assessments broader experience practice settings. Method:...
"HSR25-180: Real-World (rw) Characteristics, Treatment (tx) Patterns and Clinical Outcomes in Patients (pts) With Limited-Stage Small-Cell Lung Cancer (LS-SCLC) Who Received Chemoradiotherapy (CRT)" published on 28 Mar 2025 by National Comprehensive Network.
Immunotherapy has altered the treatment landscape for resectable non-small cell lung cancer, increasing complexity of planning. Understanding patterns and outcomes prior to advent immunotherapy can provide context assessing benefit immunotherapies other novel agents. We aimed characterize real-world demographics, clinical characteristics, patterns, patients with early-stage cancer before widespread use. Analyses included from US CancerLinQ Discovery® database diagnosed stage I-III between...
Outcome predictors in use today are prognostic only for hormone receptor-positive (HRpos) breast cancer. Although microarray-derived multigene of receptor-negative (HRneg) and/or triple negative (Tneg) cancer recurrence risk emerging, to date none have been transferred clinically suitable assay platforms (for example, RT-PCR) or validated against formalin-fixed paraffin-embedded (FFPE) HRneg/Tneg samples. Multiplexed RT-PCR was used two signatures IR-7 and Buck-4) a pooled FFPE collection...
The standard treatment for epithelial ovarian cancer (EOC) patients with advanced disease is carboplatin-paclitaxel combination therapy following initial debulking surgery, yet there wide inter-patient variation in clinical response. We sought to identify pharmacogenomic markers related therapy. lymphoblastoid cell lines, derived from 74 invasive EOC seen at the Mayo Clinic, were treated increasing concentrations of carboplatin and/or paclitaxel and assessed vitro drug response using MTT...
To determine if coexisting adenomyosis limits the efficacy of elagolix, an oral gonadotropin-releasing hormone antagonist, with hormonal add-back therapy in reducing heavy menstrual bleeding women uterine fibroids.Pooled analysis two identical, double-blind, randomized, placebo-controlled, 6-month phase 3 trials (Elaris Uterine Fibroids [UF]-1 and UF-2).A total 153 gynecological clinical care settings United States Canada.Premenopausal (18-51 years) >80 mL blood loss (MBL)/cycle fibroids...
Abstract It is being debated whether prostate-specific antigen (PSA)-based screening effectively reduces prostate cancer mortality. Some of the uncertainty could be related to deficiencies in age-based PSA cut-off thresholds used screening. Current study considered 2779 men with and 1606 without a diagnosis, recruited for various studies New Zealand, US, Taiwan. Association demographic, lifestyle, clinical characteristics (for cases), aldo–keto reductase 1C3 ( AKR1C3 ) rs12529 genetic...
Androgen deprivation therapy (ADT) is an effective palliation treatment in men with advanced prostate cancer (PC). However, ADT has well documented side effects that could alter the patient's health-related quality of life (HRQoL). The current study aims to test whether a genetic stratification provide better knowledge for optimising options minimize HRQoL effects. A cohort 206 PC survivors (75 treated and 131 without ADT) was recruited written consent collect patient characteristics,...
Reduction in bone mineral density (BMD) is a common side effect of androgen deprivation therapy (ADT). We aimed to examine the cross-sectional and longitudinal variation BMD associated markers patients with nonmetastatic prostate cancer (PCa) managed without ADT.Bone total body, lumbar spine, femoral neck, ultradistal forearm, one-third distal radius was measured 88 PCa metastases at baseline 6 months. Patients were categorized into 4 groups: (1) acute ADT (≤6 months), (2) chronic (>6 (3)...
Age is often considered an important non-modifiable risk factor for a number of diseases, including prostate cancer. Some prominent factors cancer include familial history, ethnicity and age. In this review, various genetic physiological characteristics affected due to advancing age will be analysed correlated with their direct effect on