A5048623750- Neuroscience of respiration and sleep
- Trauma and Emergency Care Studies
- Sinusitis and nasal conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Emergency and Acute Care Studies
- Head and Neck Surgical Oncology
- Cystic Fibrosis Research Advances
- Heart Rate Variability and Autonomic Control
- Traffic and Road Safety
- Optical Imaging and Spectroscopy Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infant Development and Preterm Care
- Injury Epidemiology and Prevention
- COVID-19 Clinical Research Studies
- Infant Health and Development
- Nosocomial Infections in ICU
- Cardiac Arrest and Resuscitation
- Acute Kidney Injury Research
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Nutrition and Health in Aging
- Nasal Surgery and Airway Studies
University of Oslo
2014-2025
Akershus University Hospital
2014-2025
Institute of Clinical Research
2022
Background: Growth differentiation factor 15 (GDF-15) is a strong prognostic marker in sepsis and cardiovascular disease (CVD). The value of GDF-15 coronavirus 2019 (COVID-19) unknown. Methods: Consecutive, hospitalized patients with laboratory-confirmed infection severe acute respiratory syndrome 2 (SARS-CoV-2) symptoms COVID-19 were enrolled the prospective, observational COVID Mechanisms Study. Biobank samples collected at baseline, day 3 9. primary end point was admission to intensive...
National Early Warning Score (NEWS) was designed to detect deteriorating patients in hospital wards, specifically those at increased risk of ICU admission, cardiac arrest, or death within 24 h. NEWS is not validated for use Emergency Departments (ED), but emerging data suggest it may be useful. A criticism that with chronic poor oxygenation, e.g. severe obstructive pulmonary disease (COPD), will have elevated also the absence acute deterioration, possibly reducing predictive power this...
To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, impact dexamethasone as standard therapy.This multicentre, observational, retrospective study included patients ≥ 18 years admitted from March 1st 2020 to January 31st 2021 with infection who received mechanical ventilation. Patient characteristics, clinical therapy survival were examined.155/156 (115 men, mean age 62 years, range 26-84 years) included. 67 (43%) had 90...
Background: The ability of an organism to withstand trauma is determined by the injury per se and inherent properties at time injury. We analyzed whether pre-injury morbidity scored on a four-level ordinal scale according American Society Anesthesiologists Physical Status (ASA-PS) classification system predicts mortality after trauma. Materials: From total 3,773 prospectively collected patients (years 2000–2004), 3,728 were included. Main outcome measure was 30 days effect ASA-PS assessed...
Introduction Anatomic injury, physiological derangement, age, and injury mechanism are well‐founded predictors of trauma outcome. We aimed to develop validate the first S candinavian survival prediction model for trauma. Methods Eligible were patients admitted O slo U niversity H ospital llevål within 24 h after with I njury everity core ≥ 10, proximal penetrating injuries or received by a team. The derivation dataset comprised 5363 ( A ugust 2000 J uly 2006); validation 2517 2006 2008)....
To describe variations of paranasal sinus development in patients with cystic fibrosis (CF) and non-CF examined for inflammatory sinonasal disease. We focused on anatomic variants that predispose to orbital cerebral penetration during functional endoscopic surgery (FESS), e.g. hypoplasia the maxillary low ethmoid roof.One hundred sixteen CF (3-54 years, median 18) 136 control (7-51 31) were coronal CT sinuses. grouped according number confirmed mutations: CF-2 (n=70), CF-1 (n=32), CF-0...
To describe variations of paranasal sinus development in patients with cystic fibrosis (CF) and non-CF examined for inflammatory sinonasal disease. We focused on anatomic variants that predispose to orbital cerebral penetration during functional endoscopic surgery (FESS), e.g. hypoplasia the maxillary low ethmoid roof.One hundred sixteen CF (3-54 years, median 18) 136 control (7-51 31) were coronal CT sinuses. grouped according number confirmed mutations: CF-2 (n=70), CF-1 (n=32), CF-0...
Spontaneous breathing has beneficial effects on the circulation, since negative intrathoracic pressure enhances venous return and increases cardiac stroke volume. We quantified contribution of respiratory pump to preserve volume during hypovolemia in awake, young, healthy subjects. Noninvasive volume, output, heart rate, mean arterial (Finometer) were recorded 31 volunteers (19 women), 19-30 yr old, normovolemia (approximating 450- 500-ml reduction central blood volume) induced by lower-body...
In patients with cystic fibrosis (CF) the prevalence of paranasal sinus affection approaches 100%. We hypothesized that hyperviscous mucus reducing mucociliary clearance in CF could give sinonasal inflammatory patterns different from those non-CF patients. wanted to compare extent and distribution disease these two groups patients.One-hundred-and-eight (3-54 years old) 79 controls (7-51 confirmed at coronal CT were compared. The was noted for each summed all sinuses. Inflammatory identified...
Few studies have evaluated pre-hospital documentation quality. We retrospectively assessed emergency medical service (EMS) of key logistic, physiologic, and mechanistic variables in motor vehicle accidents (MVAs). Records from police, Emergency Medical Communication Centers (EMCC), ground air ambulances were collected for 189 MVAs involving 392 patients. Documentation Glasgow Coma Scale (GCS), respiratory rate (RR), systolic blood pressure (SBP) was classified as exact values, RTS...
Introduction Anatomic injury, physiological derangement, age, injury mechanism and pre‐injury comorbidity are well‐founded predictors of trauma outcome. Statistical prediction models may have poorer discrimination, calibration accuracy when applied in new locations. We aimed to compare the TRISS, TARN NORMIT survival a Norwegian population. Methods Consecutive patients admitted Oslo University Hospital Ullevål within 24 h after with Injury Severity Score ≥ 10, proximal penetrating injuries,...
Background Trauma is a leading global cause of death, and predicting the burden trauma admissions vital for good planning care. Seasonality in has been found several studies. Seasonal fluctuations daylight hours, temperature weather affect social cultural practices but also individual neuroendocrine rhythms that may ultimately modify behaviour potentially predispose to trauma. The aim present study was explore what extent observed seasonality daily could be explained by changes variables...
Little is known about how implementation of pneumoperitoneum and head-up tilt position contributes to general anesthesia-induced decrease in cerebral blood flow humans. We investigated this question patients undergoing laparoscopic cholecystectomy, hypothesizing that cardiorespiratory changes during procedure would reduce perfusion.In a nonrandomized, observational study 16 (American Society Anesthesiologists physical status I or II) internal carotid artery velocity was measured by Doppler...
Intact cerebral blood flow (CBF) is essential for metabolism and function, whereas hypoperfusion in relation to hypovolemia hypocapnia can lead severe damage. This study was designed assess internal carotid artery (ICA-BF) during simulated noninvasive positive pressure ventilation (PPV) young healthy humans. Beat-by-beat velocity (ICA aorta) were measured by Doppler ultrasound normovolemia (lower body negative pressure), with or without PPV 15 awake subjects. Heart rate, plethysmographic...
To assess whether MR imaging can improve characterization of ethmomaxillary opacification diagnosed at CT in patients with cystic fibrosis (CF) order to select that may benefit from functional endoscopic sinus surgery (FESS).Sixty-two CF (26 females and 36 males) aged 4-50 years (median 20 years) disease underwent examination the paranasal sinuses (coronal T1 STIR sequences). FESS had been performed 28 prior this study. signal intensities were interpreted as mucosal thickening or infectious...
Mortality rates in COVID-19 patients need of mechanical ventilation are high, with wide variations between countries. Most studies were retrospective, and results may not be generalizable due to differences demographics, healthcare organization surge capacity. We present a cohort mechanically ventilated from resource-rich, publicly financed system.Prospective study tertiary hospital. Consecutive SARS-CoV-2 positive adult admitted the ICU for 10 March 2020 04 May included. Triage treatment...