A5083508271- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Oropharyngeal Anatomy and Pathologies
- Heart Failure Treatment and Management
- Kawasaki Disease and Coronary Complications
- Intracranial Aneurysms: Treatment and Complications
- Thyroid Disorders and Treatments
- Frailty in Older Adults
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Coronary Interventions and Diagnostics
- Receptor Mechanisms and Signaling
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Glutathione Transferases and Polymorphisms
- Antioxidant Activity and Oxidative Stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Moyamoya disease diagnosis and treatment
- IgG4-Related and Inflammatory Diseases
- Vitamin C and Antioxidants Research
- Magnesium in Health and Disease
Gaziantep University
2019-2024
Gaziantep Children's Hospital
2016-2019
State Hospital
2019
Institute of Cardiology
2015
Ankara University
2011
Carcinogenic and toxic molecules produce DNA adducts that contribute to the development of atherosclerosis. Genetic polymorphisms xenobiotic-detoxified enzymes, which control level adducts, may affect both enzymatic activity individual susceptibility coronary artery disease (CAD). In this study we investigated effects genetic CYP1A1*2C, GSTT1, GSTM1 enzymes on CAD risk in a Turkish population. Genotypes were determined for 132 patients 151 healthy controls by polymerase chain...
Abstract Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and a major cause of morbidity mortality. The upregulation TRP channels believed to mediate progression electrical remodelling arrhythmogenesis diseased heart. However, there limited data about contribution development AF. aim this study was investigate leukocyte gene expressions non-valvular atrial (NVAF) patients. included 47 NVAF patients sex age matched controls. mRNA extracted from blood samples,...
Endothelial dysfunction (ED) is a condition that involves increased oxidative stress and decreased total antioxidant status (TAS) levels. Systemic lupus erythematosus (SLE) also associated with ED. We aimed to determine the association between serum TAS ED as assessed by flow-mediated dilation (FMD) in patients SLE.Thirty-four stable SLE who were not undergoing any treatment 39 healthy volunteers without overt cardiovascular disease included this cross-sectional study. Doppler ultrasound was...
The relationship between bilirubin levels and peripheral artery disease has been documented. Our aim was to demonstrate the possible serum abdominal aortic aneurysms (AAAs). study included 219 patients, 110 had a previous diagnosis of AAA 109 patients were normal controls. Only with AAAs which size 40 54 mm in study. Baseline laboratory values 2 computerized tomographic measurements 12 months apart recorded. Patients significantly higher white blood cell (WBC) counts neutrophil–lymphocyte...
It is unclear whether isolated coronary artery ectasia (iCAE) associated with whole blood viscosity (WBV). In the present study, we investigated WBV in (CAE) patients.Seventy-eight patients iCAE and 83 controls normal arteries were selected from 12290 who underwent angiography between January 2014 December 2017. was calculated a validated equation hematocrit total plasma protein levels for low (LSR) high (HSR) shear rate.Baseline demographic characteristics medical history of groups similar....
Sodium-glucose co-transporter-2 inhibitors (SGLT-2i) are a new class of drugs that lower blood glucose and reduce mortality in heart failure patients with reduced ejection fraction (HFrEF). They also have antioxidant effects. The exact mechanism SGLT-2i is unknown. This study investigated the effects on asprosin, matrix metalloproteinase (MMP), tissue inhibitor MMP (TIMP-1) concentrations echocardiographic measurements strain left chamber.
Graves' disease has a multitude of effects on the cardiovascular system. In detection subclinical left ventricular dysfunction, speckle-tracking echocardiography is more useful than conventional echocardiography. The aim present study was to compare longitudinal global strain values and venous blood concentration (tissue inhibitor metalloproteinase-1) TIMP-1, regulator extracellular matrix, among hyperthyroid patients with disease, euthyroid healthy control subjects.The enrolled 40 newly...
The aim of this study was to compare the simultaneous double-protection method (proximal balloon plus distal filter) with distal-filter protection or proximal-balloon alone in asymptomatic patients during carotid artery stenting.119 consecutive were investigated for stentings extracranial internal use filters (n = 41, 34.4 %), proximal (MoMa) 40, 33.6 %) double 38, 31.9 %). Magnetic resonance imaging (MRI) performed on all before procedure, and control diffusion-weighted MRI (DW-MRI)...
Lower extremity arterial disease (LEAD) is a well-established risk factor for concomitant coronary artery (CAD). There are no published data combining all three lower limb segments (aortoiliac, femoropopliteal and below the knee vessels) in order to estimate CAD severity LEAD patients. Herein has been derived new scoring system this purpose, which uses wellknown TASC II classification, Syntax score and, first time medical literature, score.The study population consisted of 178 patients who...
Background and Aims Few studies have shown the direct effect of familial hypercholesterolemia ( FH ) on myocardial systolic function. Studies focused heterozygote patients but not homozygote ones, they did perform genetic analyses. We aimed to evaluate all types with using potentially more sensitive speckle tracking echocardiography STE technique identify early left ventricular LV dysfunction. Methods Genetic analyses were conducted for LDL ‐receptor, PCSK 9, ApoB100. Nine homozygote, two...
The aim of the present study is to investigate cardioprotective effect lycopene, known for its antioxidant and anti-inflammatory effect, in a rat sepsis model induced by lypopolysaccharide (LPS).The oxidative stress parameters, parameters cytokine levels with or without lycopene treatment LPS‑induced septic rats as well controls were measured serum tissue. Histologic examinations cardiac tissues also performed. Kruskal-Wallis Bonferroni-adjusted Mann-Whitney U Test was used analysis. A p...
Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity has been associated with the risk of clinical cardiovascular events.In this study, we aimed to investigate whether Lp-PLA2 presents a for subclinical atherosclerosis in young patients premature ovarian failure (POF).Consecutive and biochemical evidence naïve POF (n = 66) January February 2018 age-matched healthy controls 73) were enrolled. activity, fibrinogen concentrations, high- sensitivity C-reactive protein (Hs-CRP) levels,...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Aim To investigate the relationship between malnutrition and follow-up cardiovascular (CV) events in non-ST-segment elevation myocardial infarction (NSTEMI). Material methods A retrospective study was performed on 298 patients with NSTEMI. The baseline geriatric nutritionalrisk index (GNRI) calculated at first visit. were divided into three groups accordingto GNRI: >98, no-risk; 92 to ≤98, low risk; 82 <92, moderate high (MTH) risk. studyendpoint a composite of CV events, including...
PURPOSE: The geriatric nutritional risk index (GNRI) is a simple and objective assessment tool for elderly patients.Lower GNRI values are associated with worse prognosis in heart failure reduced ejection fraction (HFrEF).Our aim to investigate the relationship between malnutrition follow-up cardiovascular (CV) events HFrEF.METHODS: A retrospective study was performed on 362 patients HFrEF.The baseline calculated at fi rst visit.The were divided into three groups according GNRI: >98, no-risk...
<title>Abstract</title> <bold>Background and Aim</bold>: Hashimoto's thyroiditis (HT), which is an autoimmune condition the primary cause of hypothyroidism, has numerous impacts on cardiovascular system. Speckle-tracking echocardiography (STE) enables earlier detection left ventricular (LV) dysfunction compared to conventional echocardiography. The tissue inhibitor metalloproteinase-1 (TIMP-1) a key molecule that plays role in cardiac remodeling various pathologies. objective this study was...
Background Cerebral infarction in patients with atrial fibrillation (AF) may clinically vary from being silent to catastrophic. Silent cerebral (SCI) is the neuronal injury absence of appearent stroke or transient ischaemic attack. Serum neuron specific enolase (NSE) suggested be a valid surrogate biomarker that allows detect recent injury. We aimed evaluate incidence SCI by positive NSE levels non-valvular AF (NVAF) on oral anticoagulants.Methods Blood samples for were collected 197...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
In this study, we measured the levels of Kelch-like ECH-associated protein 1 (KEAP1), which has potential antioxidant capacity, among non-ST elevation myocardial infarction (NSTEMI) patients compared with healthy controls. We also investigated possible association between KEAP1 and GRACE score, is a universal risk score commonly used for acute infarction.As patient group, 78 admitted to our center diagnosis NSTEMI were included in study. As control 77 individuals found have normal coronary...