A5088136446- Nanoparticle-Based Drug Delivery
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Signaling Pathways in Disease
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Peripheral Nerve Disorders
- Anesthesia and Pain Management
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Intraoperative Neuromonitoring and Anesthetic Effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Diamond and Carbon-based Materials Research
- Cancer Mechanisms and Therapy
- Supramolecular Self-Assembly in Materials
- Medical Imaging Techniques and Applications
- Retinoids in leukemia and cellular processes
- Advanced Drug Delivery Systems
- Vaccine Coverage and Hesitancy
- biodegradable polymer synthesis and properties
- Bioactive Compounds and Antitumor Agents
Oregon Health & Science University
2020-2024
Oregon State University
2016-2022
Portland State University
2019
Long Island University
2016
We report an efficient therapeutic modality for platinum resistant ovarian cancer based on siRNA-mediated suppression of a multifunctional DJ-1 protein that is responsible the proliferation, growth, invasion, oxidative stress, and overall survival various cancers. The developed strategy can work alone or in concert with low dose first line chemotherapeutic agent cisplatin, to elicit maximal response. To achieve knockdown, we constructed polypropylenimine dendrimer-based nanoplatform targeted...
Background & Aims: Pancreatitis is an inflammatory disease of the exocrine pancreas and a known risk factor for pancreatic ductal adenocarcinoma (PDAC). We previously identified HMG-box transcription 1 (HBP1) as potential master (TF) involved in early progression PDAC associated with poor patient survival. However, functional role HBP1 pathophysiological mechanism from acute to chronic pancreatitis remains unclear. Methods: examined expression human samples cerulein-induced mouse model....
Background and Aims: Chronic pancreatitis (CP) is characterized by inflammation, fibrosis, acinar-to-ductal metaplasia (ADM). PIN1, known to drive oncogenic signaling cellular plasticity in cancer, has an unexplored role CP. This study investigates PIN1's expression function CP pathogenesis using human tissues mouse models. Methods: PIN1 was assessed tissue microarrays (TMAs) via immunohistochemistry (IHC) cyclic immunofluorescence (CyCIF). Acute chronic were induced wild-type (WT) knockout...
Pancreatic ductal adenocarcinoma (PDAC) presents as an unmet clinical challenge for drug delivery due to its unique hypoxic biology. Vinblastine-N-Oxide (CPD100) is a hypoxia-activated prodrug (HAP) that selectively converts parent compound, vinblastine, potent cytotoxic agent, under oxygen gradient. The study evaluates the efficacy of microfluidics formulated liposomal CPD100 (CPD100Li) in PDAC. CPD100Li were with size 95 nm and polydispersity index 0.2. was stable period 18 months when...
Iatrogenic nerve injury significantly affects surgical outcomes. Although intraoperative neuromonitoring is utilized, identification remains challenging and the success of sparing strongly correlated with surgeon experience levels. Fluorescence guided surgery (FGS) offers a potential solution for improved by providing direct visualization tissue intraoperatively. However, novel probes FGS face long regulatory pathway to achieve clinical translation. Herein, we report on development...
Emerging treatment paradigms like targeting the tumor microenvironment and/or dosing as part of a metronomic regimen are anticipated to produce better outcomes in ovarian cancer, but current drug delivery systems lacking. We have designed and evaluated paclitaxel (PTX) rapamycin (RAP) micellar that can be tailored for various regimens target microenvironment. Individual mixed PTX/RAP (MIX-M) micelles prepared by conjugating drugs poly(ethylene glycol)-block-poly(β-benzyl l-aspartate) using...
Pancreatic cancer remains a formidable challenge due to limited treatment options and its aggressive nature. In recent years, the naturally occurring anticancer compound juglone has emerged as potential therapeutic candidate, showing promising results in inhibiting tumor growth inducing cell apoptosis. However, concerns over toxicity have hampered juglone’s clinical application. To address this issue, we explored use of polymeric micelles delivery system for pancreatic treatment. These...
Nerves are extremely difficult to identify and often accidently damaged during surgery, leaving patients with lasting pain numbness. Herein, a novel near-infrared (NIR) nerve-specific fluorophore, LGW01-08, was utilized for enhanced nerve identification using fluorescence guided surgery (FGS), formulated clinical translatable strategies. Formulated LGW01-08 examined toxicology, pharmacokinetics (PK), pharmacodynamics (PD) parameters in preparation future translation. Optimal imaging doses...
Metabolic reprogramming is a central feature in many cancer subtypes and hallmark of cancer. Many therapeutic strategies attempt to exploit this feature, often having unintended side effects on normal metabolic programs limited efficacy due integrative nature substrate sourcing. Although the initiating oncogenic lesion may vary, tumor cells lymphoid malignancies share similar environments potentially profiles. We examined from mouse models MYC-, RAS-, BCR-ABL-driven find convergence de novo...
Abstract One of the most aggressive cancers in US is pancreatic ductal adenocarcinoma (PDAc), whose incidence expected to rise coming years. The standard-of-care treatments have improved over past few decades, but they still primarily involve harsh chemotherapy cocktails and only marginally increased overall survival, a 5-year survival rate 12 percent. c-MYC (MYC), potent transcription factor, frequently dysregulated PDAc. In PDAc other cancers, MYC plays significant role tumor progression,...
Abstract Pancreatic cancer associated fibroblasts (CAFs) play multiple, often conflicting, roles to support or restrict tumor growth. Recent work suggests that heterogeneous differentiation states of contribute these diverse functions and reprogramming fibroblast can influence outcomes. How distinct subpopulations affect development growth, however, remains incompletely understood. PIN1 is a phosphorylation-directed prolyl isomerase alters the conformation and, therefore, function many...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC), a disease predominantly associated with chronic inflammation, ranks as the third-leading cause of cancer-related mortality. The limited efficacy current PDAC therapies is, in part, attributed to challenges posed by late- stage diagnosis, highlighting urgent need for early detection techniques improve treatment outcomes. Sustained pancreatic inflammation induces production reactive oxygen species, leading activation DNA damage...
Background: COVID-19, an infectious respiratory illness caused by SARS-Cov 2 spread across the world and declared as pandemic in 2019. With successive trail of COVID vaccine, attention was turned towards its distribution uptake. Vaccine hesitancy greatest threat to mass vaccination drive, which major barrier for achieving desired goal. The main objective is understand knowledge, attitude practices COVID-19 vaccine among staff urban health centres Gandhinagar municipal corporation. Methods: A...
Abstract The objective of this work is to evaluate the effect individual & combinatorial delivery Docetaxel (DTX) and Everolimus (EVR) in polymeric micelles at frequent dosing regimen below their maximum tolerated dose on angiogenesis, efficacy immune signaling breast cancer animal model. Based previous in-vivowork our lab, (MTDs) for EVR, DTX 50, 25 20 mg/kg respectively. To achieve goal, two studies have been conducted. First, in-vivo assessment anti-angiogenic effects dual DTX-EVR...
The prolyl isomerase PIN1 is overexpressed in cancer and contributes to cell-intrinsic phenotypes including proliferation migration. While its pro-tumor role has generated interest targeting PIN1, tumor-associated stromal not yet been studied. Here, we show that addition contributing intrinsic tumor cell phenotypes, a critical regulator of fibroblast differentiation states. Loss pancreatic stellate cells, the primary cells responsible for expansion tumors, impairs epigenetic response TGF β...