A5064475828- Lung Cancer Treatments and Mutations
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Cancer Mechanisms and Therapy
- Chronic Myeloid Leukemia Treatments
- RNA Interference and Gene Delivery
Centralia College
2021
Providence College
2021
Oregon State University
2016
We report an efficient therapeutic modality for platinum resistant ovarian cancer based on siRNA-mediated suppression of a multifunctional DJ-1 protein that is responsible the proliferation, growth, invasion, oxidative stress, and overall survival various cancers. The developed strategy can work alone or in concert with low dose first line chemotherapeutic agent cisplatin, to elicit maximal response. To achieve knockdown, we constructed polypropylenimine dendrimer-based nanoplatform targeted...