A5073155596- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Spaceflight effects on biology
- Ion channel regulation and function
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac electrophysiology and arrhythmias
- Biochemical effects in animals
- High Altitude and Hypoxia
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Muscle metabolism and nutrition
- Pediatric Pain Management Techniques
- Pain Management and Opioid Use
- Spine and Intervertebral Disc Pathology
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Enhanced Recovery After Surgery
- Cardiac Arrhythmias and Treatments
- Bacterial Identification and Susceptibility Testing
University of Florida
2016-2025
Cognitive Research (United States)
2025
Florida College
2015-2024
University of Florida Health
2021
University of Utah Hospital
2019
Marymount University
2013
Gainesville Obstetrics & Gynecology
2002
Heidelberg University
1994
Background We tested the hypothesis that in newborn rats, sevoflurane may cause seizures, neurotoxicity, and impairment synaptic plasticity-effects be diminished by Na-K-2Cl cotransporter 1 inhibitor, bumetanide. Methods Electroencephalography, activated caspase-3, hippocampal long-term potentiation were measured rats exposed to 2.1% for 0.5-6 h at postnatal days 4-17 (P4-P17). Results Arterial blood gas samples drawn a concentration of showed no evidence either hypoxia or hypoventilation...
Visual loss is a rare, but catastrophic, complication of surgery in the prone position. The position increases intraocular pressure (IOP), which may lead to visual by decreasing perfusion anterior optic nerve. We tested whether reverse Trendelenburg ameliorates increase IOP caused positioning. Furthermore, we compared two positioning set ups. 10 healthy awake volunteers was measured at 3 different degrees inclination (horizontal, Trendelenburg, and Trendelenburg) sitting supine positions...
We hypothesized that custom-designed microemulsions would effectively scavenge compounds from bulk media. Pluronic-based oil-in-water were synthesized efficiently reduced the free concentration of local anesthetic bupivacaine in 0.9% NaCl. Both molecular nature and constituents significantly affected extraction efficiencies. Pluronic F127-based extracted more than using other surfactants (L44, L62, L64, F77, F87, F88, P104). Extraction was markedly increased by addition fatty acid sodium...
The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have susceptibility the side effects neonatal anesthesia sevoflurane.Postnatal day 4-20 (P4-P20) rats were exposed sevoflurane, 6% and 2.1%, for 3 min 60-360 min, respectively. Exogenous was administered imitate aldosterone.Six hours sevoflurane on P4-P5 resulted in a more than 30-fold increase serum (7.02 ± 1.61 ng/dl vs. 263.75 22.31 ng/dl,...
The authors studied whether neonatal propofol anesthesia affects development of the endocrine and neural systems.Sprague-Dawley rats were anesthetized using intraperitoneal for 5 h on postnatal days (P) 4, 5, or 6. Pups that received either saline intralipid, but not those in negative control groups, also maternally separated h. Serum levels corticosterone measured immediately after adulthood prepulse inhibition acoustic startle testing (≥P80), followed by measurement hippocampal neuronal...
The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, sevoflurane exhibit substantial differences their actions. authors sought to determine whether these can also be detected at the level of neurodevelopmental effects.Postnatal rats, 4-6 days old, were exposed 1.2% or 2.1% for 1-6 h studied immediate delayed effects.Isoflurane exposure was associated with...
Sevoflurane administered to neonatal rats induces neurobehavioral abnormalities and epigenetic reprogramming of their germ cells; the latter can pass adverse effects sevoflurane future offspring. As cells are susceptible by environmental factors across lifespan, authors hypothesized that adult could induce in offspring, but not exposed themselves.Sprague-Dawley were anesthetized with 2.1% for 3 h every other day between postnatal days 56 60. Twenty-five later, nonexposed controls mated...
Background: Vulnerability to perioperative neurocognitive disorder (PND) and the mechanisms initiating PND, which may serve as targets for prevention, are incompletely understood. We hypothesized that sevoflurane can induce persistent upregulation of hypothalamic-pituitary-adrenal (HPA) axis, inflammation, behavioral deficits in young adult male rats by stimulating hypothalamic arginine vasopressin (AVP) production via Na + -K -Cl - (NKCC1) Cl importer/GABA A receptor (GABA R) signaling....
Ceftobiprole is a promising new broad-spectrum cephalosporin with activity against several multidrug-resistant gram-positive and gram-negative species, including methicillin-resistant Staphylococcus aureus. In order to make efficacy predications these resistant bacteria in soft-tissue infections, i.e., skin structure ceftobiprole's ability reach the site of action should be explored. Therefore, microdialysis study was conducted 12 healthy volunteers determine penetration ceftobiprole into...
Cannabis use is increasing among older adults, but its impact on postoperative pain outcomes remains unclear in this population. We examined the association between cannabis and levels opioid doses within 24 hours of surgery.
Individuals with neurodegenerative disorders are often provided the same perioperative care as unaffected peers, even though unidentified diminished preoperative "brain health" worsens surgical outcomes. We summarize implementation and standardized data from a phased cognitive assessment consisting of screening tests administered by clinic staff and, on failed screening, an immediate neuropsychological licensed neuropsychologists. The present observational study used deidentified patient via...
The cellular mechanisms that underlie impaired brain function during phenylketonuria (PKU), the most common biochemical cause of mental retardation in humans, remain unclear. Acute application L-Phe at concentrations observed PKU depresses glutamatergic synaptic transmission but does not affect GABA receptor activity cultured neurons. If these depressant effects take place brain, then chronic impairment glutamate system, which may contribute to function, could be detected as changes...